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Microbiome interactions shape host fitness

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Re: Microbiome interactions shape host fitness

#21

Post by dpatrick86 »

andy_ppp wrote: post #2

I was trying to research the best probiotic to start taking (for humans not fruit flies) and I became totally bewildered... any recommendations or research from hacker news welcome!

VSL#3 is one that has a lot of clinical research (search Google Scholar or PubMed). The catch is that the company producing VSL#3 no longer uses the formula that historically was used in the vast array of clinical research conducted. Whether some of the changes matter is up for debate. However, the original formulation is now sold under brand name Visbiome.

https://www.visbiome.com/blogs/news/maryland-federal-jury-un...

Re: Microbiome interactions shape host fitness

#22

Post by mitchtbaum »

SmellyGeekBoy wrote: post #13
andy_ppp wrote: post #2

I was trying to research the best probiotic to start taking (for humans not fruit flies) and I became totally bewildered... any recommendations or research from hacker news welcome!

I'd have thought that trying to eat a varied and balanced diet most of the time would be more beneficial to your gut microbiome than constantly artificially topping it up. The fact that people need to keep taking these things daily is evidence that they're not creating any kind of sustainable culture in there.

I believe that's the benefit. They're symbiotes of a healthy environment. They enter, do something good, then leave. The one's that enter and wish to stay are the ones we don't want in us.

Re: Microbiome interactions shape host fitness

#23

Post by mrob »

ImaCake wrote: post #10
andy_ppp wrote: post #2

I was trying to research the best probiotic to start taking (for humans not fruit flies) and I became totally bewildered... any recommendations or research from hacker news welcome!

Pick one with a long list of lactobacilli. Probably the most important thing you can do for your microbiome is eat enough fibre. Eats some beans and some carrots. Cut back on the high fructose corn syrup and save antibiotics as a last resort.

IMO, the easiest way to eat more vegetables is to buy them frozen. Frozen vegetables are cheaper than fresh, sold pre-chopped, and often nutritionally better because freezing stops the decay of vitamins. You can buy them without planning ahead and not worry about them rotting. Assuming you have access to a freezer, the only disadvantage is the softer texture. I eat more vegetables than most people I know, but I spend less time preparing them. I think the inconvenience of fresh vegetables discourages a lot of people from eating them, but frozen vegetables can solve the problem.

Re: Microbiome interactions shape host fitness

#24

Post by amelius »

andy_ppp wrote: post #2

I was trying to research the best probiotic to start taking (for humans not fruit flies) and I became totally bewildered... any recommendations or research from hacker news welcome!

Anecdote: some time ago I used a little bit of 3% peroxide for a while for a sore tooth, recommended by my dentist. I did not swallow the solution (well, probably a little bit by accident). Surprisingly, during that time, not only did my tooth get better, but also my stool improved quite a bit. And now I find this: [1]. I'm not sure what to make of it, but there might be something to it.

[1] https://sciencetrends.com/restoring-gut-health-the-benefits-...

Re: Microbiome interactions shape host fitness

#25

Post by notabee »

andy_ppp wrote: post #2

I was trying to research the best probiotic to start taking (for humans not fruit flies) and I became totally bewildered... any recommendations or research from hacker news welcome!

First off, there is no "best" probiotic. The very best thing for your guts is an extremely diverse set of commensal bacteria that have adapted to cooperate with the human body, preferably inherited from your family down many generations. Hardly anyone has that any more, thanks to generations of antibiotics and diet lacking a variety of fiber.

Probiotics are like a mercenary army that you can bring in when some pathogens are causing havoc or the equilibrium is very disturbed. They generally don't stick around permanently but they help outcompete the nasty microbes. Unfortunately, they also compete with the good microbes in many cases (the "standing army").

We really don't have a good process to restore the species that get lost through antibiotics and bad diet other than good diet for a long period of time (a wide and balanced variety of whole plant fiber) hoping the good bacteria will establish themselves again, or a fecal transplant which has all the risks of a blood transfusion if the donor isn't screened thoroughly.

Re: Microbiome interactions shape host fitness

#26

Post by athenot »

andy_ppp wrote: post #2

I was trying to research the best probiotic to start taking (for humans not fruit flies) and I became totally bewildered... any recommendations or research from hacker news welcome!

We try to solve things with pills, and certainly that is a very useful delivery mechanism for active medications. But there are a lot of fermented foods out there that have become unfamiliar in the Standard American Diet.

The current science is still unclear about which bacteria combo is important, in which proportions, in which part of the GI system. BUT we do know gut flora is important.

So my approach is to consume (in moderation but regularly) a variety of fermented foods that come from traditional cuisines. Yogurt with a wide variety of active cultures, Miso, Cheese from unpasteurised milk, Kimchi, etc.

Also raw vegetables will likely have traces of microbes from the soil they were grown in, though I have no idea what role those play, if any.

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