Live data from Hacker News

Flashing Light, Sound Restore Memory in Alzheimer's Mice

laboratoryequipment.com

21–30 of 43 posts

Re: Flashing Light, Sound Restore Memory in Alzheimer's Mice

#21
This effect has been on here before, some people have had incredible effects with this. I've relatives who've (had) Alzheimer's, it seems worth following a "cleaning cycle" every now and again even if results aren't proven as it seems there is no evidence of harmful effects either.

Re: Flashing Light, Sound Restore Memory in Alzheimer's Mice

#22

Earlier quoted context omitted.

A lot of the binaural stuff try to set up "beats" by playing a slightly different frequency to each ear. Neither frequency is 40Hz, but the beat frequency may be. There's an absolute shedload of woo-woo stuff on the purported consciousness-enhancing benefits if you google around. That's not to say they definitely don't do funny things to your brain. https://en.wikipedia.org/wiki/Beat_(acoustics)#Binaural_beat...

> There's an absolute shedload of woo-woo stuff on the purported consciousness-enhancing benefits if you google around. Oh god, yes, and it isn't even new. Back around 2005, I ran into a web site selling audio files which they claimed would cure addictions, attract romantic partners, improve luck...

And, twenty years before that, this group claimed that binaural "synchronization" of the hemispheres of the brain could lead to out-of-body travel.

https://www.monroeinstitute.org/

I think they've backed down on some of those claims over the last 30 years, but they'll be happy to take your money for a 5 day onsite retreat.

Re: Flashing Light, Sound Restore Memory in Alzheimer's Mice

#23
post #7
post #3

>exposed laboratory mice that genetically predisposed to Alzheimer's disease to a light flickering at 40 hertz for one hour a day. They found that this treatment reduced the levels of tau and amyloid beta in visual cortex of the brain and stimulated the activity of debris-clearing immune cells. does it mean that old CRT TVs and monitors kept our Alzheimer at bay?

My old CRT monitor, an IBM 5154 clone, gave me a mild sunburn on the day I got it...

Are you sure that wasn't just from having to go outside to buy it?

Re: Flashing Light, Sound Restore Memory in Alzheimer's Mice

#25
post #5
post #3

>exposed laboratory mice that genetically predisposed to Alzheimer's disease to a light flickering at 40 hertz for one hour a day. They found that this treatment reduced the levels of tau and amyloid beta in visual cortex of the brain and stimulated the activity of debris-clearing immune cells. does it mean that old CRT TVs and monitors kept our Alzheimer at bay?

weren't fluorescent lights 40Hz?

Flourescent lights need much higher frequency. They're typically >= 22 kHz.

Re: Flashing Light, Sound Restore Memory in Alzheimer's Mice

#26
post #5
post #3

>exposed laboratory mice that genetically predisposed to Alzheimer's disease to a light flickering at 40 hertz for one hour a day. They found that this treatment reduced the levels of tau and amyloid beta in visual cortex of the brain and stimulated the activity of debris-clearing immune cells. does it mean that old CRT TVs and monitors kept our Alzheimer at bay?

weren't fluorescent lights 40Hz?

Older fluorescent lights (those run off a magnetic current limiter, or "ballast") flickered at 120Hz if they were connected to a 60Hz power source. Every time the voltage declined below a level needed to maintain a discharge, the lamp went out. That happened twice in every full sine wave of primary power.

Whether you could see the flicker depended on the phosphor luminous decay time. If the phosphors on the inside of the bulb (which glow when excited by the UV-rich plasma discharge) had a rapid luminous decay curve, you could perceive the 120Hz flicker if you scanned your eyes across a lit bulb. The afterimage on your retina was a dashed line, the dark parts being the "too little voltage" portions of the sine wave.

You can use the afterimage trick to check out duty cycle dimming of car tail and brake lights. If they're chopped slower than ~1KHz, the smeared retinal afterimage will be chopped. Don't do this if you're moving in traffic.

Re: Flashing Light, Sound Restore Memory in Alzheimer's Mice

#27
post #9

Mice clap don’t clap get clap Alzheimer’s. They have neural plaques, artificially, chemically induced, that are coincident with Alzheimer’s in humans.

I don't know why this is being downvoted as much as it is.

Wife works in a related field of neuro-sci, and regularly laments this difference, especially how it's played up in both in reporting and in assuming consistency in treatment and response. To the best of my knowledge there's not even consensus that plaques are the "root cause" we should be focusing on, so this sort of model may be multiple steps removed from applicability. (Similar problems exist even in 'more well understood' neurological systems, e.g. early vision pipeline)

It's an unfortunate but very real limitation to the current research that I think is important to understand so as to be realistic about the progress and directions of study. To be very precise, I say this as someone who, both of of scientific interest, and selfish interest (Alzheimers in my family) loves that this research is happening.

Re: Flashing Light, Sound Restore Memory in Alzheimer's Mice

#28
post #2

There was a RadioLab special on this a few years ago: https://www.wnyc.org/story/flashing-light-therapy-alzheimers...

After hearing this intriguing RadioLab episode some months back, I started searching around youtube for 40 Hz tones and found quite a lot of videos of all kinds that use those and other tones allegedly related to various brain waves (Alpha, Beta, Gamma, etc). I listened to a whole bunch of these videos, and while I wasn't measuring my memory, I did pay close attention to how the sounds made me feel, and this one part…

That first video definitely is giving me a strange sensation too, it's like my ears and nose are vibrating in response to the "beats" of the audio.

Re: Flashing Light, Sound Restore Memory in Alzheimer's Mice

#29
post #5

Earlier quoted context omitted.

weren't fluorescent lights 40Hz?

Older fluorescent lights (those run off a magnetic current limiter, or "ballast") flickered at 120Hz if they were connected to a 60Hz power source. Every time the voltage declined below a level needed to maintain a discharge, the lamp went out. That happened twice in every full sine wave of primary power. Whether you could see the flicker depended on the phosphor luminous decay time. If the phosphors on the inside of…

Yep! I do this in traffic when bored...not when moving tho, just sitting in stop and go traffic. Its interesting to see the different patterns, doesn't seem to be much consistency to the pulse width they have.

Re: Flashing Light, Sound Restore Memory in Alzheimer's Mice

#30

If you feel like bad science and poorly supported practices are up your alley, I build a Chrome extension to flash an overlay on your browser at specifiable frequencies: https://chrome.google.com/webstore/detail/gammaloid/lfmaoakh...

You may want to justify why it is "bad science" and write a letter to the editor of Nature and Nature Protocols. Is the media interpretation of these studies misguided? Sure, but the popular science media is not doing the science.

I would be peeved if people called my research "bad science" because some pop. sci. article doesn't understand it.

Post reply on HN