Magnesium and major depression (2011)

I mean the fact that it works as a treatment. We don't have much more than doing a blind test and checking improvement to test causality. There are so many real world factors that elimination wouldn't work.

I see that you like Jung so I'm sure you're aware that there's more than neurochemistry that can influence it, but when talking about drugs, incentives seem to be aligned such that one should expect patented substances to have the most papers showing positive results vs something cheap and readily available.

Plus I thought you were only basing this N=1 on blood tests so I didn't like dismissal of paper based on that, thus the tone of my prev reply, I'm sorry about that.

I would wager it's a combination of factors:

1. In general, the north american diet is disgraceful.

2. Consumerism and brainwashing people into believing that they can only be happy when they achieve X, Y or Z, does nothing for people's emotional emptiness.

3. The constant barrage of shit news, most of which is largely irrelevant to most of our lives, most of the time.

4. The constant threat of automation and off-shoring meaning that people never feel secure about their income stream unless they specifically work in an industry where their ability to generate their income stream is unrelated to these constant threats.

5. Inflation of living costs escalating at a rate beyond inflation of income.

6. The polarization making people feel isolated from one another instead of connected. Nobody can talk about anything any more without fear of offending someone, being politically incorrect, being ostracized or vilified.

7. The reported growing financial disparity where the 2% have 98% of the wealth while the 98% share the other 2% and the constant message that it's only going to get harder to be able to cross that chasm.

8. Corporations subverting politics for their own profits instead of the good of the people.

The list goes on ad nauseum.

I firmly believe if the world stops behaving like assholes, learns to eat properly and talks to one another to a level that find connection instead of a divide. The depression is just going to get worse and worse until suicide becomes an epidemic.

I hope this issue gets more attention. We're so undernourished when it comes to Magnesium. Also, closely related is Calcium. Calcium and Magnesium work closely together in the body for huge number of functions related to brain health. Of particular importance is the ratio of calcium to magnesium. A Significant portion of the population has their calcium to magnesium ratio way too high, something like 10 to 1 or higher. This is not only due to too little magnesium but also due to way too much calcium. It's not commonly known in the US (because big food companies run the USDA recommendations), but you're only supposed to get 500mg of calcium a day, not 1000mg like the USDA recommends. There are so many studies that show that 1400mg+ is approaching a danger zone. this is exacerbated by unusually low magnesium levels.

If you're looking to get more magnesium into your body, I'd recommend whole foods rather than supplements. Supplements are often not absorbed by the body. Whole foods high in magnesium include: leafy greens, nuts (especially cashews), oatmeal, whole grains, beans. and if you want to find more high nutrient foods try my nutrient based food search: https://kale.world/c (put the selector on magnesium)

> Hemp is a weed and was growing prolifically all over the US until the 1920's and 1930's, when it was outlawed. Free range cattle still is a big thing but was even larger then. Most of the beef in the nation consumed hemp 2nd hand by eating the domestic and wild animals that grazed on this wild growing weed

> https://en.wikipedia.org/wiki/Hemp

1. The link you provided states that hemp contains varying amounts of CBD, and does not claim that cattle have ever consumed any CBD.

2. Even if cattle do/did consume CBD, the link does not claim that any of that CBD is passed down to humans consuming beef--there's no evidence in that link that beef from cattle who consume CBD contains any CBD.

> It isn't hard to extrapolate that humans have been digesting the weed and cannabinoids for a long time and it is an integral part of the human system

> Of course you can say humans and the plants evolved parallel and they arent related. I have no evidence to prove otherwise but typically when you see similar systems in the same ecosystem they are related.

1. I don't buy the claim that "typically when you see similar systems in the same ecosystem they are related". Proving such a claim would require a wide survey of a bunch of ecosystems to prove a hypothesis that doesn't really build toward any theory: in short, this isn't even a good hypothesis, let alone a hypothesis which is likely to have been tested.

2. Even if we accept hypothesis 1 is true, that doesn't show what the relation is--it doesn't show that humans have been digesting cannabinoids. There's lots of evidence that cannabinoid receptors are involved in hunger and metabolism, and while I won't claim to fully understand that, I think we can agree that humans need to eat to survive, so there are some pretty clear reasons for the cannabinoid receptor system existing in humans that have nothing to do with cannabinoids originating in plants. Also, humans aren't the only species with cannabinoid systems. It's just as possible that humans or another mammal are integral parts of cannabinoid survival than the inverse.

I can certainly appreciate the romantic aesthetic of a plant coevolving with humans to expand our minds or some such, but the fact that it's such an aesthetically pleasing hypothesis should be recognized as bias, making me doubly skeptical.

How significant is that portion? Have there been any large scale clinical studies recently on calcium and magnesium levels in the population?

Please cite your sources regarding the recommended calcium intake.