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Magnesium and major depression (2011)

ncbi.nlm.nih.gov

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Re: Magnesium and major depression (2011)

#111

Post by billman »

opportune wrote: post #102

The first author has a publication called "zinc lozenges as a cure for the common cold" here: https://www.ncbi.nlm.nih.gov/pubmed/19906491 and given that the author has his own "research institute" I'm highly skeptical of this guy's ability to do science. Seems like some kind of crackpot I mean seriously look at this website: https://m.george-eby-research.com/app/welcome/5310242/36/

FYI, The title of his paper is "Zinc lozenges as cure for the common cold – A review and hypothesis". I haven't read it, but the title seems reasonable.

Re: Magnesium and major depression (2011)

#112

Post by opportune »

billman wrote: post #111
opportune wrote: post #102

The first author has a publication called "zinc lozenges as a cure for the common cold" here: https://www.ncbi.nlm.nih.gov/pubmed/19906491 and given that the author has his own "research institute" I'm highly skeptical of this guy's ability to do science. Seems like some kind of crackpot I mean seriously look at this website: https://m.george-eby-research.com/app/welcome/5310242/36/

FYI, The title of his paper is "Zinc lozenges as cure for the common cold – A review and hypothesis". I haven't read it, but the title seems reasonable.

In the publicly visible abstract it says:

" Zinc lozenges slowly dissolving in the mouth over a 20-30 min period releasing adequate iZn (18 mg) used each 2h are hypothesized to shorten common colds by 6-7 days, which is a cure for the common cold."

Re: Magnesium and major depression (2011)

#113

Post by joshgel »

opportune wrote: post #102

The first author has a publication called "zinc lozenges as a cure for the common cold" here: https://www.ncbi.nlm.nih.gov/pubmed/19906491 and given that the author has his own "research institute" I'm highly skeptical of this guy's ability to do science. Seems like some kind of crackpot I mean seriously look at this website: https://m.george-eby-research.com/app/welcome/5310242/36/

Medical view: Magnesium is one of the most ordered tests in the hospital setting. Definitely in top 10 most places, probably top 5. Almost certainly over ordered. We have tons of data from which to draw conclusions. Not that we can assume that just because the data is there it has already been studied, but if there was a true signal there it would be very easy to study and I’d be surprised if it hadn’t been.

Very few otherwise healthy people have low magnesium levels. The reasons are usually related to severe kidney dysfunction, severe malnutrition, certain blood cancers/blood disorders, alcohol abuse (also because of malnutrition), and being on diuretics.

Re: Magnesium and major depression (2011)

#114

Post by DoreenMichele »

kmmlng wrote: post #19

I once tried supplementing magnesium while in the midst of moderate depression. Interestingly enough, the effect was not relief, but rather major, absolutely crushing depression (i.e. cannot get out of bed all day depression). I went back to moderate depression after stopping the supplementation and a subsequent second attempt brought back the major depression. By that point I gave up on the whole thing. Anyone have…

maybe some insight that might explain this?

Some thoughts:

1. You may have taken a form of supplement you don't tolerate well. I have trouble with sulfur. A lot of iron supplements are sulfur based. They cause negative side effects for me.

2. In order to be properly absorbed, magnesium needs to be taken with some other things, like calcium, vitamin D and vitamin K. Maybe you weren't absorbing it well because you weren't taking it with these other things.

3. Maybe you have some unidentified genetic quirk that impacts the processing of magnesium.

4. A nutritional approach to addressing health issues is a case of "Things get worse before they get better." A lot of people use the term "healing crisis" to describe this process. If you think you have never heard of such, think again. The best known form of this phenomenon is drug withdrawal.

5. You aren't magnesium deficient, so you were actually causing yourself an overdose of magnesium. There is some other explanation for your depression. Magnesium deficiency is not it.

Re: Magnesium and major depression (2011)

#115

Post by phkahler »

cik2e wrote: post #52
phkahler wrote: post #24

Earlier quoted context omitted.

Magnesium glycinate is even better. Glycine turns out to be important too, but it's just used as filler.

Glycine’s not a filler in this instance. It’s used to aid absorption [1]. Mag glycinate is one of the only worthwhile forms of magnesium for supplementation, unless you’re using it as laxative. The latter being caused by gut irritation from unabsorbed magnesium. But yes, glycine also has many of its own benefits. Including a very interesting theory regarding life extension due to its interaction with methionine. [2]…

Thanks for that second link. I had read about glycine for sleep, mood, bipolar and schizophrenia (via Glenn Close family study) but not for possible life extension. It does improve my own mood with a dose of several grams per day but the best mental effect seems to be the day I stop taking it. Lower dose does not produce that, it seems to be a dynamic response. So it seems important but complicated, but that's just my anecdote.

Re: Magnesium and major depression (2011)

#116

Post by kerkeslager »

mboto wrote: post #11

I have found that taking Magnesium is like turning a switch on in my head and I'm suddenly happy again. I don't get upset or angry in the same way, I'm more patient and my thoughts are not obsessive. Magnesium is best taken with calcium and vitamin D as both are used in the uptake of magnesium. I have found that processed foods, alcohol, caffeine and sugar all make me worse, but magnesium gives me the will power to c…

> I have found that taking Magnesium is like turning a switch on in my head and I'm suddenly happy again. I don't get upset or angry in the same way, I'm more patient and my thoughts are not obsessive.

> Magnesium is best taken with calcium and vitamin D as both are used in the uptake of magnesium.

There are a bunch of studies which have found correlations between vitamin D and depression and (stronger) correlations between vitamin D and seasonal affective disorder.

If your supplementation is working for you, there's no reason to change it, but there's a fairly obvious alternate explanation for the phenomena in the fact that you're also supplementing Vitamin D.

Re: Magnesium and major depression (2011)

#117

Post by arkades »

kevstev wrote: post #85

I started taking magnesium supplements about 9 months ago, not for any depression issues, but more for muscle issues. I had a weird leg muscle injury a few years ago that I never really got a proper diagnosis for that happened when doing some light hiking. In doing my own research on that, a condition similar to my symptoms came up, and one of the causes was a magnesium deficiency. I had a few other minor ailments co…

200mg is a decent bump on average daily intake (360mg), and mag isn’t managed as well as other ions. If you don’t already, please have your doc check your mag levels every couple of months while you do this. Hypermagnesemia is no joke.

Re: Magnesium and major depression (2011)

#118

Post by arkades »

batter wrote: post #99
kevstev wrote: post #85

I started taking magnesium supplements about 9 months ago, not for any depression issues, but more for muscle issues. I had a weird leg muscle injury a few years ago that I never really got a proper diagnosis for that happened when doing some light hiking. In doing my own research on that, a condition similar to my symptoms came up, and one of the causes was a magnesium deficiency. I had a few other minor ailments co…

If you're playing with magnesium/calcium i think boron should be included as well. It will allow you to utilize magnesium/calcium.

Do you have any sources for that statement? I haven’t read anything to that effect, and I’d be interested in finding out more.

Re: Magnesium and major depression (2011)

#119

Post by Tharkun »

joshgel wrote: post #113
opportune wrote: post #102

The first author has a publication called "zinc lozenges as a cure for the common cold" here: https://www.ncbi.nlm.nih.gov/pubmed/19906491 and given that the author has his own "research institute" I'm highly skeptical of this guy's ability to do science. Seems like some kind of crackpot I mean seriously look at this website: https://m.george-eby-research.com/app/welcome/5310242/36/

Medical view: Magnesium is one of the most ordered tests in the hospital setting. Definitely in top 10 most places, probably top 5. Almost certainly over ordered. We have tons of data from which to draw conclusions. Not that we can assume that just because the data is there it has already been studied, but if there was a true signal there it would be very easy to study and I’d be surprised if it hadn’t been. Very few…

I was under the impression that it was really hard to detect magnesium deficiency in bloodwork, because most of it is either supposed to be in our bones or cells, so a blood test doesn't paint a complete picture of total Mg stores.
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