Earlier quoted context omitted.
Who performs the measurements? What instruments are used to perform those measurements? If there's someone or something performing the measurements, then they depend on that someone or something to interpret them. You are right that measurements and models facilitate a better human understanding of nature/ourselves. However, it is important to keep in mind that these things are maps, not the terrain.
A measurement can be the interaction between two sufficiently decoupled subsystems. But I don't really understand why there needs to be some "interpreter." Nature could be some computer/system that is minimizing Action over all possible trajectories. Humans attempt to communicate an approximation to this truth by writing down nonlinear differential equations.
More than there needing to be, it's just all we have.
It's impossible for us to know what the universe without us is like. All of our knowledge has been gathered and interpreted by us.
Maybe there is a reality that doesn't depend on us, but how could we ever know that?
We cannot remove ourselves from our experiences, so how could we ever know what those experiences/reality would be like without us?
How could you ever know what truth is, if there is no you to know it (or approximate it)?