111–120 of 132 posts
I take Natrol brand Melatonin Fast Dissolve Tablets, Strawberry flavor, 3mg, splitting them in half (for 1.5 mg) and put it under my tongue for sublingual absorption.
Question for people on melatonin. I tried 0.5 mg does, from cutting a 1 mg pill in half. Didn't have much effect. Had a concussion three months ago and started taking 2 mg based on a post concussion study I read. this did markedly improve my sleep. 1. Did anyone experience a good effect only at higher doses 2. I'm doing much better day to day on this dosage, but I don't want to impair my own production. Do I need to…
For anyone taking Melatonin as a sleeping aid: The dosages it is being sold at are way too high. Recent studies point to 0.3 mg being the right amount for adults [1]. That dosage (taken over a period of several months every day at the same time) helped me get through a period of insomnia last summer, when basically all the other medications failed or had too strong side effects. [1] http://news.mit.edu/2001/melatonin…
I recall listening to a sleep specialist on a radio show one morning (how's that for citing my sources). Apparently there are two different methodologies for administering Melatonin. One is to use a higher dose(1mg - 3mg) before sleep (~an hour) as a hypnotic. The other is to take a much lower dose, closer to the 0.3mg you suggested, roughly 4 - 6 hours before the desired bed time. The latter is used for modifying th…
I once asked about melatonin in a health food shop and was told it’s illegal in the UK! The seems odd in a country where (for example) you can buy codeine pills over-the-counter, so now I’m curious about why it was banned, considering it’s reported to have few side effects?
The cynical answer is that sleep medications (and I mean the more highly scheduled varieties) are among the biggest pharmacological money spinners. Melatonin is cheap and unpatentable (although there was several attempts at melatonin mimetics, e.g. agomelatine). It's unfathomable that melatonin is available only on prescription (and has become increasingly hard to obtain). I think the toxicity is close to water... on…
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Free radical damage is not the main mechanism of UV-induced DNA damage. The main mechanism is direct dimerization as the photo-excited electron relaxes. https://en.wikipedia.org/wiki/Direct_DNA_damage
It's hard to see how anything could prevent that other than sunscreen.
Melanin, the body’s main pigment, turns UV light into heat inside the cells, but outside the nucleus. (The melanin is gathered into a shield-like collection of “melanosomes” which is “above” the nucleus relative to the outside of the body—like this: https://skincancer909.com/wp-content/uploads/2017/03/4K-sunh...) This has the same effect: the UV light never hits the DNA, and so never causes DNA damage.
Melatonin is known to recruit, or cause the production of, melanin within melanosomes. I’m not sure if this is the dynamic being discussed by the paper, though, or whether melatonin is more directly able to act in a similar capacity to melatonin exogenously. If it can, then the same explanation applies. (Does anyone know if pure melatonin powder looks black under a UV filter? That’d suggest it could act directly like melanin, despite its dissimilar chemical structure.)
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Have you tried trazadone or mirtapine? I've had good results with trazadone, bu would wake up after 5-6 hours with adolescent-like erections and read that it can actually cause priapism; mirtazapine works wonderfully(also a very strong antihistamine at lower dosages) but it leaves me groggy for 24 hours.
On the subject of mirtazapine, I was like a zombie for the first week @15mg and ready to ditch it but the doc persuaded me to stick it out and sure enough the chronic drowsiness went away by the following week, leaving only the potent sleep induction that encouraged an increase to 30mg. But this thread terrifies me now, finding it's also a dementia-inducer. Is there any literature I can review to either allay or just…
It's also a pity because I used to feel quite well rested and clear headed the day after antihistamines.
I've been taking melatonin for the last 3 months since cutting out alcohol and it seemed to help with falling into a sleep. As Friday I stopped taking it because I don't want to be reliant on something for sleep other than exercise and proper diet. Anecdotally, my sleep the last three nights since cutting it out have been horribly restless and not fulfilling. I'd rather not take it but if after a week normal sleep do…
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I didn't read the paper since it first came out (1-2 years ago?), but I seem to recall a clear causal link was found?
I would really encourage you to review the study again. For example, the authors themselves acknowledged a lot of legitimate reader concerns with the inclusion of this statement: "These observational studies have 4 important limitations. First, current anticholinergic use was ascertained at study entry and periodically during follow-up only by conducting a medication inventory. Second, these studies lacked informatio…
Earlier quoted context omitted.
The cynical answer is that sleep medications (and I mean the more highly scheduled varieties) are among the biggest pharmacological money spinners. Melatonin is cheap and unpatentable (although there was several attempts at melatonin mimetics, e.g. agomelatine). It's unfathomable that melatonin is available only on prescription (and has become increasingly hard to obtain). I think the toxicity is close to water... on…
Weird, where are you that Melatonin is prescription only and difficult to obtain? I Can get it at any drug and grocery store I walk into in a variety of doses.
