I ended up being a product designer (my main, academic education), a frontend, and a backend with varying levels of expertise in my lifetime, so I have some direct experience.
My current advice as of April 2019 is to keep calm, if you can stay away from JS, do it, if you can't, pick Vue, avoid Webpack, use Typescript, and forget the rest. That should go fine for the next couple years, if you can manage to remove Webpack, even longer.