Could password managers like 1Password (AgileBits Inc.) employ similar techniques? They seem to make very little effort in this regards. E.g. on 1Password, https://discussions.agilebits.com/discussion/101551/article-... .
This kind of mitigation really only makes sense on shared machines (such as servers). On a desktop OS, if an attacker is in a position to read memory from other processes, it's pretty much game over already. Browsers implement Spectre/Meltdown mitigation on desktop OSes because without that, JS could read secrets from other JS contexts executing in the same process. One of the mitigations is in fact to just segregate…
Not really. Password managers have access information to your other accounts in the cloud. Your desktop may not have your most valuable data.