Earlier quoted context omitted.
That's a terrible solution. I chose my monitor specifically because it's HIDPI, not high resolution. It's easier on my eyes to read smoothly rendered text in HIDPI than jaggedly rendered text all day long. Changing the resolution subverts that.
If you're using macOS, have you tried changing the screen resolution? On HiDPI monitors it doesn't produce "jaggedly rendered text" at all (in fact, Apple ships a number of laptops with this as the default configuration…)
It's an accessibility problem, not a resolution problem. Electron apps don't have this issue because you can resize each app individually to match your needs/screen settings. You can't do this with most native apps.