As somebody hiring more regularly now, I can sympathize. I'm usually operating on the notion that interviews are demonstrably not a very good way to select people. They are pretty random. I tend to embrace this and focus on the big picture: which is do I want to hire them.
So I have only two big topics in my head.
1) Verify that this person is competent by getting to talk about anything remotely relevant. The job here is listening; not asking. If buzzwords come up, ask follow up questions. If someone is a bull-shitter, it will show in minutes. I have some generic questions that I can put in to keep the conversation going but usually, I just focus on stuff on their CV that interests me. Tell me more. Anything. What do you want in a job? Why?
2) Establishing whether I like the person enough for further collaboration. Yes, this is super subjective. But the way this business works is that anyone passing #1 you basically should hire unless you have a good reason not to. Not liking them would be a red flag.
Most of the rest of the interview is selling them on the job and figuring out whether that even remotely aligns with their expectations. This is a sales pitch. As an interviewer, your job is getting the candidate enthusiastic about working with you. If they are good, they'll have other offers lined up. In other words, it is you the interviewer that needs to be nervous about whether they will say yes; not the other way around.
This is the most important step in the interview and this is where you either get somebody enthusiastic about working for you or disengaged. If that's the case, don't hire but if they show eagerness, interest, etc. you basically try to hire them.
It's not like we have a long list of candidates typically. So, decide quickly and act with a sense of urgency.
When I'm interviewed, I think of it as a privilege for the wannabe employer. You successfully got introduced to me by somebody I trust. We talked and I liked you somehow. Now we are talking shop. Your job is to make me want to work for you. Sell it to me. Make an effort. Don't waste my time with bullshit. I'll talk to your HR after you convince me I'm not wasting my time; not before.