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With greater longevity, the quest to avoid infirmities of aging is more urgent

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Re: With greater longevity, the quest to avoid infirmities of aging is more urgent

#11
post #7

Yes we can. Calorie restriction is well known slowing biological aging process. Sources: https://en.wikipedia.org/wiki/Calorie_restriction

The second paragraph on that page:

> In humans, the long-term health effects of moderate caloric restriction with sufficient nutrients are unknown.

Re: With greater longevity, the quest to avoid infirmities of aging is more urgent

#12
post #10
post #7

Yes we can. Calorie restriction is well known slowing biological aging process. Sources: https://en.wikipedia.org/wiki/Calorie_restriction

The existing research on CR seems to indicate that the closer you get to human-like animals the lesser it works. It worked very well in small organisms, once you go to apes the results are much less clear: https://www.theverge.com/2017/1/17/14287708/caloric-restrict...

One thing is for sure, the average Western diet has so many calories than most people could probably do with a little restriction. (Not even to do anything special, just to return to a healthy state.)

Re: With greater longevity, the quest to avoid infirmities of aging is more urgent

#13
post #6

Earlier quoted context omitted.

I'm extremely interested in the topic (as I get older but happen to like living). However some people seem to think De Grey is a bit of a crackpot?

Could be but he also published a well-received paper on graph coloring, so at least he's not stupid. https://arxiv.org/abs/1804.02385

Newton published plenty of crackpot works on Alchemy and Biblical exegesis in addition to the Principia. Smart people often say the stupidest things.

Re: With greater longevity, the quest to avoid infirmities of aging is more urgent

#15
post #5

Earlier quoted context omitted.

I'm extremely interested in the topic (as I get older but happen to like living). However some people seem to think De Grey is a bit of a crackpot?

Well, we've had some wonderful crackpots through the ages. Tesla comes to mind. Whatever you think about his idea of escape velocity you can't doubt the engineering approach he advocates makes sense. Solve these 7 problems [1] and there will be no reason the organism should die. [1] https://en.wikipedia.org/wiki/Aubrey_de_Grey#The_seven_types...

I can doubt of the engineering approach he advocates, because I am aware that people like me is completely an outsider in this branch of science and I cannot differentiate a charlatan from an actual scientist.

You could fool a person ignorant enough in a speciality with statements such as:

- To fly we just need a way to defeat gravity.

- To resurrect a body we just need to insufflate the soul back to the body.

- To make a head transplant we just need to reconnect the nerves and wait the meat to glue.

- An artificial intelligence will solve our company's problem.

This ver same person could be highly skilled or smart in other aspects. The more technical or scientific we sound the more a subject will give authority to the charlatan.

I ignore if these statements made by this person are overall valid, if the list is exhaust and if the things there are additional factors I ignore. Even in such case we also ignore the deepness of the problem and circumstances related.

Most of people, including myself, are no biologist or cryonogists and have not enough knowledge on that level, in addition it is in the human nature to have high hopes in self perpetuating ourselves. Thats the perfect ground for charlatans to grow.

Re: With greater longevity, the quest to avoid infirmities of aging is more urgent

#16
post #9

Anyone interested in the idea of living longer (without the detrimental effects of aging) should check out any Aubrey De Grey talk/video/interview.

Or get a gym membership, actually use it and eat less crap. This may only give you a few years, but chances that it'll actually work are much higher.

That's my plan. I've got the gym membership and use it often.

I struggle mightily with eating less crap, though. (Especially chocolate.) Food is one of the great pleasures in life, and I haven't found really healthy food to be a good replacement for tasty junk.

Maybe advances in food production will bring hope?

Re: With greater longevity, the quest to avoid infirmities of aging is more urgent

#17
post #11
post #7

Yes we can. Calorie restriction is well known slowing biological aging process. Sources: https://en.wikipedia.org/wiki/Calorie_restriction

The second paragraph on that page: > In humans, the long-term health effects of moderate caloric restriction with sufficient nutrients are unknown.

It's not because it's unknown we should assume there is no effect (positive or negative). Rather, it's worth exploring.

Re: With greater longevity, the quest to avoid infirmities of aging is more urgent

#18
post #17
post #11

Earlier quoted context omitted.

The second paragraph on that page: > In humans, the long-term health effects of moderate caloric restriction with sufficient nutrients are unknown.

It's not because it's unknown we should assume there is no effect (positive or negative). Rather, it's worth exploring.

It's not because it's unknown we should assume this effect scales linearly, either..
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