Earlier quoted context omitted.
Only because the mass to energy conversion is 100%. But, if you factored in the size of whatever object you use to contain the antimatter, then your mass to energy conversion is probably comparable to a hydrogen bomb. Further, factor in the the energy required to contain the antimatter and it seems like it's losing proposition, probably until you start to approach the size of a small house or larger. So then the argu…
The "object you use to contain the antimatter" is not very large, it can be wheeled around in a lab. The "energy required to contain the antimatter" is not very significant, liquid helium cooled inside a liquid nitrogen shell, and some rather ordinary (in terms of power usage) electric and magnetic fields. 100 grams of antimatter has a yield similar to a 4 megaton hydrogen bomb.
Also, assuming it is positrons, I'd imagine you might also have to worry slightly about relativistic background electrons and gamma rays/pair production, unless you're under 10ft+ of concrete. The extremely rare case that a 10^19 eV cosmic ray hits you head on sounds like an awesome way to possibly produce a spontaneous "detonation", or when some jokester thinks it's awesome to point a LINAC right at you.