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Cannabidiol in Anxiety and Sleep: A Large Case Series

ncbi.nlm.nih.gov

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Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#131

Post by thedaemon »

leshow wrote: post #128
OldSchoolJohnny wrote: post #125

Earlier quoted context omitted.

Point number 2 is utterly untrue as any experienced cannabis enthusiast could tell you. Even if people don't know the strain or what the effects are it's pretty reliable that it will either energize them or send them to sleep.

It's not untrue, there is no definition genetically of what a pure sativa/indica strain even is, see my other comment here.

What they were saying is anyone with experience in cannabis can tell you after a few minute of smoking if it's sativa or indica. Doesn't matter if there is no genetic definition, there are obvious differences.

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#132

Post by pizza »

superkuh wrote: post #123

The dosages of CBD used in this study are far, far, too low to have any effect. Just like most CBD dosing in commercial situations. Usually scientific investigation use the actual useful dosages of 300-600 mg in humans. I guess these guys didn't do the required background review beforehand. CBD is not active at the CB1 or CB2 receptors. It has very low affinity for them. It has moderate affinity for the serotonin-1a…

Yeah, the cheapest CBD I could find on Google was ~$30/g (pre- tax, shipping, etc). Good luck convincing people to spend $600/mo on their sleep!

(I can already hear the HNers coming out of the woodwork to attest to their willingness to do so, how sleep is 1/3rd of your life and so if you're spending but the vast majority of people can't do that)

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#133

Post by cneurotic »

pizza wrote: post #132
superkuh wrote: post #123

The dosages of CBD used in this study are far, far, too low to have any effect. Just like most CBD dosing in commercial situations. Usually scientific investigation use the actual useful dosages of 300-600 mg in humans. I guess these guys didn't do the required background review beforehand. CBD is not active at the CB1 or CB2 receptors. It has very low affinity for them. It has moderate affinity for the serotonin-1a…

Yeah, the cheapest CBD I could find on Google was ~$30/g (pre- tax, shipping, etc). Good luck convincing people to spend $600/mo on their sleep! (I can already hear the HNers coming out of the woodwork to attest to their willingness to do so, how sleep is 1/3rd of your life and so if you're spending but the vast majority of people can't do that)

Ha, your parenthetical definitely anticipated me.

If I could RELIABLY score a solid 8 hours every single night, I would call $600/mo steep — but worth it.

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#134

Post by bob_theslob646 »

pizza wrote: post #132
superkuh wrote: post #123

The dosages of CBD used in this study are far, far, too low to have any effect. Just like most CBD dosing in commercial situations. Usually scientific investigation use the actual useful dosages of 300-600 mg in humans. I guess these guys didn't do the required background review beforehand. CBD is not active at the CB1 or CB2 receptors. It has very low affinity for them. It has moderate affinity for the serotonin-1a…

Yeah, the cheapest CBD I could find on Google was ~$30/g (pre- tax, shipping, etc). Good luck convincing people to spend $600/mo on their sleep! (I can already hear the HNers coming out of the woodwork to attest to their willingness to do so, how sleep is 1/3rd of your life and so if you're spending but the vast majority of people can't do that)

I bet you people would use it if it was their last resort to getting a good rest.

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#135

Post by pizza »

bob_theslob646 wrote: post #134
pizza wrote: post #132

Earlier quoted context omitted.

Yeah, the cheapest CBD I could find on Google was ~$30/g (pre- tax, shipping, etc). Good luck convincing people to spend $600/mo on their sleep! (I can already hear the HNers coming out of the woodwork to attest to their willingness to do so, how sleep is 1/3rd of your life and so if you're spending but the vast majority of people can't do that)

I bet you people would use it if it was their last resort to getting a good rest.

No doubt. Insomnia is merciless. It's just that, for a lot of people, this approach will be out of their reach. Not that that means we shouldn't try to make it affordable, of course.

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#136

Post by thedaemon »

leshow wrote: post #129
sharadov wrote: post #77

Earlier quoted context omitted.

Depends on whether you are smoking a sativa or indica, and what kind of activity you are involved in? Are you smoking alone or in a group setting. If you are smoking alone and have an anxious personality, I would rather smoke a Sativa strain with a higher CBD to THC ratio. Indicas sometimes take me to an anxious place, but it depends on my mental state before taking the drug. So much of it is setting ( great music, g…

> Depends on whether you are smoking a sativa or indica People really need to stop repeating this. There are pure cbd sativas just as there are pure cbd indicas. There is no definition for what a sativa/indica is besides what the leaves look like. There's no bearing on subjective high and strains. What people are experiencing is differing THC/CBD ratios.

You need to stop incorrectly correcting people. CBD is neither sativa or indica. Which strain CBD comes from doesn't change how it effects you.

All of the indica and sativa flower that I purchase is 0% CBD, yet I can most definitely tell the difference. It has nothing to do with the amount of CBD in it.

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#137

Post by intricatedetail »

kdmccormick wrote: post #111
awelkie wrote: post #109

Earlier quoted context omitted.

I think that's what the poster is saying. I believe "Cannabis causes schizophrenia!" should be in quotes.

Yes, but the replier is saying that THC, the primary active compound in Cannabis, can in fact worsen some of the symptoms of schizophrenia. As someone with Type I Bipolar, which has many similarities to schizophrenia, I agree that this is often the case.

That's why it should be legal so people who need it won't have to fiddle with the dealers. Obviously big pharma pays a lot so that won't happen.

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#138

Post by turingbike »

leshow wrote: post #127
clarityPhone wrote: post #84

Earlier quoted context omitted.

I get anxiety when I smoke and am way too young to attribute it to any sort of “reeder madness” - so it’s definitely a thing. I don’t smoke super often, and don’t always get anxiety when I do, but it definitely gave me terrible anxiety when I was younger. If anyone else gets anxiety when they smoke, I recommend smoking sativa instead of indica (nicknamed “in da couch” because of its anxiety effects). I was given the…

I hear this repeated a lot in different variations, some people say the exact opposite, but it's untrue. There's no real definition of what a '100% sativa' or '100% indica' even is. All we have to go by are characteristic leaf patterns between indica/sativa. In short, the whole 'indica body buzz' thing is unfounded. In fact, I remember hearing the EXACT opposite of what you heard a few years ago. I was told that sati…

This is a good first-order approximation, but there are other cannabinoids which influence the effects: CBN, THCV, and others [0]. Additionally, based on first-hand anecdata, I think there is good reason to believe that the terpene profile can have a big effect on the experience, as well as the flavor [1].

But, yeah, if THC causes anxiety for you, try to never go above a 1:1 THC:CBD ratio. For comparison, most sativas are around 200:1 (20% THC : .1% CBD). Since CBD is legal over the counter, you can usually enforce this ratio, regardless of the THC source.

[0] https://www.leafly.com/news/cannabis-101/list-major-cannabin... [1] https://www.leafly.com/news/cannabis-101/terpenes-the-flavor...

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#139

Post by grahamburger »

OldSchoolJohnny wrote: post #126
_carl_jung wrote: post #105

Earlier quoted context omitted.

I think they have this the wrong way round. Indica is known for its relaxation effects. Couch lock isn't due to anxiety but relaxed passivity, and sativa strains tend to promote overthinking and paranoia in those (inc. myself) prone to it.

No. It depends on the person entirely and if you start digging you will find about equal distribution of people who are calmed by a sativa and people who are calmed by an indica. I personally suspect that people who feel calm from a sativa are a little ADHD and it seems to make them think better and more calmly and indicas make them much more anxious because it exacerbates and existing condition.

This kind of matches my experience - the anxiety I get is from feeling like my mind is slowing down / not totally working properly and not knowing if it will ever come back. I think I am a bit ADHD, and caffeine has a kind of calming effect on me as well, so might be worth trying a sativa blend.

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#140

Post by jaequery »

JibJabDab wrote: post #119
jaequery wrote: post #41

Earlier quoted context omitted.

I’ve had chronic insomnia for over 3 years. The day I started CBD, was about 4 months ago. Right before that, my option was to try Ambien that I had to pry off from the doctors hands. I’ve not had the guts to try it after hearing it messes with your brain and causes you to have suicidal thoughts. So I tried CBD after a quick research. First night, I didn’t feel a difference. I did feel a bit sleepier but I thought th…

What method did you take cbd (pill, etc..)?

It was the tinctures
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