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Stem cell transplant has cured HIV infection, say doctors

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Re: Stem cell transplant has cured HIV infection, say doctors

#21
post #8
post #7

Earlier quoted context omitted.

It's real, but not practical. The risk of death during a transplant like this is as high as 10%, because it involves completely knocking out the immune system.

I think most AIDS patients would gladly take that 10% chance.

AIDS has actually become manageable, and most HIV+ patients in the developed world die of other causes (cancer, aging, etc.) instead of AIDS. So I wouldn't be too sure.

Re: Stem cell transplant has cured HIV infection, say doctors

#23

Stem Cell Research must be allowed.

The difficulty with using HIV as your use-case argument is last I checked, most religious organizations considered HIV to be God's scourge on homosexuals. e.g. they are not particularly worried about getting rid of it. (I'm not just being snarky or sarcastic)

This is certainly not true with mainstream Christianity in the UK, although sadly some loud voices can be heard agreeing with what you say.

As just one example, Christian Aid, a large UK charity which works to end poverty and injustice around the world clearly states that HIV is a virus, not a moral issue: http://www.christianaid.org.uk/resources/policy/HIV_AIDS.asp...

Re: Stem cell transplant has cured HIV infection, say doctors

#24

Stem Cell Research must be allowed.

The difficulty with using HIV as your use-case argument is last I checked, most religious organizations considered HIV to be God's scourge on homosexuals. e.g. they are not particularly worried about getting rid of it. (I'm not just being snarky or sarcastic)

If we need to get rid of religion first, so be it. Win-win.

Re: Stem cell transplant has cured HIV infection, say doctors

#25
post #10

Stem Cell Research must be allowed.

The trick is that there are many sources of stem cells, some controversial, some most definitely not. For instance: baby teeth[1]; amniotic fluid[2]; embryos[3]; fetuses[4]; and others. There are even "pluripotent"[5] cells which have similar attributes, which have even been created from skin cells. "Stem Cell Research must be allowed": of course. Blanket bans are ignorant of the sources, and are effectively idiotic…

What about human milk? I know I have read articles about breast milk/colostrum containing stem cells. Would this be an easier source than those mentioned in the wikipedia page? Of course, you still have the problem of finding lactating women willing to donate their milk in the name of science...

(Disclaimer: I know nothing about stem cells. I merely have an interest in the science of breast milk as a nursing mother. :) )

Re: Stem cell transplant has cured HIV infection, say doctors

#26
post #8

Earlier quoted context omitted.

I think most AIDS patients would gladly take that 10% chance.

AIDS has actually become manageable, and most HIV+ patients in the developed world die of other causes (cancer, aging, etc.) instead of AIDS. So I wouldn't be too sure.

And now HIV patients have a choice between manageable and treatable. For most of us, I think the choice would probably be obvious.

Re: Stem cell transplant has cured HIV infection, say doctors

#27
post #26

Earlier quoted context omitted.

AIDS has actually become manageable, and most HIV+ patients in the developed world die of other causes (cancer, aging, etc.) instead of AIDS. So I wouldn't be too sure.

And now HIV patients have a choice between manageable and treatable. For most of us, I think the choice would probably be obvious.

That depends on what exactly manageable means and what the risks of the cure are. The choice seems by no means obvious to me.

Here is a hypothetical example (because I don’t know much about HIV): Getting rid of frequent headaches (the hypothetical side-effect of managing a hypothetical otherwise deadly disease) with a cure that has a 1:5 chance of death doesn’t seem like a good deal to me.

Re: Stem cell transplant has cured HIV infection, say doctors

#28
post #7

If this doesn't turn out to be overblown sensationalism, then the team behind this (actual!) cure probably deserves a Nobel for their efforts and results.

It's real, but not practical. The risk of death during a transplant like this is as high as 10%, because it involves completely knocking out the immune system.

I suspect that the mortality rate would be much lower amongst patients being treated for HIV. Bone marrow transplants as a therapy for leukemia requires killing the existing cells with radiation. This is completely sensible -- you've got some cancerous cells, so nuke everything and start over from the beginning.

Confounding the mortality stats is the fact that individuals undergoing treatment are very sick from the start. We might see better survival rates amongst comparatively healthy people.

In this case, you don't necessarily need a clean slate. "All" you need is a population of cells generating HIV resistant T-cells. AIDS manifests in individuals with extremely low T-cell counts. If a population of CD4 mutants could take hold within a larger population, it might be enough to prevent AIDS and bring viral titers low enough to eliminate transmission.

Nevertheless, I agree -- it's hardly practical, but it may be a beachhead.

Re: Stem cell transplant has cured HIV infection, say doctors

#29
post #27
post #26

Earlier quoted context omitted.

And now HIV patients have a choice between manageable and treatable. For most of us, I think the choice would probably be obvious.

That depends on what exactly manageable means and what the risks of the cure are. The choice seems by no means obvious to me. Here is a hypothetical example (because I don’t know much about HIV): Getting rid of frequent headaches (the hypothetical side-effect of managing a hypothetical otherwise deadly disease) with a cure that has a 1:5 chance of death doesn’t seem like a good deal to me.

You're right. The article implies no side effects other than the strict (even aggressive, if you will) treatment regiment, which does seem somewhat fishy.

HIV may not be a death sentence anymore, but it's still a serious disease with profound implications in one's lifestyle, and as far as I'm concerned, a cure can't come soon enough.

Re: Stem cell transplant has cured HIV infection, say doctors

#30
post #20

Earlier quoted context omitted.

Good question. If you lay out your options that you know about, I'll point out if there are among them any acceptable ones in my opinion.

Based on your username are you Jewish? Because you'll be interested to know that Judaism not only permits embryonic stem cell research it actually encourages using the embryos rather than wasting them.

Nope, not Jewish. Only by stem cell. Religions are insufficient in some major ways. But they found time to include a clause about embryonic research, huh?
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