51–60 of 106 posts
Earlier quoted context omitted.
I thought the same thing, but the data does not support this view. See my other comment in this thread - if you look at the symptoms of depression/anxiety rather than specific diagnoses of it, the trends are pretty clear.
If there were no data, how can you say that the data do not support this view?
Interesting review of non-drug approaches to depression and mood: - Alterations in thought (meditation) - Exposure to bright light (outdoors) - Exercise - tryptophan supplementation taken WITHOUT food for greater uptake - α-Lactalbumin found in Milk but not really a great option Definitely can speak to the exposure to light, and exercise ones. Nothing lifts my mood more than going for a run outside, in the heat of th…
100% agree - went for a bike ride yesterday for the first since September, I was beaming the entire ride. Forgot how nice it is to get outside the house and away from the computer.
Interesting review of non-drug approaches to depression and mood: - Alterations in thought (meditation) - Exposure to bright light (outdoors) - Exercise - tryptophan supplementation taken WITHOUT food for greater uptake - α-Lactalbumin found in Milk but not really a great option Definitely can speak to the exposure to light, and exercise ones. Nothing lifts my mood more than going for a run outside, in the heat of th…
Interesting review of non-drug approaches to depression and mood: - Alterations in thought (meditation) - Exposure to bright light (outdoors) - Exercise - tryptophan supplementation taken WITHOUT food for greater uptake - α-Lactalbumin found in Milk but not really a great option Definitely can speak to the exposure to light, and exercise ones. Nothing lifts my mood more than going for a run outside, in the heat of th…
Didn't read the article but surprised 5-HTP not mentioned?
Interesting review of non-drug approaches to depression and mood: - Alterations in thought (meditation) - Exposure to bright light (outdoors) - Exercise - tryptophan supplementation taken WITHOUT food for greater uptake - α-Lactalbumin found in Milk but not really a great option Definitely can speak to the exposure to light, and exercise ones. Nothing lifts my mood more than going for a run outside, in the heat of th…
> Definitely can speak to the exposure to light, and exercise ones. 100% agree - went for a bike ride yesterday for the first since September, I was beaming the entire ride. Forgot how nice it is to get outside the house and away from the computer.
The article links to an old version of the NICE guidance. The new version of that is here: https://www.nice.org.uk/guidance/cg90
It's important to note that exercise isn't being touted as a treatment for depression, but as something that may help people with sub-clinical symptoms. They have one or two symptoms of depression, but not the whole package.
> Low-intensity psychosocial interventions
> For people with persistent subthreshold depressive symptoms or mild to moderate depression, consider offering one or more of the following interventions, guided by the person's preference:
> individual guided self-help based on the principles of cognitive behavioural therapy (CBT)
> computerised cognitive behavioural therapy (CCBT)[4]
> a structured group physical activity programme.
NICE does not recommend exercise as a treatment for depression. This is because the evidence we have shows it does not work. It's not, as the author of the submitted article suggests, that we don't yet have good enough evidence.
The reasons are:
- Trp transport into CNS is rate limited by large neutral amino acid (LNAAt) transporter
- Trp has a lower affinity for LNAAt than other amino acids
- Trp, 5HTP, serotonin are strongly buffered by blood plasma proteins
So, with a high protein meal, the isoleucine, phenylalanine etc. are outcompeting typtophan at getting into the brain. With a low protein meal, insulin triggers uptake of amino acids into tissue (again, preferentially stuff that's not Trp), and Trp in blood is enriched as it dissociates from plasma proteins. Then the composition of blood amino acids is mostly Trp so it is taken up by brain tissue.
[0] https://www.ncbi.nlm.nih.gov/pubmed/22677921 [1] http://wurtmanlab.mit.edu/static/pdf/1001.pdf
People in this thread are repeating the myth that exercise is a treatment for depression, when all the evidence we have shows that it probably isn't. The article links to an old version of the NICE guidance. The new version of that is here: https://www.nice.org.uk/guidance/cg90 It's important to note that exercise isn't being touted as a treatment for depression, but as something that may help people with sub-clinica…
A) >= moderately athletic people with above average health and can sustain strenuous cardiovascular activity. For these people going out and exercising is a form of self actualization which IME is a pretty hard counter to depression. It's an "easy" way of being very good at something and that gives people some level of self worth. People on the upper end of this group are also competitive and tend to participate in teams or events that give them lots of social contact with like minded people which helps further.
B) The average non-athletic person sitting at home struggling with depression. They can try exercising and it might help but most of the time it's going to cause them to feel self conscious at the gym and worthless when they don't see any progress because they have no training or experience with how to work out (and most of the services claiming to provide such are garbage cash grabs). For these people it'll always be an uphill battle but from the point of view of people in A) they just look like they're not trying. In the end they go home feeling worse off than before because they didn't achieve anything and probably feel that it's yet another thing they can't do well or yet another failed attempt at self help. Even those that get some traction are a long way off from reaching that self actualization stage.
tl;dr exercise seems to be about maintaining a lack of depression rather than bootstrapping your way out of it.
Interesting review of non-drug approaches to depression and mood: - Alterations in thought (meditation) - Exposure to bright light (outdoors) - Exercise - tryptophan supplementation taken WITHOUT food for greater uptake - α-Lactalbumin found in Milk but not really a great option Definitely can speak to the exposure to light, and exercise ones. Nothing lifts my mood more than going for a run outside, in the heat of th…
I wonder if CBD oil raises serotonin? It seems to lift my mood for almost an entire day.
CBD is a very interesting substance. My main gripe is that, to get antidepressant and anxiolytic effects, dosages are higher than what can conveniently (and affordably) be achieved with the strength of currently available drops/flowers on the market.