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Rose Marie Bentley lived for 99 years with organs in all the wrong places

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71–80 of 95 posts

Re: Rose Marie Bentley lived for 99 years with organs in all the wrong places

#71

How does the body figure out which side is left and which side is right? I can think of an easy way to break symmetry but it seems harder to consistently know which side is which.

Short answer: at the single cell stage there's a cilium that, spins in a single direction and establishes chirality. People with immotile cilia thus have a 50/50 chance of getting SI, because the developing body chooses randomly.

I thought it was multiple cilia, wafting fluid in a current around a cavity, a bit later than the single cell stage but still very early?

Either way, the reason a cilium spins in one direction rather than another is that the motor is a molecular machine built out of amino acids, and amino acids are themselves chiral. If you made a person out of amino acids with the opposite chirality, their cilia would go the other way, and their body would be flipped. It's a lovely example of magnifying something up from the molecular to the macroscopic.

Re: Rose Marie Bentley lived for 99 years with organs in all the wrong places

#72
post #19
post #7

This is fascinating! I was diagnosed with dextrocardia w/ situs inversus at 19. I didn't make it to 99 years old to find out I had it, but several physicians and doctors in my childhood missed the diagnosis too. Story time! This is written on mobile so I apologise for grammar and spelling errors. I had awful asthma as a child and would frequently visit hospital till my teenage years because of asthma attacks and simi…

I also have Situs Inversus Totalis. Thankfully I haven't had any major health incidents to date, and my experiences with doctors and nurses has been similar. EKGs in particular can be quite interesting. :) I'm also diagnosed with Primary Ciliary Dyskinesia, and your mention of asthma issues as a child had me wondering if it's something you're aware of? About 50% of people with PCD also have Situs Inversus Totalis. Th…

Absolutely related! The ciliary malfunction causes the situs inversus in embryonic development by swishing your chemical development signals the wrong direction

Re: Rose Marie Bentley lived for 99 years with organs in all the wrong places

#73

Earlier quoted context omitted.

> doctors look straight past the condition and consider it to be an X-ray Technician error. This can go the other way too. As a student I “corrected” an initial film as it came out the film processor. The patient hadn’t been imaged before and they had dextrocardia. Basically I turned the film over and sent it for reporting with the left and right reversed. The reporting radiologist noticed as the name tab, which used…

Did the X-ray have the metal L/R "tags" in the image? Did you assume the radiographer had placed these incorrectly? My understanding is they are how you understand orientation.

If you saw everything backwards your first assumption would be X-ray error without question. But assumptions...

Re: Rose Marie Bentley lived for 99 years with organs in all the wrong places

#74

Earlier quoted context omitted.

What's really whack when you consider it is the same neuromuscular system that allows us to walk can also be repurposed to drive a car, fly a plane and operate other machinery. Isn’t this because we purposely design all those things around our anatomy though? I’d imagine alien octopuses’ vehicles would be designed around their anatomy and they would have no trouble using them.

Not OP, but I always thought it’s amazing how it becomes second nature. You think you want to turn left and slow down, not I have to use my left foot to slowly press the brake and slowly move my hands in a circle while grasping.

> use my left foot to slowly press the brake

I'm not a driver, but isn't the left foot for the clutch? Don't you have to use both the clutch and the brake when stopping the car so the motor won't stop?

Re: Rose Marie Bentley lived for 99 years with organs in all the wrong places

#75
post #46
post #39

Earlier quoted context omitted.

Breaking with the left foot sounds really dangerous. What is the right foot doing? ...though I guess you were just reinforcing your point: driving becomes so second nature that you forget the implementation details.

People do totally drive two-footed. In a decently new car there's really no downsides, they'll stop themselves from tanking the engine if you mess up and hit both pedals.

In my experience the concern isn't the damage you cause to your car, but the confusion you give the driver behind you when your left foot resting on the break makes your break lights go on and off

Re: Rose Marie Bentley lived for 99 years with organs in all the wrong places

#76
post #7

This is fascinating! I was diagnosed with dextrocardia w/ situs inversus at 19. I didn't make it to 99 years old to find out I had it, but several physicians and doctors in my childhood missed the diagnosis too. Story time! This is written on mobile so I apologise for grammar and spelling errors. I had awful asthma as a child and would frequently visit hospital till my teenage years because of asthma attacks and simi…

You might enjoy reading "A Door in the Sand" by Roger Zelazny. (A minor spoiler) there is a scene in which the main character causes similar confusion in doctors, but in his case the reversal was caused by a mishap with a piece of alien high technology.

Re: Rose Marie Bentley lived for 99 years with organs in all the wrong places

#77

Biochemical Individuality by Roger Williams [1] is an amazing read. It discusses a wide variety of "unusual" human physiological characteristics, including bones that only occur sometimes. One hears the refrain "everyone is unique". The thing is, technically you can say "every factory made part is unique" at some level. But humans are much more unique on many more different levels, than any human-made-machine (things…

Also, maybe more in line with this news:

Freaks of Nature: What Anomalies Tell Us About Development and Evolution

https://www.amazon.com/Freaks-Nature-Anomalies-Development-E...

Re: Rose Marie Bentley lived for 99 years with organs in all the wrong places

#78

Earlier quoted context omitted.

> doctors look straight past the condition and consider it to be an X-ray Technician error. This can go the other way too. As a student I “corrected” an initial film as it came out the film processor. The patient hadn’t been imaged before and they had dextrocardia. Basically I turned the film over and sent it for reporting with the left and right reversed. The reporting radiologist noticed as the name tab, which used…

Did the X-ray have the metal L/R "tags" in the image? Did you assume the radiographer had placed these incorrectly? My understanding is they are how you understand orientation.

I can’t remember, but in a chest x-ray room it is usually taped to the Bucky reversed, in which case I had assumed the letter was around the wrong way.

Re: Rose Marie Bentley lived for 99 years with organs in all the wrong places

#79

Why is this so rare?

Given the number of people who commented here with their own stories I wonder if it actually is rare. I imagine you only find out if you're undergoing x-rays, operations and similar. If there are no obvious side-effects there could be a lot more flipped-people out there.

Doesn't almost everybody receive x-ray, ultrasonography, abdominal palpation, stethoscopy, ECG or surgery today? Does it happen often that a person grows up never ever examined by a doctor closely?

Re: Rose Marie Bentley lived for 99 years with organs in all the wrong places

#80
post #39

Earlier quoted context omitted.

Not OP, but I always thought it’s amazing how it becomes second nature. You think you want to turn left and slow down, not I have to use my left foot to slowly press the brake and slowly move my hands in a circle while grasping.

Breaking with the left foot sounds really dangerous. What is the right foot doing? ...though I guess you were just reinforcing your point: driving becomes so second nature that you forget the implementation details.

That's standard in racing.

And race drivers can drive normal vehicles too.

Of course, they are the selected elite.

I am just pointing out this is not something that should be forbidden.

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