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How to increase serotonin in the human brain without drugs (2007)

ncbi.nlm.nih.gov

21–30 of 106 posts

Re: How to increase serotonin in the human brain without drugs (2007)

#21
post #19

Doing my best to summarize the effects of 5-HTP and its' corresponding pubmed research: https://nutripeek.com/detail/5-htp

Do you know anything about how EGCG affects absorption of 5-HTP?

I've read in several places that 5-HTP is more effective when consumed with EGCG (green tea extract), but I'm not sure if this is just urban legend or if it has any real–world effects.

Re: How to increase serotonin in the human brain without drugs (2007)

#23

Not addressed in paper: why life is now more depressing and how to make it less depressing without brain chemical hacks

Actually, this was tangentially addressed. It specifically mentions the fact that we are getting less bright light exposure today due to our increasingly indoor habits (versus historical contexts where humans typically worked outside more), as well as the decrease in physical activity due to the changing nature of work as well. Furthermore, it specifically highlighted the disconnect between physical labor and reward (it called it "effort-based rewards"), or in very crude terms, we run to run these days, instead of running to catch our meal.

There's certainly a good deal more to the topic you brought up as a whole, but those were a couple of interesting points from the article that I thought it addressed.

Re: How to increase serotonin in the human brain without drugs (2007)

#24
post #23

Not addressed in paper: why life is now more depressing and how to make it less depressing without brain chemical hacks

Actually, this was tangentially addressed. It specifically mentions the fact that we are getting less bright light exposure today due to our increasingly indoor habits (versus historical contexts where humans typically worked outside more), as well as the decrease in physical activity due to the changing nature of work as well. Furthermore, it specifically highlighted the disconnect between physical labor and reward…

Those are reasons to want a serotonin hit, but they don't explain the huge cultural trend towards depression. Just look at 50 years ago. We were working in about the same way that we work today, in basically the same environments. Same amount of light, same lack of physical labor. How did we get more depressed in the same environment over such a short period of time?

Re: How to increase serotonin in the human brain without drugs (2007)

#25
post #9

Hardcore ravers used to pre/post-load on 5-HTP years ago.

Isn't it ironic that the article is about increasing serotonin without using a drug, and the first reflex is to suggest a drug?

I find HN is pretty strongly pro-drug and pro-supplement.

Re: How to increase serotonin in the human brain without drugs (2007)

#26
post #9

Earlier quoted context omitted.

Isn't it ironic that the article is about increasing serotonin without using a drug, and the first reflex is to suggest a drug?

It's a supplement, they're entirely different according to the FDA.

according to lobbyists

Re: How to increase serotonin in the human brain without drugs (2007)

#27
post #23

Earlier quoted context omitted.

Actually, this was tangentially addressed. It specifically mentions the fact that we are getting less bright light exposure today due to our increasingly indoor habits (versus historical contexts where humans typically worked outside more), as well as the decrease in physical activity due to the changing nature of work as well. Furthermore, it specifically highlighted the disconnect between physical labor and reward…

Those are reasons to want a serotonin hit, but they don't explain the huge cultural trend towards depression. Just look at 50 years ago. We were working in about the same way that we work today, in basically the same environments. Same amount of light, same lack of physical labor. How did we get more depressed in the same environment over such a short period of time?

It is believed that 50 years ago depression was less researched and therefore less diagnosed/recognised. Also, social stigma of mental disorders was stronger and people generally kept quiet about it. The bottom line is: it was always there, it's just that we talk about it more nowadays.

Re: How to increase serotonin in the human brain without drugs (2007)

#28
post #23

Earlier quoted context omitted.

Actually, this was tangentially addressed. It specifically mentions the fact that we are getting less bright light exposure today due to our increasingly indoor habits (versus historical contexts where humans typically worked outside more), as well as the decrease in physical activity due to the changing nature of work as well. Furthermore, it specifically highlighted the disconnect between physical labor and reward…

Those are reasons to want a serotonin hit, but they don't explain the huge cultural trend towards depression. Just look at 50 years ago. We were working in about the same way that we work today, in basically the same environments. Same amount of light, same lack of physical labor. How did we get more depressed in the same environment over such a short period of time?

For those who want more data on this [1].

[1] https://www.thecut.com/2016/03/for-80-years-young-americans-...

Re: How to increase serotonin in the human brain without drugs (2007)

#29

Earlier quoted context omitted.

Those are reasons to want a serotonin hit, but they don't explain the huge cultural trend towards depression. Just look at 50 years ago. We were working in about the same way that we work today, in basically the same environments. Same amount of light, same lack of physical labor. How did we get more depressed in the same environment over such a short period of time?

It is believed that 50 years ago depression was less researched and therefore less diagnosed/recognised. Also, social stigma of mental disorders was stronger and people generally kept quiet about it. The bottom line is: it was always there, it's just that we talk about it more nowadays.

I thought the same thing, but the data does not support this view. See my other comment in this thread - if you look at the symptoms of depression/anxiety rather than specific diagnoses of it, the trends are pretty clear.

Re: How to increase serotonin in the human brain without drugs (2007)

#30
post #22
post #5

More info on niacin/tryptophan https://www.youtube.com/watch?v=yofewUE6L-k https://www.youtube.com/watch?v=-l0S25DIxqw

I took niacin once in pill form and it made my body burst out into a fierce itch rash that lasted about an hour.

That's know as a "niacin flush" AFAIK - you might have taken too much too soon
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