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Ebola Is Now Curable

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Re: Ebola Is Now Curable

#81

Post by benj111 »

baxtr wrote: post #26
DoreenMichele wrote: post #22

Earlier quoted context omitted.

Just as a point of comparison: Toxic epidermal necrolysis, a severe form of Stevens-Johnson Syndrome, has about a 30% mortality rate. I understand it to be a first world problem typically caused by taking certain strong medications. It's a severe and often deadly allergic reaction. (I'm not going to provide links because both Wikipedia entries have disturbing photos. I've verified that I'm spelling both correctly so…

Puh. The photos are really disturbing. I really recommend anyone not to do what I just did...

I was about to reply and say they weren't too bad, 2 of them really not, 2 of them a couple of stages on from really bad sunburn. I was picturing that scene from Raiders of the lost Ark before hand, it's not that bad.

Re: Ebola Is Now Curable

#82

Post by Dylan16807 »

tomrod wrote: post #38
contravariant wrote: post #36

Earlier quoted context omitted.

We really need some kind of image-less Wikipedia for things like this.

elinks browser for the win! I bet images can be blocked by extension as well.

You're solving entirely the wrong problem. The issue is linking to the article, not "how do I personally view a page a certain way?"

Re: Ebola Is Now Curable

#83

Post by Dylan16807 »

Medicalidiot wrote: post #47
pvaldes wrote: post #40

Earlier quoted context omitted.

> I want to know how long it will take for Ebola to evolve a resistance to this therapy. Maybe never. A lot of time in any case, probably. Ebola is a plant's virus adapted to trees. Evolved to use bats (and probably arboreal snakes also) but can't survive for a long time in primates, and can't survive in soil at long term. We are a dead end for it. Would need infected humans munching some inedible leaves of a tropica…

In practical terms, there will be a resistance that develops eventually. Even though the reservoir is hypothesized to be bats, that doesn't have much significance because of its ability spread from person to person without a vector. What is notable about Ebola is that its virulence keeps dropping while its ability to spread has significantly increased. The larger issue is that Ebola is in areas that don't have the re…

For a resistance to develop, ebola that has been exposed to the treatment inside a hospital has to escape back into the wild. There are significant barriers in the way of that.

If everyone on penicillin was kept in an isolation chamber, the effectiveness over time would be different.

Re: Ebola Is Now Curable

#84

Post by jquery »

DoreenMichele wrote: post #22
throwaway5752 wrote: post #5

It's great news, but they're observing a 30% mortality rate for the "cure". Absent medical intervention there is still a nontrivial survival rate (mortality rate of 75-90%). With supporting medical treatment before this new treatment - fluid support, etc - I think it's up to 50%? It sounds like the monoclonal antibody treatment has improved odds of survival from 1:10-1:2 to 2:3. edit: The 6% figure is population rest…

Just as a point of comparison: Toxic epidermal necrolysis, a severe form of Stevens-Johnson Syndrome, has about a 30% mortality rate. I understand it to be a first world problem typically caused by taking certain strong medications. It's a severe and often deadly allergic reaction. (I'm not going to provide links because both Wikipedia entries have disturbing photos. I've verified that I'm spelling both correctly so…

"Not pretty" is an understatement.

Toxic epidermal necrolysis (TEN) is the most lethal on a scale of 4 related necrotic skin conditions[1]: TEN, SJS, EMMajor, EMMinor. The medical industry sees all 4 as kind of a sliding scale, similar to how burns are classified as different degrees and can be clinically distinguished but are still burns. They are categorized based on the percentage of your skin that becomes necrotic, and additionally which tissue types are affected.

My understanding is that herpes is one of the most common causes, although maybe that's only true for EMM and not TEN/SJS. For some reason, as we age, sometimes our body changes its reaction to herpes or other infections, becoming hypersensitive, resulting in one of the 4 previously mentioned necrotic skin conditions.

I'm sharing this, because even though my symptoms were literally staring the doctors in the face, it took years before a studious dermatologist figured out I had recurrent EMMajor. If you have "cankers" or "rashes" associated with your herpes outbreaks, ask your doctor about it, even if the rashes aren't painful. Recurrent EMMajor can be life-threatening without treatment[2] and can progress with further attacks.

[1]https://www.ncbi.nlm.nih.gov/pubmed/21873140

[2]https://www.nhs.uk/conditions/erythema-multiforme/ (warning: disturbing pictures)

Re: Ebola Is Now Curable

#85

Post by jquery »

lonelappde wrote: post #30
xkcd-sucks wrote: post #28

Earlier quoted context omitted.

Unpacking the name totally is even more brutal! "necro" -- "death" "lysis" -- "busting open" "epidermal" -- "skin" "syndrome" -- "no known cause" However, it's a little unclear why TEN is a point of comparison to Ebola, as one is a transmissible disease and one is something that happens to unlucky people typically in response to common small-molecule drugs. I guess TEN sounds like a probable side effect of antiviral…

The comparison is to show that even in technologically advanced societies, there are diseases with 30% survival rates.

A doctor once told me that so much of our higher survival rate is based on a few key drugs and supportive care to keep us alive while the body heals itself. We seem to possess remarkably few cures for the majority of diseases out there, we are mostly able to treat symptoms to buy time for our bodies to self-repair.

Re: Ebola Is Now Curable

#86

Post by jquery »

benj111 wrote: post #81
baxtr wrote: post #26

Earlier quoted context omitted.

Puh. The photos are really disturbing. I really recommend anyone not to do what I just did...

I was about to reply and say they weren't too bad, 2 of them really not, 2 of them a couple of stages on from really bad sunburn. I was picturing that scene from Raiders of the lost Ark before hand, it's not that bad.

Raiders of the Lost Ark is more accurate in real life, unfortunately. I don't know why they show such sanitized versions of the diseases (for SJS they show a photo of someone with Erythema Multiforme Major). The photo for TEN is almost certainly after a great deal of "clean up".

Re: Ebola Is Now Curable

#87

Post by friendly_chap »

benj111 wrote: post #79
WhitneyLand wrote: post #73

Earlier quoted context omitted.

>> the sort of hair-brained schemes HN believes would fool them Is there much value in an ad-hominem reply? Or in generalizing it to an entire community? The irony seems hard to avoid when such a generalization is made without mentioning any statistical foundation, while pontificating about statistics.

Have you read any thread that involves statistics? I havent really detected that low an opinion for the FDA in particular but I recognised the broad outline painted. I could add quite a few more generalisations myself while I'm at it, HN isn't solely populated by hyper intelligent, well reasoned, logical doctors, who form their ideas completely independently of everyone else. There's going to be group think, there's…

> sic although actually...

Not sure if that was for comedic effect but I laughed out loud! A brilliant demonstration of the behaviour you describe.

Re: Ebola Is Now Curable

#88

Post by aembleton »

MaxBarraclough wrote: post #14

Much-needed Outline.com of the article: https://outline.com/MJaPqX Wired.com is almost literally unreadable. It's a caricature of all that's wrong with modern web design. Is everyone else seeing what I'm seeing? http://u.cubeupload.com/temp9871/wired.png

Turn off javascript for wired.com and it works well. I use uMatrix to do it.

https://imgur.com/dg4MpiY

Re: Ebola Is Now Curable

#89

Post by aembleton »

OnlineCourage wrote: post #51

WHO: two of the four drugs we thought would work did not work as well as expected. WIRED: EBOLA CURED https://www.niaid.nih.gov/news-events/independent-monitoring...

Off topic, but does this meme/way of writing have a name?

It's used a lot in Youtube comments and it weirdly grates me.

Re: Ebola Is Now Curable

#90

Post by Aissen »

aembleton wrote: post #88
MaxBarraclough wrote: post #14

Much-needed Outline.com of the article: https://outline.com/MJaPqX Wired.com is almost literally unreadable. It's a caricature of all that's wrong with modern web design. Is everyone else seeing what I'm seeing? http://u.cubeupload.com/temp9871/wired.png

Turn off javascript for wired.com and it works well. I use uMatrix to do it. https://imgur.com/dg4MpiY

I use uBlock Origin to do it. It took me years to find it was the small button in the bottom right corner. Don't forget to save the settings for this website afterwards.
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