21–30 of 41 posts
This reads like the prelude to 90% of all zombie movies - cheating death by injecting virusses, starting in the UK. It even includes a fever and neurotoxicity as side effects.
Earlier quoted context omitted.
Also, how do they move if their muscles have rotted away and they have no functioning circulatory system?
Yup. Turns out, the organs in the body have a purpose, and without them the body can't work :-) I.e. zombies are magical creatures, even less plausible than godzilla. I also curmudgeonly think that Game of Thrones lost its appeal when it stopped being about political intrigue and became yet another silly magical zombie movie.
So the very first scene of both the books and tv show?
This reads like the prelude to 90% of all zombie movies - cheating death by injecting virusses, starting in the UK. It even includes a fever and neurotoxicity as side effects.
I wouldn't worry about zombies. They violate conservation of energy laws, for one.
https://www.youtube.com/watch?v=FlK-PeCfezM
The CAR-T segment starts at 27:30.
Not mentioned here: the same results can in many cases be had from BiTEs at lower cost and without having to ship leukapheresis samples to the US in liquid nitrogen Having seen both ALL and AML patients relapsing through CAR-T, I don’t think people appreciate either the systemic load or the possibility of treatment failure that exists in real patient populations. Neither was elderly; 26yo female ALL and 5yo female AM…
It's not really fair to compare BiTEs to first gen CAR. Bispecific (or tri/quad specific) CAR have a greatly reduced rate of relapse due to antigen loss (likely what is causing most relapse in these diseases). Re: BiTEs, it's not clear they'll produce durable cures like CAR does. They're just antibodies, and will eventually be cleared. With CAR, if you can get a response, you can generate memory T-cells and control a…
I was very curious to read that it had such severe side-effects, especially the neurotoxicity. Why such a severe reaction? Does the neurotoxicity have developmental impacts for children that receive immunotherapy?
Not mentioned here: the same results can in many cases be had from BiTEs at lower cost and without having to ship leukapheresis samples to the US in liquid nitrogen Having seen both ALL and AML patients relapsing through CAR-T, I don’t think people appreciate either the systemic load or the possibility of treatment failure that exists in real patient populations. Neither was elderly; 26yo female ALL and 5yo female AM…
Why is that not also true in chemo patients?
Not mentioned here: the same results can in many cases be had from BiTEs at lower cost and without having to ship leukapheresis samples to the US in liquid nitrogen Having seen both ALL and AML patients relapsing through CAR-T, I don’t think people appreciate either the systemic load or the possibility of treatment failure that exists in real patient populations. Neither was elderly; 26yo female ALL and 5yo female AM…
> For CAR-T therapy, the common remark is “you know it’s working when the patient goes to the ICU” from tumor lysis Why is that not also true in chemo patients?
A lot of chemos are some type of poison, only slightly worse for the tumor than it is for the rest of your body. It doesn't die fast enough (and if it did, you'd be killing the rest of you too). Think months / years with chemo vs. weeks with CAR-T.
Earlier quoted context omitted.
> For CAR-T therapy, the common remark is “you know it’s working when the patient goes to the ICU” from tumor lysis Why is that not also true in chemo patients?
(note, I'm not the right type of doctor to answer this properly, but my understanding is...) A lot of chemos are some type of poison, only slightly worse for the tumor than it is for the rest of your body. It doesn't die fast enough (and if it did, you'd be killing the rest of you too). Think months / years with chemo vs. weeks with CAR-T.
I know a child with leukemia who recently started chemo. They had him on sodium bicarbonate and other medication to reduce the acidity of his urine (to compensate for the increased amount of uric acid). However, they only had him on it for the first few days of chemo. My understanding was that the bulk of the chemolysis occured in that period (though I could be mistaken).
Earlier quoted context omitted.
Yup. Turns out, the organs in the body have a purpose, and without them the body can't work :-) I.e. zombies are magical creatures, even less plausible than godzilla. I also curmudgeonly think that Game of Thrones lost its appeal when it stopped being about political intrigue and became yet another silly magical zombie movie.
Zombies aren't the only magic in Game of Thrones. They're fantasy novels. If it weren't for the zombies, the political story would just be about people fighting each other for advantage. The zombies add a tension between that and a common cause, since the threat faces them all; much like the world we live in today.