41–50 of 132 posts
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Nothing is bad in melatonin except the tolerance development. If I wasn't afraid of developing tolerance to endogenous melatonin I would take huge doses of it every evening.
So you're saying it's pretty much a free lunch?
I know a lot of people who take melatonin to fall asleep. Trying to understand if that's good or bad here?
>Melatonin administration has been found to increase hair growth in a variety of mammals >In a randomized double-blind study of 40 women with hair loss, melatonin solution applied to the scalp increased hair growth significantly relative to placebo Seems like a positive. The article is suggesting that by helping regulate the circadian rhythm, the use of melatonin can potentially: extend lifespan, prolong fertility, r…
Source?
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The problem with is diphenhydramine is the increased Alzheimer's risk: https://www.health.harvard.edu/blog/common-anticholinergic-d...
Well that's concerning. I brought up long-term use to my GP, and didn't seem too concerned, but asked me to switch to melatonin, which I tried for a while. These studies are extremely difficult to make an informed decision on, thanks to nearly everything being "linked" to some disease. See: Red meat [1] I need to wean off it though. Thankfully dementia doesn't run in my family. https://www.iarc.fr/wp-content/uploads/…
Tangentially I'm interested to know whether taking melatonin for long periods of time (years) reduces its effectiveness. I've been taking it for nearly a year but I've heard stories about how you need to keep increasing the dose to get the same effect.
Still works wonders
Tangentially I'm interested to know whether taking melatonin for long periods of time (years) reduces its effectiveness. I've been taking it for nearly a year but I've heard stories about how you need to keep increasing the dose to get the same effect.
I have chronic insomnia, I had it all my life. I used to use melatonin but yes over time it lost its effect and melatonin is not one of those drugs you can just take more to sleep. It has a very precise dosage and if you take more it doesn't make you more sleepy. If you have chronic insomnia, you need to solve the root cause. In my case it is anxiety, and currently I'm trying to solve my anxiety and my sleep quality…
Curious if you've tried that?
The seems odd in a country where (for example) you can buy codeine pills over-the-counter, so now I’m curious about why it was banned, considering it’s reported to have few side effects?
I once asked about melatonin in a health food shop and was told it’s illegal in the UK! The seems odd in a country where (for example) you can buy codeine pills over-the-counter, so now I’m curious about why it was banned, considering it’s reported to have few side effects?
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Doxylamine succinate is a potent anticholinergic drug, as are (IIRC) all other OTC antihistamines that cause drowsiness. Long term use of such drugs have been linked to dementia later in life. I would at least read some of the literature and re-evaluate whether using drugs like this to sleep on a regular basis is worthwhile.
Something that I have not been able to get an answer to; could the long-term effects of regular antihistamine use be mitigated by supplementing with choline in the morning/daytime?
Tangentially I'm interested to know whether taking melatonin for long periods of time (years) reduces its effectiveness. I've been taking it for nearly a year but I've heard stories about how you need to keep increasing the dose to get the same effect.
Anectdotal: daily use of 3 mg every night for three years Still works wonders
I once asked about melatonin in a health food shop and was told it’s illegal in the UK! The seems odd in a country where (for example) you can buy codeine pills over-the-counter, so now I’m curious about why it was banned, considering it’s reported to have few side effects?
That said you can import them from outside of the UK since you can import any drug for personal use even without prescription.