I used and loved Sequel Pro for years, but interface limitations and crashes finally set me off looking for a replacement after some stressful production debugging sessions.
After trying a few like MySQL Workbench and Navicat, I landed on Querious and haven't looked back since. It's not free in either sense of the word but well worth the ~$50 USD license IMO.
Interface-wise I found it to be easier/more familiar to switch to from Sequel Pro, as compared to some of the alternatives mentioned above - more on the light and nimble side, less on the heavy interface enterprisey-feeling side if that makes sense.
It's Mac native, performant, and very stable. Some very basic features that felt like a big upgrade from Sequel Pro:
- Arbitrary WHERE clause support in the data view, so you don't need to switch to a full manual query as soon as you need slightly more complex conditions
- Multiple query tabs - I used to spawn multiple Sequel Pro instances because this was so hard to live without. There's also good management of query history and saved queries.
- Robust and performant import/export tools
No affiliation with the developer, just wanted to give a shout-out to a high quality piece of software that I've really appreciated using.