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Magnesium and major depression (2011)

ncbi.nlm.nih.gov

21–30 of 235 posts

Re: Magnesium and major depression (2011)

#21

I'm quite skeptical on supplements, but I have to say that Magnesium helps me sleep like a baby and feel much more relaxed generally.

Also very skeptical, and I try to test carefully. So far, it seems that Passionflower extract does boost my sleep quality and helps with early-morning-waking style insomnia. In the evening, CBD helps me downshift to a relaxed "end-of-day" mode that makes falling asleep much easier. Magnesium's next on my list.

Re: Magnesium and major depression (2011)

#22
post #15

Earlier quoted context omitted.

I generally agree with you, but lithium is also used to treat bi-polar disorder (among others) and it was discovered by accident. People used to recommend it without any data supporting it. I suspect this is how most treatments start

>lithium [...] was discovered by accident. No it was not. Development of treatment with lithium was very much a part of psychiatric normal science.

Discovery by accident is normal psychiatric science. Lithium came into use to treat gout, depression being seen a a "brain gout" [1]. The first MAO inhibitor was developed to treat tuberculosis, but doctors noticed that their patients were unusually cheerful [2] - and it was only synthesized in the first place because there was a lot of hydrazine left over from the V2 rocket programme!

[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712976/

[2] https://www.ncbi.nlm.nih.gov/pubmed/19442174

Re: Magnesium and major depression (2011)

#23
I take magnesium in the form of trace mineral drops. These are de-salted sea water deposits. Besides magnesium they contain other rare trace minerals which would otherwise be difficult to obtain, particularly lithium which has quite strong evidence of mellowing mood.

The liquid form leads me to believe they absorb well but not sure if that's actually true.

Edit to say I believe these drops have reduced my anxiety and improved relaxation. If nothing else I sleep better due to the mg (no more Jimmy legs).

Re: Magnesium and major depression (2011)

#26

Earlier quoted context omitted.

Most cheap magnesium is magnesium carbonate which is least effective and causes diarrhoea (should be taken with calcium to prevent that). Magnesium aspartate is sometimes prescribed as "working one", but can be neurotoxic (according to this paper).

I take magnesium bis-glycinate, it's well absorbed and has no serious side effects.

Me too. I haven't tried other versions which are recommended by this paper, but I can recommend bis-glycinate. I tried carbonate and it didn't work for me. Recommended dose is 150mg/day, but I've found I need even 300mg/day (heavy cofee drinker).

Re: Magnesium and major depression (2011)

#27

Earlier quoted context omitted.

Most cheap magnesium is magnesium carbonate which is least effective and causes diarrhoea (should be taken with calcium to prevent that). Magnesium aspartate is sometimes prescribed as "working one", but can be neurotoxic (according to this paper).

I take magnesium bis-glycinate, it's well absorbed and has no serious side effects.

Glycine on it's own is also a thing. It tastes sweet so you can add it to a drink or food without problem.

Re: Magnesium and major depression (2011)

#29
post #19

I once tried supplementing magnesium while in the midst of moderate depression. Interestingly enough, the effect was not relief, but rather major, absolutely crushing depression (i.e. cannot get out of bed all day depression). I went back to moderate depression after stopping the supplementation and a subsequent second attempt brought back the major depression. By that point I gave up on the whole thing. Anyone have…

I didn't have that but it sure made me extra sleepy during the day when I took too much initially. After reducing the dose it was fine.

Re: Magnesium and major depression (2011)

#30
post #15

Earlier quoted context omitted.

I generally agree with you, but lithium is also used to treat bi-polar disorder (among others) and it was discovered by accident. People used to recommend it without any data supporting it. I suspect this is how most treatments start

>lithium [...] was discovered by accident. No it was not. Development of treatment with lithium was very much a part of psychiatric normal science.

From Wikipedia (https://en.wikipedia.org/wiki/Lithium_(medication)): "Cade needed soluble urate for a control. He used lithium urate, already known to be the most soluble urate compound, and observed that it caused the rodents to become tranquil."

That looks to me like a surprise discovery.

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