Earlier quoted context omitted.
Phase 1 study. Years from market.
...or we could just start eating Pomegranates?
who doesn't?
Pomegranate compound with anti-aging effects passes human trial
11–20 of 52 posts
Re: Pomegranate compound with anti-aging effects passes human trial
#12Re: Pomegranate compound with anti-aging effects passes human trial
#13Earlier quoted context omitted.
Phase 1 study. Years from market.
...or we could just start eating Pomegranates?
We can "just" start eating Pomegranates, absolutely. Personally, I find them pretty tasty, and they remind me of the Greek myth of Persephone's abduction by Hades. So I'm all for them.
But how much you'd need to eat for a clinically noteworthy benefit is the question. That's what the follow-on studies are for.
Re: Pomegranate compound with anti-aging effects passes human trial
#14The Wikipedia page for the compound being discussed has a table of food and drink sources for it.
https://en.m.wikipedia.org/wiki/Urolithin_A
Not everyone’s body can create UA from these natural sources so the idea is to just make a pill for it that will work on anyone.
Re: Pomegranate compound with anti-aging effects passes human trial
#15Pomegranate fasting and/or Aronia ("chokeberry") fasting (30 to 60 days) are incredible healers of all "diseases" known to man kind. Do your own research.
Re: Pomegranate compound with anti-aging effects passes human trial
#16pomegranates and raspberries as well
"A compound called urolithin A (UA) was the focus of the study, after previous experiments with it showed promise in extending the lifespans of worms and mice. The compound appears to fight aging by improving the function of mitochondria – the energy-producing part of a cell – in a way similar to the benefits of exercise. While it's not found naturally in any known food, biomolecules in fruits like pomegranates and raspberries do break down into UA in the human gut"
Here's the study https://sci-hub.tw/https://www.nature.com/articles/s42255-01...
Yellow raspberries seems to contain bigger amounts of ellagic acid than pomegranates
Re: Pomegranate compound with anti-aging effects passes human trial
#17Earlier quoted context omitted.
Phase 1 study. Years from market.
...or we could just start eating Pomegranates?
If they’ve raised capital for a series of clinical trials, you can reasonably assume the doses at which they expect to see clinical effects are much higher than you’re likely to get just from food ingestion - otherwise their competition would just be pomegranate juice pills or something, sold as a food supplement and requiring no trials of safety or efficacy. They’d never have been able to raise a cent.
In other words, no one would fund a penicillin trial if they thought people could get by eating moldy bread from GNC.
Re: Pomegranate compound with anti-aging effects passes human trial
#181) Metabolic side effects tend to be slow and subtle. Vioxx caused increased heart attacks over time. Passing a phase 1 safety trial is fine and dandy, but it’s a far cry short of long-term safety in a drug targeting metabolism, and it’s not even where most drugs fail. 2) Lab evidence for a biomarker for a metabolic process is so far short of evidence of clinical improvement that it’s a joke. I will never stop deridi…
Do all "we have identified a dose range that doesn’t immediately sicken people” studies make it to Nature journals ?
Only if the right people were involved in the study.
Re: Pomegranate compound with anti-aging effects passes human trial
#19Earlier quoted context omitted.
That seems overly dismissive of the finding on mitochondrial activity: " The team then assessed the efficacy of UA by looking at cellular and mitochondrial health biomarkers in the participants' blood and muscle tissue. The results were compelling: UA stimulates mitochondrial biogenesis—the process by which cells increase mitochondrial mass—in the same way as regular exercise. UA is the only known compound that re-es…
Biomarkers are not a clinical effect, this doesn't tell you whether this compound has any anti-aging effects. This is still an early point in the development of a drug.
Exactly. Promising biology != clinical activity.
Re: Pomegranate compound with anti-aging effects passes human trial
#20So there are products on the market already or no one has a product on the market yet?
Quite possibly pomegranate... It's unclear how much it has though.
From the Wikipedia link someone else posted it looks like 100g of pomegranate is approximately 250mg, so 200g pomegranates a day to get to the point where they saw any (non clinical still) effects.