Uranium ore is mostly alpha particle radiation. Clothing and aluminum foil are generally sufficient to block alpha particle radiation. Uranium metal can be up 28% beta particle, which can be blocked by sandbags or a thick brick wall. Depleted uranium contains almost no beta particle radiation. Uranium ore lacks the purity of uranium metal and usually more beta particles than depleted unranium but not much more though it’s purity and composition are naturally variant.
Because of that uranium is radioactive and that radioactivity is harmful, but is not the primary harm, unless you are allergic to uranium at which point the radiation is the primary harm. Also, sensitivity to radiation varies wildly by person. Uranium is a high density metal that has some dissolution capability into water, like lead, which means heavy metal poisoning. Uranium is more dense than lead and thus more poisonous but less poisonous than osmium. Under certain conditions uranium can be (or become) very brittle and break apart into a fine dust that can be respirated.