71–80 of 132 posts
That dosage (taken over a period of several months every day at the same time) helped me get through a period of insomnia last summer, when basically all the other medications failed or had too strong side effects.
> administering melatonin prior to exposure to UV radiation increases cell survival and reduces oxidative damage. Topical melatonin applied to skin 15 minutes prior to exposure to UV radiation completely prevented skin redness (erythema) in a small randomized double-blind study of human subjects This isn't necessarily good news. Sun burn is your body's way of reducing skin cancer. When your body detects too much expo…
Are you saying this as a medical research professional or just spitballing? Because the article send to be straightforwardly claiming that melatonin is reducing oxidative damage, not just disabling the visible effects. One of the referenced sources is entitled, "Melatonin as a major skin protectant: from free radical scavenging to DNA damage repair," which seems to be saying that the "more research needed" has alread…
Earlier quoted context omitted.
Melatonin works mildly well for me for a few days, but quickly stops working again, which is unfortunate. I will admit I also have some anxiety issues I need to work on. For better or worse, a low dose of diphenhydramine hcl (12mg) has continued working for me for over a decade without needing to up the dose. My personal experience as far as habit forming goes: I only take it on work nights, and sleep just fine on we…
The problem with is diphenhydramine is the increased Alzheimer's risk: https://www.health.harvard.edu/blog/common-anticholinergic-d...
Taking it every day for years though is probably not a good idea.
For anyone taking Melatonin as a sleeping aid: The dosages it is being sold at are way too high. Recent studies point to 0.3 mg being the right amount for adults [1]. That dosage (taken over a period of several months every day at the same time) helped me get through a period of insomnia last summer, when basically all the other medications failed or had too strong side effects. [1] http://news.mit.edu/2001/melatonin…
Tangentially I'm interested to know whether taking melatonin for long periods of time (years) reduces its effectiveness. I've been taking it for nearly a year but I've heard stories about how you need to keep increasing the dose to get the same effect.
Indeed melatonin supplementation causes tolerance development. The correct dose to avoid it is 0.3 mg [1]. Nevertheless I'm glad pharmacies sell pills with much higher dosage - you can just buy the 2-10mg pills, crush them and take the dose you need. I bet they would sell 0.3 mg pills for the same high price if they knew. [1] https://slatestarcodex.com/2018/07/10/melatonin-much-more-th...
I once asked about melatonin in a health food shop and was told it’s illegal in the UK! The seems odd in a country where (for example) you can buy codeine pills over-the-counter, so now I’m curious about why it was banned, considering it’s reported to have few side effects?
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“Any” seems incredibly implausible. Class A drugs have penalties for mere possession.
Drugs as those which are controlled under the Medicines Act not by the Misuse of Drugs Act. There is no limit on importing POM for self use, the violation only happens if you distribute them without a prescription.
I once asked about melatonin in a health food shop and was told it’s illegal in the UK! The seems odd in a country where (for example) you can buy codeine pills over-the-counter, so now I’m curious about why it was banned, considering it’s reported to have few side effects?
For anyone taking Melatonin as a sleeping aid: The dosages it is being sold at are way too high. Recent studies point to 0.3 mg being the right amount for adults [1]. That dosage (taken over a period of several months every day at the same time) helped me get through a period of insomnia last summer, when basically all the other medications failed or had too strong side effects. [1] http://news.mit.edu/2001/melatonin…