Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

Magnesium and major depression (2011)

ncbi.nlm.nih.gov

Post reply on HN
Print view View original

101–110 of 235 posts

Re: Magnesium and major depression (2011)

#101

Post by SirensOfTitan »

kevstev wrote: post #85

I started taking magnesium supplements about 9 months ago, not for any depression issues, but more for muscle issues. I had a weird leg muscle injury a few years ago that I never really got a proper diagnosis for that happened when doing some light hiking. In doing my own research on that, a condition similar to my symptoms came up, and one of the causes was a magnesium deficiency. I had a few other minor ailments co…

What kind of Magnesium are you taking? There’s a huge differential of bioavailability of different magnesium types.

Re: Magnesium and major depression (2011)

#102

Post by opportune »

The first author has a publication called "zinc lozenges as a cure for the common cold" here: https://www.ncbi.nlm.nih.gov/pubmed/19906491 and given that the author has his own "research institute" I'm highly skeptical of this guy's ability to do science. Seems like some kind of crackpot

I mean seriously look at this website: https://m.george-eby-research.com/app/welcome/5310242/36/

Re: Magnesium and major depression (2011)

#103

Post by ddorian43 »

wolco wrote: post #94
ddorian43 wrote: post #50

Earlier quoted context omitted.

Glycinate is ~most used/benefit/cost I think (i do). There's also threonate which is in a weird state with effects,withdrawals,price etc. I have some and still haven't tried it.

Glycinate seems to absorb well. 1/2 a capsule seems to do wonders anymore too tired/nervous

You have to speak in miligrams.

Re: Magnesium and major depression (2011)

#104

Post by wolco »

kmmlng wrote: post #19

I once tried supplementing magnesium while in the midst of moderate depression. Interestingly enough, the effect was not relief, but rather major, absolutely crushing depression (i.e. cannot get out of bed all day depression). I went back to moderate depression after stopping the supplementation and a subsequent second attempt brought back the major depression. By that point I gave up on the whole thing. Anyone have…

Two thoughts

GI changes / issues

You don't have enough vit-d to bind with

Re: Magnesium and major depression (2011)

#105

Post by Charybdis »

ehosca wrote: post #47
peteradio wrote: post #33

Earlier quoted context omitted.

Where do you find such things?

https://www.amazon.com/Trace-Minerals-Research-Concentrace-M...

I've personally had great success with this particular product. At the end of a long day of coding, when my brain seems "burnt out"/fuzzy, 20-30 drops of this in a glass of water has an almost-immediate and noticeable impact (most of the time).

Re: Magnesium and major depression (2011)

#107

Post by Nasrudith »

I have some personal experiences to share - anecdotal and not that scientific.

I found it slightly helpful in my own treatment of depression. Not a miracle cure - it was suggested essentially because Proton Pump Inhibitors I am already on were known to worsen/cause it. In my case it seems to make medication a bit more effective and helped thinking a little bit. A few times when I ran out for a week or so waiting for the next bulk order to arrive it eventually caused a mild worsening of mood that went away when resumed. I don't know if I ever actually had deficiencies because needle phobia has meant avoidance such that I can only list my blood type as a question mark.

Re: Magnesium and major depression (2011)

#108

Post by DoreenMichele »

The onset of depression has greatly increased in incidence, and it is affecting people much earlier in their lives during the late 20th century and early 21st century than before the 20th century (Meyer and Quenzar, 2005). The reasons for these findings are not quite clear, but inadequate dietary Mg is prevalent in America and is the most likely cause. There is probably a real increase in depression, coupled with a change in diagnostic habits, which has to do with the element of stigma. Lower stigma leads to a higher rate of diagnosis.

Somatopsychic medical effects are very real. I've gotten very good results with addressing nutritional deficiencies as a first line of defense for issues that often present as mood or mental health issues.

But I don't think you can reasonably conclude that magnesium deficiency is The explanation for increased prevalence of depression in a world that has had so many profound changes.

Things are more crowded. Most people now live in cities instead of rural environments. Among other things, this means people are subjected to much noisier conditions.

We have far, far better information about the world than we used to. The 24/7 news cycle is incredibly stressful, if only because most "news" is bad news.

There are just so very many confounding factors, no, you can't reasonably conclude that this one singular factor is the sole explanation or primary explanation. That's ridiculous.

Re: Magnesium and major depression (2011)

#109

Post by will_brown »

kevstev wrote: post #85

I started taking magnesium supplements about 9 months ago, not for any depression issues, but more for muscle issues. I had a weird leg muscle injury a few years ago that I never really got a proper diagnosis for that happened when doing some light hiking. In doing my own research on that, a condition similar to my symptoms came up, and one of the causes was a magnesium deficiency. I had a few other minor ailments co…

I also began taking magnesium (a few years ago) for running, not depression.

I probably log 50-80 miles per week and low magnesium levels are notoriously low in endurance athletes. I also follow a ketosis diet for as many as 6 months at a time, low magensium is also common with Keto diet.

I take up to 10 vitamin/mineral supplements, but kind of cycle them at various times. It’s impossible to really pinpoint anything, but I tend to think I personally got great benefits to my running through the addition of fish oil, vitamin B, vitamin D and magnesium. Specifically I feel benefits to both energy and anti-inflammation, at one point I scaled up to a half marathon everyday and was never even sore, whereas previously I’d run maybe 5 times a week and sometimes be stiff the next day following 7 mile runs. It’s definately not magic, these supplements don’t run the miles for me, but I do feel better during the runs, recover better, and it just creates this feedback loop where it feels I am growing/improving.

Re: Magnesium and major depression (2011)

#110

Post by okmokmz »

opportune wrote: post #102

The first author has a publication called "zinc lozenges as a cure for the common cold" here: https://www.ncbi.nlm.nih.gov/pubmed/19906491 and given that the author has his own "research institute" I'm highly skeptical of this guy's ability to do science. Seems like some kind of crackpot I mean seriously look at this website: https://m.george-eby-research.com/app/welcome/5310242/36/

Wow, that website has a lot of red flags. The second line alone, "this is a multi-gigabit sized site," is enough to make me doubt the info on that page. This NYT article from 1995 says he is a "city planner turned self-educated pharmacologist" so I'd be surprised if any of his "research" was properly done or reached accurate conclusions

https://www.nytimes.com/1995/05/29/business/patents-751395.h...

Post reply on HN