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Proteins That May Restore Damaged Sound-Detecting Cells in the Ear

hopkinsmedicine.org

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Re: Proteins That May Restore Damaged Sound-Detecting Cells in the Ear

#5
post #3

My wife has premature hearing loss of an unknown cause. Doctor kind of shrugged when asked what could be done about it. This was some 15 years ago. I'll push her to make an appointment with a doc again to see if something new has been discovered.

wait another 15 years, sorry: this is very early-stage work.

Re: Proteins That May Restore Damaged Sound-Detecting Cells in the Ear

#6
post #3

My wife has premature hearing loss of an unknown cause. Doctor kind of shrugged when asked what could be done about it. This was some 15 years ago. I'll push her to make an appointment with a doc again to see if something new has been discovered.

I try to keep up to date on this sort of thing as it affects me as well.

There are a few companies that are doing clinical trials in humans using drugs that may restore hearing. They've done a good job of keeping the results under lock and key so far but one of them (Frequency Therapeutics) might announcing some preliminary results next month. I've linked a press release from a few months ago.[1] As there are several companies attacking this problem from different angles, and an explosion in clinical trials, you wouldn't be crazy to be optimistic. If by luck any one of these drugs turns out to improve hearing by 10db or so, you might see the it on the market in no more than a few years.

[1] https://www.frequencytx.com/news-events/news-events-press-re...

Re: Proteins That May Restore Damaged Sound-Detecting Cells in the Ear

#7

I'm curious if this will enable not only the recovery of those cells but also allow us to extend our hearing range

it cannot. The frequency limits of hearing are set by the length (and material properties) of the basilar membrane, not the density of innervation.

Re: Proteins That May Restore Damaged Sound-Detecting Cells in the Ear

#8
post #6
post #3

My wife has premature hearing loss of an unknown cause. Doctor kind of shrugged when asked what could be done about it. This was some 15 years ago. I'll push her to make an appointment with a doc again to see if something new has been discovered.

I try to keep up to date on this sort of thing as it affects me as well. There are a few companies that are doing clinical trials in humans using drugs that may restore hearing. They've done a good job of keeping the results under lock and key so far but one of them (Frequency Therapeutics) might announcing some preliminary results next month. I've linked a press release from a few months ago.[1] As there are several…

decibel therapeutics https://decibeltx.com is also interesting.

Re: Proteins That May Restore Damaged Sound-Detecting Cells in the Ear

#9
post #3

My wife has premature hearing loss of an unknown cause. Doctor kind of shrugged when asked what could be done about it. This was some 15 years ago. I'll push her to make an appointment with a doc again to see if something new has been discovered.

[flagged]

Re: Proteins That May Restore Damaged Sound-Detecting Cells in the Ear

#10

I was hoping to read that it might also help people like myself who suffer from tinnitus. Sadly, no. Still, if it can restore hearing to the deaf, this is a good thing.

Even though it wasn't mentioned in the article, a lot of researchers in this field believe that a cure for hearing loss will take care of tinnitus and hyperacusis too, at least for a patient subgroup. There's tinnitus caused by muscle tension/dysfunction (?) which is of an entirely different etiology apparently, but the good news is that that kind seems more treatable than the kind caused by permanent hearing dysfunction.
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