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Ask HN: What can I do to accelerate scientific research?

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Re: Ask HN: What can I do to accelerate scientific research?

#71
Note: The following is an earnest suggestion and not just a recruiting plug, but it is also a recruiting plug. If this is not an appropriate place for this content then comment and I'll remove (I do not frequently HackerNews)!

Personally, I believe the highest leverage thing we can do to promote scientific research is to help connect the dots between related discoveries in the service of bringing new ideas to commercialization/impact as quickly and reliably as possible. I joined Citrine (https://citrine.io/platform/) a few years ago thinking that we would help accelerate research by direct support - building simulation, data, and machine learning tools for scientists. It became clear very quickly that the community was already in a pretty strong position (smart cookies, those research scientists) on that front. The biggest opportunity turned out to be scaling expert knowledge - bridging the no man's land from ideation to scale-up, integration, and manufacturing. At Citrine, we're building infrastructure that helps researchers contribute to an organization-wide knowledge graph capable of supporting inference in the scale-up or manufacturing context based on relationships learned in the R&D phase. This fundamentally changes the ROI calculus for basic research because it can plausibly support the entire product life cycle.

If this sounds exciting to you, then consider joining us! We just raised a Series B and are growing quickly.

If you have an applied math and software eng. background and want to help generalize and scale our property inference infrastructure, then I think you'd enjoy working with me and my team in SSE: https://citrine.io/careers/#scientific-software-engineer.

If you have a backend software eng background and want to build distributed services for scientists and engineers at some of the biggest materials and chemicals companies in the world, join us in engineering: https://citrine.io/careers/#sr-backend-software-engineer.

Re: Ask HN: What can I do to accelerate scientific research?

#73

> indexing all open research with free unlimited access, similar to arxiv-sanity.com but better This space is pretty crowded, in my opinion. I don’t know much about biology, but I can tell you that in materials, it’s all about data. The materials design problem and predicting new materials comes down to knowing properties of other materials. A lot of progress has been made by using datasets generated by quantum mecha…

https://citrine.io/ You might find this company interesting.

[deleted]

Re: Ask HN: What can I do to accelerate scientific research?

#74
Cochrane reviews.

Wiki (ISH) based.

Does the graph, this alone might be enough to help science and can be used to kick-start to the site (do you want to open source your graph and data questions)

I'd guess you have to have multiple graphs for topics due to disagreements that can't be solved. But this can't be guessed, would need to be worked out. I think people would get reputations and this would push forward topics.

This is mostly for medicine... But might expand.

Re: Ask HN: What can I do to accelerate scientific research?

#75
>>> Indexing all open research

I'd also check out analytics platforms such as VIVO. End goal is a universal workflow for all research, discovery and collaboration. Solving this problem will have immediate impact. For example, computational epidemiology and containing Ebola outbreaks in "hot zones" hundreds of miles apart.

Web of Science

https://clarivate.com/products/web-of-science/

Re: Ask HN: What can I do to accelerate scientific research?

#76

I have a request. Somebody needs to make matplotlib, but with a C API and lots of language bindings instead of only a python API. For example when I'm writing rust, my best option is to use a Python interop library that calls matplotlib...

Matplotlib is better than nothing, but... as I understand it, it was inspired by Matlab's plotting - and therefore is a bit quirky when translated to the Python paradigm. I use it tho.

I think having a built-in web server via a visualization library that shows the graphs etc in a browser is 'optimal' -- because then, the whole crap of e.g. dealing with Tkinter to make your windows goes away. You achieve OS independence, and could even use lynx for text-only.

The Python visualization space is vast. I believe 'something better' will shake out in the next few years.

Re: Ask HN: What can I do to accelerate scientific research?

#77

This is a pipe dream of mine, but I would love a Wikipedia of null results: nullpedia! Nobody publishes null results bc they’re not exciting, but I think a lot of NSF money would be saved if “failed” experiments were aggregated somewhere in a searchable way. There’s lot of questions. How to organize it? How to encourage participation? How to maximize usefulness while at the same time minimizing volunteer effort? How…

Great idea, would love to see it.

Related, there were journals like this at some point, e.g. International Journal of Negative & Null Results, or ournal of Articles in Support of the Null Hypothesis, and I think at least one more. Not sure how they fare, though.

Re: Ask HN: What can I do to accelerate scientific research?

#78
Learning a lot how science actually works and how flawed it is I came to the conclusion that the biggest boost in scientific progress you could ever achieve is by eliminating science waste and doing more good science.

There are a few tiny steps in the right direction, but it's frustratingly slow. Once you understand a phenomena like publication bias it's hard to swallow that there are still empirical studies published without preregistration. There are so many studies published with such low quality that it's a complete waste, because the likelyhood that they're some statistical fluke is much higher than that they tell the truth.

Though the problems are known since a while, little has changed: https://journals.plos.org/plosmedicine/article?id=10.1371/jo...

Re: Ask HN: What can I do to accelerate scientific research?

#79
So as someone working in application of medicines, I'd agree with the comments that say those of us doing these things have learn to make code work, but are not software engineers (and would not claim to be). This means that if you can improve the tools that are used (and don't care about making a return), the leverage would be massive.

I imagine it isn't trivial (otherwise it would have been done by now), but imagine if R was automatically parallel processing; seldom is the code in my field worth figuring out how to make it parallel, but if it was automatically, then a hell of a lot of time would be saved! I know there are two packages that kind of make it work, but so far I've yet to hit a threshold making it worth it (I just leave thigns running overnight).

Abstract from that to projects like Zotero and you can see how you could have an impact on a lot of people by enabling them to do what they do.

Re: Ask HN: What can I do to accelerate scientific research?

#80

This is a pipe dream of mine, but I would love a Wikipedia of null results: nullpedia! Nobody publishes null results bc they’re not exciting, but I think a lot of NSF money would be saved if “failed” experiments were aggregated somewhere in a searchable way. There’s lot of questions. How to organize it? How to encourage participation? How to maximize usefulness while at the same time minimizing volunteer effort? How…

To do this, it somehow needs to gain the reputation of a publication but also not encourage people doing just frivolous research (at least not on their own dime).

But I think this kind of thing would be INSANELY useful. Especially if data was attached. (This could possibly help with the above problem because reputations develop).

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