That's what Zipline uses for their fully operational medical delivery system in Rwanda.
The drones are completely blind, directly, but they travel in pre-defined flight paths and communicate with one another and follow directions from flight control.
For self-driving cars, a similar situation may be extremely good GPS geolocation combined with network-wide sensor fusion and mapping. In principle, you could even do real-time optical or synthetic aperture radar from orbit or via persistent aircraft to allow the central controller to identify hazards and obstacles and to update maps in real time without much at all happening on-board except low-latency reactions. Most highways already have much of their length covered by cameras for the local Department of Transportation, and even many intersections and sidestreets have surveillance cameras. A low latency connection to that system, upgraded with higher fidelity, could significantly help autonomous systems. Might be another very helpful public good for cities to provide, much like GPS is provided.
...and on the engineering side, you can have vehicles designed specifically to reduce pedestrian injury, such as not having those large, boxy grilles on SUV. Such things are almost entirely cosmetic and reduce efficiency, so Tesla doesn't have them on their cars. Going beyond that, external airbags may help as well. Zipline uses a foam body and a fail-safe parachute to stop the vehicle if there's a problem.