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New pill can deliver insulin

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Re: New pill can deliver insulin

#81

Post by ghostbrainalpha »

daeken wrote: post #26
RPLong wrote: post #16

Earlier quoted context omitted.

What doctors and researchers get wrong about diabetes is that pin-pricks and injections are not even remotely bad. I don't know a single diabetic who cares about injections and blood sugar tests. You get used to that within the first week of diagnosis. No, the unpleasant part of being diabetic is having to live every second of your life as an act of weighing how what you're currently doing is going to affect your blo…

> I don't know a single diabetic who cares about injections and blood sugar tests. I'm diabetic and the sole reason I don't check my blood sugar (unless I think something is drastically out of whack) is that it takes me upwards of 30 minutes to do a finger prick for testing. My anxiety skyrockets and nothing I do can tell me that it's not going to be excruciating. Most of the time I end up having my wife do it, which…

I also have a needle aversion. A couple things that helped me.

1) Playing the guitar helped me build calluses big enough that I can't feel my finger tips anymore on my left hand.

2) I like to put an ice cube on the skin about an inch away from where I give himself a shot in my stomach. For me my brain really focused on the cold sensation from the ice and I notice the needle much less. It's nice too because the ice melts a little and I can use that water on the skin to wipe away any blood that drip out after the injection.

Re: New pill can deliver insulin

#82

Post by 1123581321 »

RPLong wrote: post #16
samcday wrote: post #4

> Once ingested, water dissolves a disk of sugar, using a spring to release a tiny needle made up almost entirely of freeze-dried insulin. The needle is injected into the stomach — which the patient can’t feel, owing to a lack of pain receptors in the stomach. Once the injection has occurred, the needle can break down in the digestive tract. That's some pretty impressive ingenuity. Also sounds kinda terrifying if the…

What doctors and researchers get wrong about diabetes is that pin-pricks and injections are not even remotely bad. I don't know a single diabetic who cares about injections and blood sugar tests. You get used to that within the first week of diagnosis. No, the unpleasant part of being diabetic is having to live every second of your life as an act of weighing how what you're currently doing is going to affect your blo…

I am type 1.5 and disagree with both parts of your post. While learning to use them routinely only takes a few days, needles and lancets do bother people for anxiety reasons, but also for physiological reasons. Lancet areas develop callouses, can have blood flow issues and in more advanced stages of diabetics can risk infections/damage. Injection sites go bad over time or appear to; right now I am dealing with an issue where I think some of my preferred injection sites are becoming less effective, but I can’t really tell, which is preoccupying. I don’t think research into alleviating the need to use needles and lancets is getting anything wrong just because it solves a need not every diabetic has.

Secondly, I think your description of diabetes is overblown. If you’re checking BGL frequently with a CGM, then you have a good understanding of what will happen in routine situations. If you’re not, you aren’t going to sweat 30 minutes in the car or the delta between the carbs from dinner plus toast and physical activity (I do like the humble-brag here, though!) because you don’t know what’s going on anyway. Hypoglycemia has the advantage of being treated with glucose tablets, which don’t spoil and can be stashed everywhere. Moderate activity and water intake are important but not going to swing your BGL wildly like a bottle of soda or an intense workout.

This disease can be a hypochondriac’s dream and I think that teaching other diabetics to be so preoccupied is dangerous to them because it increases the temptation to give up on the daily routines that actually make a difference.

Re: New pill can deliver insulin

#83

Post by Nasrudith »

phkahler wrote: post #62
Pharmakon wrote: post #29

Earlier quoted context omitted.

Once ingested, water dissolves a disk of sugar, using a spring to release a tiny needle made up almost entirely of freeze-dried insulin. The needle is injected into the stomach — which the patient can’t feel, owing to a lack of pain receptors in the stomach. Once the injection has occurred, the needle can break down in the digestive tract. With the right compound in the needle, thst sounds like an incredible way to a…

>> With the right compound in the needle, thst sounds like an incredible way to assassinate someone without leaving any traces which are unlikely to be found. If I recall correctly there was a story about a CIA weapon that shot a needle or dart made of a frozen toxin. It would penetrate the skin, melt, and cause a heart attack. There would be no evidence other than an incredibly hard to find hole in the skin with no…

I don't think that myth would work out although it is a common one. Namely it would show up on a tox screen in some way presumably. Since that is usually how poisonings are found - granted they would need to do an autopsy in the first place.

Re: New pill can deliver insulin

#84

Post by danhon »

visava wrote: post #67

Plant based diet can reverse diabetes ( I and II ). For type I milk products need to be stopped. Take 1% of your bodyweight as fruits. Take 1 % of your body weight as Raw ( uncooked ) vegetables. Take 10% of that vegetable quota as green leafy vegetables. Based on China Study by Colin Campbell. e.g. weight 150 pounds 1.5 pounds fruits before 1 pm 1.5 pounds raw vegetables for the day If you are still hungry you can e…

T1 can’t be reversed.

Re: New pill can deliver insulin

#85

Post by lolc »

visava wrote: post #67

Plant based diet can reverse diabetes ( I and II ). For type I milk products need to be stopped. Take 1% of your bodyweight as fruits. Take 1 % of your body weight as Raw ( uncooked ) vegetables. Take 10% of that vegetable quota as green leafy vegetables. Based on China Study by Colin Campbell. e.g. weight 150 pounds 1.5 pounds fruits before 1 pm 1.5 pounds raw vegetables for the day If you are still hungry you can e…

You mean diabetes type 2.

It's tiring to keep getting suggestions of how to change diet when my body absolutely needs insulin from an external source. Further, while people may be able to reverse type 2, they still need insulin until they actually get there. So research into insulin delivery is relevant to all diabetics.

Also there are many ways of reducing carbohydrate intake. The diet you write about is just one of many ways to do that. Why single it out?

Re: New pill can deliver insulin

#86

Post by RPLong »

ricardobeat wrote: post #69
RPLong wrote: post #21

Inhalable insulin was a total failure, even though it worked. I don't expect this to succeed where inhalable insulin failed.

Mannkind is still around, though not growing much. Why do you think it was a total failure?

Oh, really? I thought I read an article about how the product had been discontinued. I stand corrected.

Re: New pill can deliver insulin

#87

Post by snowmaker »

_uhtu wrote: post #78
arkades wrote: post #41

If this is at all attractive to people, it's going to make insulin so damned expensive. The price of insulin is already rising: there aren't all that many generic manufacturers of it, leaving them in a competition-free market. If this takes off it's going to suck up a good chunk of the marketplace, and probably leave us with maybe one or two generic manufacturers - enough to have an effective monopoly. Insulin prices…

Manufacturing insulin isn't under patent or a trade secret is it? If the price of insulin rises, then manufacturing insulin becomes more economically viable, so new players will enter the arena, thus driving the price down. Is there any reason this wouldn't be subject to the normal laws of supply and demand?

You would think so, but the market is dysfunctional because of the regulatory complexity of the US healthcare system: https://health.usnews.com/health-care/for-better/articles/20...

Re: New pill can deliver insulin

#88

Post by BurningFrog »

Pharmakon wrote: post #29
samcday wrote: post #4

> Once ingested, water dissolves a disk of sugar, using a spring to release a tiny needle made up almost entirely of freeze-dried insulin. The needle is injected into the stomach — which the patient can’t feel, owing to a lack of pain receptors in the stomach. Once the injection has occurred, the needle can break down in the digestive tract. That's some pretty impressive ingenuity. Also sounds kinda terrifying if the…

Once ingested, water dissolves a disk of sugar, using a spring to release a tiny needle made up almost entirely of freeze-dried insulin. The needle is injected into the stomach — which the patient can’t feel, owing to a lack of pain receptors in the stomach. Once the injection has occurred, the needle can break down in the digestive tract. With the right compound in the needle, thst sounds like an incredible way to a…

Perhaps this is a "peace dividend" of a military project, much like the Hubble Telescope.

Re: New pill can deliver insulin

#89

Post by visava »

danhon wrote: post #84
visava wrote: post #67

Plant based diet can reverse diabetes ( I and II ). For type I milk products need to be stopped. Take 1% of your bodyweight as fruits. Take 1 % of your body weight as Raw ( uncooked ) vegetables. Take 10% of that vegetable quota as green leafy vegetables. Based on China Study by Colin Campbell. e.g. weight 150 pounds 1.5 pounds fruits before 1 pm 1.5 pounds raw vegetables for the day If you are still hungry you can e…

T1 can’t be reversed.

This diet with stopping milk products can. Milk protein with 17 rings similar to beta cells. Body in an attempt to kill milk protein which escapes into blood without breaking down the ring structure also kills beta cells https://www.youtube.com/watch?v=4edofibXOiM watch at 48 mins

Re: New pill can deliver insulin

#90

Post by Qwertystop »

_uhtu wrote: post #78
arkades wrote: post #41

If this is at all attractive to people, it's going to make insulin so damned expensive. The price of insulin is already rising: there aren't all that many generic manufacturers of it, leaving them in a competition-free market. If this takes off it's going to suck up a good chunk of the marketplace, and probably leave us with maybe one or two generic manufacturers - enough to have an effective monopoly. Insulin prices…

Manufacturing insulin isn't under patent or a trade secret is it? If the price of insulin rises, then manufacturing insulin becomes more economically viable, so new players will enter the arena, thus driving the price down. Is there any reason this wouldn't be subject to the normal laws of supply and demand?

https://www.cbsnews.com/news/how-drug-companies-keep-insulin...

Looks like a patent issue (every new improvement in production methods has its own patent, so the insulins for which patents have expired are lower-quality in one way or another) plus shipping costs (refrigerated bottled liquids with a shelf life <6 months).

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