I'm looking forward to try out Pyodide in Electron so that I can make use of all the great Python scientific and signal processing libraries for data processing.
Why wouldn't you just use regular Python?
A nice side benefit I foresee would be easier coordination of state between a JS front end and a Python process running specialized computations. The current best approach I'm aware of now involves sending data back and forth as JSON and trying to mirror what's going in Python with JS state management. The system described in this article where JS and Python can reference the same objects (and somewhat the same typing?) sounds like it could be an improvement.