* Our German Short Hair Pointer had seizures which in time led to him having to be put down; despite having him treated at the Animal Medical Center in NYC amongst other places.
* Our English Cocker Spaniel (a found dog that was living on the street) had terrible dermatitis which caused him to lose much fur and I'm pretty sure was no fun him.
* Our Yorkshire Terrier had kidney disease, also with seizures, though much less common than the Pointer's until later in his life; he too eventually had to be put down due to kidney disease.
That was it for the pure breeds, I told my partner next dog get a mutt. Indeed she did, and he seems like a good dog so far--smart and happy.