Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

New pill can deliver insulin

news.mit.edu

Post reply on HN
Print view View original

61–70 of 260 posts

Re: New pill can deliver insulin

#61

Post by sodosopa »

daeken wrote: post #26
RPLong wrote: post #16

Earlier quoted context omitted.

What doctors and researchers get wrong about diabetes is that pin-pricks and injections are not even remotely bad. I don't know a single diabetic who cares about injections and blood sugar tests. You get used to that within the first week of diagnosis. No, the unpleasant part of being diabetic is having to live every second of your life as an act of weighing how what you're currently doing is going to affect your blo…

> I don't know a single diabetic who cares about injections and blood sugar tests. I'm diabetic and the sole reason I don't check my blood sugar (unless I think something is drastically out of whack) is that it takes me upwards of 30 minutes to do a finger prick for testing. My anxiety skyrockets and nothing I do can tell me that it's not going to be excruciating. Most of the time I end up having my wife do it, which…

I have a strong aversion to needles but I’ve been a type 1 diabetic for many years. I use an older Medtronic pump and want to move to a CGM soon

My checks take about 5-10 seconds but I can see where after a while it can make you hesitant.

Re: New pill can deliver insulin

#62

Post by phkahler »

Pharmakon wrote: post #29
samcday wrote: post #4

> Once ingested, water dissolves a disk of sugar, using a spring to release a tiny needle made up almost entirely of freeze-dried insulin. The needle is injected into the stomach — which the patient can’t feel, owing to a lack of pain receptors in the stomach. Once the injection has occurred, the needle can break down in the digestive tract. That's some pretty impressive ingenuity. Also sounds kinda terrifying if the…

Once ingested, water dissolves a disk of sugar, using a spring to release a tiny needle made up almost entirely of freeze-dried insulin. The needle is injected into the stomach — which the patient can’t feel, owing to a lack of pain receptors in the stomach. Once the injection has occurred, the needle can break down in the digestive tract. With the right compound in the needle, thst sounds like an incredible way to a…

>> With the right compound in the needle, thst sounds like an incredible way to assassinate someone without leaving any traces which are unlikely to be found.

If I recall correctly there was a story about a CIA weapon that shot a needle or dart made of a frozen toxin. It would penetrate the skin, melt, and cause a heart attack. There would be no evidence other than an incredibly hard to find hole in the skin with no physical object to be found.

Re: New pill can deliver insulin

#63

Post by amelius »

m3kw9 wrote: post #59

I’m hoping Apple will pull out a miracle and able to measure blood sugar with the Apple Watch. With that data, people can make apps to do really cool things to help that person out.

Apple's focus is on "average" people, not people with diabetes.

Also it saddens me to hear "I hope that company X will solve Y" instead of "I hope some university develops a method to solve Y".

Re: New pill can deliver insulin

#64

Post by phkahler »

throwitaway6512 wrote: post #8
sithlord wrote: post #3

Study by Novo Nordisk. one of the fine companies responsible for raising insulin prices by thousands of percent.

Read up on the matter. The culprits are pharmacy benefits managers who push producers to increase list prices while demanding obscene rebates that are never passed on to the consumers. Most producers don’t disclaim the rebates, but Lars Fruegaard (Novos CEO) is on record saying that it increased from 64% to 67% last year. So pharmacy benefits managers are pushing up the list price but less and less is getting through…

Can they just sell direct to consumers? Cut out the pharmacy and the insurance companies. You guys could earn more while the patient pays less.

Re: New pill can deliver insulin

#65

Post by jayalpha »

m3kw9 wrote: post #59

I’m hoping Apple will pull out a miracle and able to measure blood sugar with the Apple Watch. With that data, people can make apps to do really cool things to help that person out.

I doubt that the apple watch will be able to do this reliably.

But if someone is interested (speak investment interested) in non-invasive blood glucose measurement feel free to inquire. Peer reviewed publications available.

Re: New pill can deliver insulin

#66

Post by taternuts »

helsinki wrote: post #22
RPLong wrote: post #16

Earlier quoted context omitted.

What doctors and researchers get wrong about diabetes is that pin-pricks and injections are not even remotely bad. I don't know a single diabetic who cares about injections and blood sugar tests. You get used to that within the first week of diagnosis. No, the unpleasant part of being diabetic is having to live every second of your life as an act of weighing how what you're currently doing is going to affect your blo…

T1 here. This is a perfect summary. I received my Dexcom G6 yesterday. If you dont have a CGM and insulin pump, I highly recommend both.

My friend is T1 and uses a Dexcom as well, it seems like a way better solution. He recently got a diabetic alert dog too which seemed to give him a lot more piece of mind, although I realize that's a pretty expensive route and not for everyone.

Re: New pill can deliver insulin

#67

Post by visava »

Plant based diet can reverse diabetes ( I and II ). For type I milk products need to be stopped. Take 1% of your bodyweight as fruits. Take 1 % of your body weight as Raw ( uncooked ) vegetables. Take 10% of that vegetable quota as green leafy vegetables. Based on China Study by Colin Campbell.

e.g. weight 150 pounds 1.5 pounds fruits before 1 pm 1.5 pounds raw vegetables for the day If you are still hungry you can eat cooked food after completing daily raw fruits vegetable quota. Avoid all animal,milk,processed packaged products and heated oils. Will reverse diabetes in 3 days for newly detected patients. Add 1 day for each year you have diabetes

https://biswaroop.com/ https://www.youtube.com/watch?v=KgxvGu4fuGo&t=561s lookup his youtube videos

Re: New pill can deliver insulin

#68

Post by ymolodtsov »

amelius wrote: post #63
m3kw9 wrote: post #59

I’m hoping Apple will pull out a miracle and able to measure blood sugar with the Apple Watch. With that data, people can make apps to do really cool things to help that person out.

Apple's focus is on "average" people, not people with diabetes. Also it saddens me to hear "I hope that company X will solve Y" instead of "I hope some university develops a method to solve Y".

Diabetes is becoming more and more common, especially in the US. It also could be used for monitoring healthy people so they don’t fall into T2 diabetes. The problem is, at the current technology level it might not be possible. Johnson&Johnson tried to do that for decades and failed.

Re: New pill can deliver insulin

#70

Post by tokai »

cazum wrote: post #42
RPLong wrote: post #28

Earlier quoted context omitted.

I'm saying Novo Nordisk produces insulin, and in doing so causes downward pressure on insulin prices thanks to basic economics. (When the supply of a good increases at the same level of demand, price falls.) This is true for both type 1 and type 2 diabetics. In Novo's case, they have two kinds of long-acting insulin analogue taken 1-2 times per day for both T1 and T2; they have to my knowledge the only ultra-long-act…

Insulin prices have inflated by about 500% over the past two decades in the United States. Novo Nordisk's profits have seen a similar rise. Now, im no economitician, but I'd wager a vial of Fiasp® that there's more than just supply and demand going on here.

The price of Novo insulin in Denmark has not risen since 2005 for the products I checked.[0] So they haven't followed the price index and have thus become cheaper.

[0] https://www.medicinpriser.dk/?lng=2

Post reply on HN