Earlier quoted context omitted.
I've ran multiple org that are largely or almost exclusively working in Clojure(Script) and trained over a dozen folks to be proficient Clojure programmers, and have not found that any of those to be a problem. For example: you mentioned debugging serious performance problems, but the JVM has some of the most advanced instrumentation on any platform. This is actually a point subtly made in the talk: your real product…
As a counterpoint, I have had a developer who had wrote production ClojureScript tell me it was the worst of all worlds - it doesn't abstract away issues of the DOM and yet you still have to debug what was happening in JS and translate it over to Clojure. Another thing I noticed is that most developers who had to touch Clojure in my org all pretty much didn't like it at all.
Whilst Clojurescript may not solve all of your JS problems re-frame is certaily an advance over React + Redux. In fact David Nolen and Clojurescript have had a big influence on the development of React.js since Peter Hunt first introduced it.