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Alarming surge in drug-resistant HIV uncovered

nature.com

101–110 of 237 posts

Re: Alarming surge in drug-resistant HIV uncovered

#101
post #75
post #11

I had a scare and took PeP this year. I had to ER shop. First one denied me coverage and made assumptions. I ended up getting care at a cost of ~$6000 to my insurance. I paid $270. I have great healthcare but this is obscene. I don’t want to get sick and die. I was being careful but accidents happen.

Are you sure it actually cost your insurance $6k? Usually they have a high rack rate and negotiate down.

PrEP was pretty expensive. It cost the NHS about £5000 per year in 2017.

Re: Alarming surge in drug-resistant HIV uncovered

#102
post #92
post #87

Earlier quoted context omitted.

With the advent of air travel most of these geographically distant places are less than 24 hours away.

... That can still make them distant? Is Australia less 'distant' from Europe now that it takes 24 hours instead of 6 weeks to get there? In some senses, yes, but not in the sense that the GP used 'distant' (i.e., as a objective word for 'not adjacent').

[deleted]

Re: Alarming surge in drug-resistant HIV uncovered

#103
post #92
post #87

Earlier quoted context omitted.

With the advent of air travel most of these geographically distant places are less than 24 hours away.

... That can still make them distant? Is Australia less 'distant' from Europe now that it takes 24 hours instead of 6 weeks to get there? In some senses, yes, but not in the sense that the GP used 'distant' (i.e., as a objective word for 'not adjacent').

[deleted]

Re: Alarming surge in drug-resistant HIV uncovered

#104
post #2

Well, PrEP is a miracle drug that has gone criminally underutilized in the fight to eradicate HIV. It would be nice to see governments really push it hard for a change.

Unless PrEP succeeds in eradicating HIV (which might be possible if enough people are on it to limit the spread of the virus), it seems tailor-made to breed resistance. We don't generally give antibiotics prophylactically. Using anti-retrovirals this way seems like a bad idea from a drug resistance perspective.

Re: Alarming surge in drug-resistant HIV uncovered

#105
post #101
post #75

Earlier quoted context omitted.

Are you sure it actually cost your insurance $6k? Usually they have a high rack rate and negotiate down.

PrEP was pretty expensive. It cost the NHS about £5000 per year in 2017.

I assume you meant per person?

Re: Alarming surge in drug-resistant HIV uncovered

#106
post #79

Earlier quoted context omitted.

What purpose does the phrase "geographically distant" serve here? Seriously, why include that? Because, for one thing, while this site was started by an american, in america, its absolutely read all over the world, and two, HIV rates are highest in these "geographically distant third world countries". This is a really strange thing to post.

It meant (to me) that there are several 'pockets' of this happening simultaneously, it's not some local 'strain' or 'outbreak'. I thought it was a crucial thing to add, for nuance. Not sure why you're so agitated over this.

I think it's because the poster understood it as saying they were geographically distant "from us", rather than that they are geographically distant from each other.

Re: Alarming surge in drug-resistant HIV uncovered

#107
post #14
post #2

Well, PrEP is a miracle drug that has gone criminally underutilized in the fight to eradicate HIV. It would be nice to see governments really push it hard for a change.

PrEP is hard to get, my doctor outright refused to prescribe it to me, they said they were not comfortable doing so

Get a second opinion.

Re: Alarming surge in drug-resistant HIV uncovered

#108
post #2

Well, PrEP is a miracle drug that has gone criminally underutilized in the fight to eradicate HIV. It would be nice to see governments really push it hard for a change.

Unless PrEP succeeds in eradicating HIV (which might be possible if enough people are on it to limit the spread of the virus), it seems tailor-made to breed resistance. We don't generally give antibiotics prophylactically. Using anti-retrovirals this way seems like a bad idea from a drug resistance perspective.

I wonder if that's true though. I don't have a medicine background but I'm loosely following this development. I think the term drug resistance became popular with all these tuberculosis cases. What happened was that people got TB, they went to the doctor and got medicine. Then things got better and people felt healthy again so they stopped taking their medicine. BUT in reality they were supposed to take it for a longer period of time and then TB broke out again. And thus becoming drug resistant.

https://www.who.int/tb/areas-of-work/drug-resistant-tb/xdr-t...

Re: Alarming surge in drug-resistant HIV uncovered

#109
post #101

Earlier quoted context omitted.

PrEP was pretty expensive. It cost the NHS about £5000 per year in 2017.

I assume you meant per person?

No per year per person. The NHS prescribes it long term for various high risk groups.

$6000 for a 'one off' course of treatment sounds very expensive.

Re: Alarming surge in drug-resistant HIV uncovered

#110
post #101

Earlier quoted context omitted.

PrEP was pretty expensive. It cost the NHS about £5000 per year in 2017.

I assume you meant per person?

Sorry, yes, per year per person. I got that from here: https://www.tht.org.uk/sites/default/files/2018-02/Briefing%...

> It has been estimated that the average lifetime cost to the NHS for a person living with HIV is £360,000. Around two thirds (68%) of these costs were for anti-HIV drugs. The cost of a year’s HIV treatment is about £11,000 and of PrEP £5,000. The NHS obtains Truvada at a cost of £3,000–£4000 per person per year. People need to take HIV treatment for the rest of their lives but PrEP will generally be needed for a much shorter period. It is believed that the patent for one of the key drugs in Truvada, Tenofovir, expires in 2017, slashing the cost of the drug from this time. There has been a collective call on Gilead, from those involved in PrEP activism, to lower the price of Truvada for use in PrEP, as there are concerns that PrEP may not be deemed to be affordable.

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