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Proteins That May Restore Damaged Sound-Detecting Cells in the Ear

hopkinsmedicine.org

11–20 of 98 posts

Re: Proteins That May Restore Damaged Sound-Detecting Cells in the Ear

#11
post #3

My wife has premature hearing loss of an unknown cause. Doctor kind of shrugged when asked what could be done about it. This was some 15 years ago. I'll push her to make an appointment with a doc again to see if something new has been discovered.

wait another 15 years, sorry: this is very early-stage work.

I'm not hoping that this specifically will remedy her problems. But general understanding of hearing loss might have advanced since her non-diagnosis.

Re: Proteins That May Restore Damaged Sound-Detecting Cells in the Ear

#12
post #3

My wife has premature hearing loss of an unknown cause. Doctor kind of shrugged when asked what could be done about it. This was some 15 years ago. I'll push her to make an appointment with a doc again to see if something new has been discovered.

My dad has severe hearing loss (hearing aids, etc.) but we made an interesting discovery: bone-conduction headphones bypass the portion of his ear that's damaged. When he first put them on he literally said: "That's better than I've heard anything sound in a decade".

YMMV but it might be something useful to try with your wife.

Re: Proteins That May Restore Damaged Sound-Detecting Cells in the Ear

#13

I was hoping to read that it might also help people like myself who suffer from tinnitus. Sadly, no. Still, if it can restore hearing to the deaf, this is a good thing.

Restoration of hair cells may have knock-on effects for tinnitus.

If tinnitus is a maladaptive neuroplasticity (your brain "needs" to hear something so if it can't because you're deaf at that frequency it'll invent things for you to hear instead) that makes sense to model as some stable limit cycle of a nonlinear system -- which is one of the leading hypotheses for tinnitus right now -- then it's not totally implausible that restoration of function would change your tinnitus percepts.

It's not clear that it'd help, but I'm pretty confident that if we can restore hair cell function, someone's going to try.

Re: Proteins That May Restore Damaged Sound-Detecting Cells in the Ear

#14
I have early hearing loss. If you haven't checked out hearing aids in the last few years, they've improved significantly, although they remain appallingly expensive.

Wired wrote up a short piece about my hearing aids at the bottom of https://www.wired.com/story/why-we-love-tech-better-humans/

Of course, some drops to regain perfect hearing would be far better.

Re: Proteins That May Restore Damaged Sound-Detecting Cells in the Ear

#15

I was hoping to read that it might also help people like myself who suffer from tinnitus. Sadly, no. Still, if it can restore hearing to the deaf, this is a good thing.

Restoration of hair cells may have knock-on effects for tinnitus. If tinnitus is a maladaptive neuroplasticity (your brain "needs" to hear something so if it can't because you're deaf at that frequency it'll invent things for you to hear instead) that makes sense to model as some stable limit cycle of a nonlinear system -- which is one of the leading hypotheses for tinnitus right now -- then it's not totally implausi…

Yes -- although there are lots of folks with hearing loss who don't have tinnitus. There must be more to the story than just the ghost ringing that you're talking about. But I do think that the hypothesis you quote makes intuitive sense, at least as much as these hypercomplex things can be intuitive.

Re: Proteins That May Restore Damaged Sound-Detecting Cells in the Ear

#16

I was hoping to read that it might also help people like myself who suffer from tinnitus. Sadly, no. Still, if it can restore hearing to the deaf, this is a good thing.

Both of the prior posters are correct from my reading. You should also note that the comorbidity between sensorineural hearing loss and tinnitus is very high, again strongly suggesting that a subgroup will receive significant benefit if the hearing loss is fixed. In my experience, I would also recommend you seek out an ENT or audiologist that will do high frequency hearing testing (8 KHz to 16 KHz or higher). This is not standard in hearing tests, which max out at 8KHz because that is the functional range of speech and most sounds that affect daily life for humans, but loss of frequencies above that can often be present with tinnitus.

Re: Proteins That May Restore Damaged Sound-Detecting Cells in the Ear

#17
post #3

My wife has premature hearing loss of an unknown cause. Doctor kind of shrugged when asked what could be done about it. This was some 15 years ago. I'll push her to make an appointment with a doc again to see if something new has been discovered.

My dad has severe hearing loss (hearing aids, etc.) but we made an interesting discovery: bone-conduction headphones bypass the portion of his ear that's damaged. When he first put them on he literally said: "That's better than I've heard anything sound in a decade". YMMV but it might be something useful to try with your wife.

That's weird. I wonder what the physical reason could be, if (e.g.) it's the eardrum that's acting up on top of the damaged cochlea. (Could there be wax buildup?)

Re: Proteins That May Restore Damaged Sound-Detecting Cells in the Ear

#18
post #3

My wife has premature hearing loss of an unknown cause. Doctor kind of shrugged when asked what could be done about it. This was some 15 years ago. I'll push her to make an appointment with a doc again to see if something new has been discovered.

My dad has severe hearing loss (hearing aids, etc.) but we made an interesting discovery: bone-conduction headphones bypass the portion of his ear that's damaged. When he first put them on he literally said: "That's better than I've heard anything sound in a decade". YMMV but it might be something useful to try with your wife.

For what it's worth, this only works if the source of hearing loss is conductive (e.g. eardrum or the ossicles). If your cochlea or any sub-element (e.g. inner hair cells) are damaged, bone conduction will be no different. In fact, the comparison between acoustic and bone-conduction hearing tests is a key element of audiological testing.

Re: Proteins That May Restore Damaged Sound-Detecting Cells in the Ear

#19

I'm curious if this will enable not only the recovery of those cells but also allow us to extend our hearing range

Well, functionally speaking your range is set by the cells that you have that are alive, which die slowly over time, starting with the higher frequency ones which tend to be more fragile. If you could restore all the cells you had when you were a child you'd have a larger range than you have now. But you couldn't extend the range beyond what you had when you were born AFAIK.

Re: Proteins That May Restore Damaged Sound-Detecting Cells in the Ear

#20

Earlier quoted context omitted.

My dad has severe hearing loss (hearing aids, etc.) but we made an interesting discovery: bone-conduction headphones bypass the portion of his ear that's damaged. When he first put them on he literally said: "That's better than I've heard anything sound in a decade". YMMV but it might be something useful to try with your wife.

For what it's worth, this only works if the source of hearing loss is conductive (e.g. eardrum or the ossicles). If your cochlea or any sub-element (e.g. inner hair cells) are damaged, bone conduction will be no different. In fact, the comparison between acoustic and bone-conduction hearing tests is a key element of audiological testing.

True. The classic tuning fork test: hit the fork, hold it up in front of your ear. Can you hear it? Then gently press the end of the (still vibrating) fork against your skull. Can you hear it now? If no/yes, the loss is conductive. If no/no, it's sensorineural.
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