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Consumption of a dark roast coffee blend reduces DNA damage in humans

ncbi.nlm.nih.gov

81–90 of 170 posts

Re: Consumption of a dark roast coffee blend reduces DNA damage in humans

#81

Stopped drinking coffee months ago and I have never felt better. Anxiety is down. Sleeplessness is down. General mood is up. Best of all, I no longer get headaches due to Caffeine withdrawal.

I've found what was really bad, at least in my case, was drinking it every day. I was just insidiously sliding towards a state of perma-depletion.

Drinking it occasionally seems fine. As long as I think of it as a treat, it's not too bad, and may indeed help actually.

Re: Consumption of a dark roast coffee blend reduces DNA damage in humans

#82

Earlier quoted context omitted.

I'm generally sceptical of all studies about coffee for this very reason. There's a lot of bullshit studies around food and supplements funded with people with strongly vested interests in selling more product. It's a real problem. For any given supplement, you can often find multiple studies supporting its use and multiple studies saying it's harmful. When it comes to coffee specifically, if you listen to the studie…

To some extent isn't that expected? Let's face it - who would spend the money to fund a study on a substance that's been around for hundreds (thousands?) of years? Probably if you're going to spend the money to investigate it, you expect some kind of return. So sadly, all these studies end up being funded by people with an interest in a positive outcome. The bigger question to me is, does that immediately invalidate…

> The bigger question to me is, does that immediately invalidate their results?

How many times did they fund this study with different research groups, quietly round filing the results each time until they found a research group willing to p-hack a flattering result?

Re: Consumption of a dark roast coffee blend reduces DNA damage in humans

#83
post #7

Earlier quoted context omitted.

Both contain tannins. I am not suggesting that these are the cause of the benefits observed in the study.

Beer contains tannins also. Not that I need any extra excuse..

Old school leather may be infused with tannins. Should I start licking those boots now?

Re: Consumption of a dark roast coffee blend reduces DNA damage in humans

#84

Earlier quoted context omitted.

I'm generally sceptical of all studies about coffee for this very reason. There's a lot of bullshit studies around food and supplements funded with people with strongly vested interests in selling more product. It's a real problem. For any given supplement, you can often find multiple studies supporting its use and multiple studies saying it's harmful. When it comes to coffee specifically, if you listen to the studie…

> However, it's a stimulant, it increases cortisol (stress hormone). Stimulants generally makes the body prioritize immediate energy spending over regeneration/healing. There's been a study claiming that caffeine decreases neurogenesis, which should negatively impact both long-term memory and mood. All true. Now, by the same token, I am wondering about the effects of decaf. You know, all the alleged "good stuff", non…

You know how coffee is decaffinated, right?

Edit to address Florin_Andrei's critique: last I checked, the organic solvent processes predominant. Just a gestalt, but I suspect there are some adducts produced and the separation, though evaporative, is still imperfect.

Just something to keep in mind.

Re: Consumption of a dark roast coffee blend reduces DNA damage in humans

#85
post #43
post #2

Quick googling indicates that tea has similar effect https://www.ncbi.nlm.nih.gov/pubmed/24585444 (very small study but effect size is good), another study is https://academic.oup.com/jn/article/138/8/1567S/4750818 What are the common ingredients in coffee and tea except caffeine? EDIT: It seems like black tea also, although I can't make sense of the biological jargon. https://pubs.acs.org/doi/abs/10.1021/jf010875c

Why couldn't caffeine be the main mechanism-of-action? It's a diuretic, so those treated with coffee likely drank more total liquids during the study, and perhaps flushed more older/damaged cell material.

Not a biologist or a doctor, but I'm pretty sure you don't pee out damaged cells.

Re: Consumption of a dark roast coffee blend reduces DNA damage in humans

#86

I drink coffee nearly every day; I am reading this in a coffeeshop. But, p = 0.028? Come on. If you tested for a few dozen things, you would expect to find at least one that had a p-value like that. Was this pre-registered to look at only DNA damage, via this metric? Or did they look at 100 different things to find one with p=0.028? Of course, if they pre-registered and their theory was that it would reduce DNA damag…

It's a little annoying if they're cherry-picking but does it really impact the validity of the results? If anything, I'd think they'd have a greater incentive to skew results if they were specifically testing a theory about DNA damage.

Yes, p-hacking and related techniques do impact the validity of the results. More on that here: https://info.umkc.edu/drbanderson/p-hacking-and-the-problem-...

Re: Consumption of a dark roast coffee blend reduces DNA damage in humans

#87
post #70

While the research may be compromised by a conflict of interest, I still have a legit question. Trader Joe's discontinued my favorite dark roast coffee (Fair Trade Organic Guatemalan) and nothing I've found has come close to the taste and cost. http://www.traderjoesreviews.com/product/trader-joes-fair-tr... Does anyone have a suggestion for me that's ~$10-$12 per pound?

Have you tried Peet’s Big Bang? It’s medium roast but definitely has the flavor of darker roasts.

Re: Consumption of a dark roast coffee blend reduces DNA damage in humans

#88

Earlier quoted context omitted.

> However, it's a stimulant, it increases cortisol (stress hormone). Stimulants generally makes the body prioritize immediate energy spending over regeneration/healing. There's been a study claiming that caffeine decreases neurogenesis, which should negatively impact both long-term memory and mood. All true. Now, by the same token, I am wondering about the effects of decaf. You know, all the alleged "good stuff", non…

You know how coffee is decaffinated, right? Edit to address Florin_Andrei's critique: last I checked, the organic solvent processes predominant. Just a gestalt, but I suspect there are some adducts produced and the separation, though evaporative, is still imperfect. Just something to keep in mind.

I mean I can read this just like anybody with an internet connection

https://en.wikipedia.org/wiki/Decaffeination#Decaffeination_...

but you'd have to be more specific as to what your concerns are.

Re: Consumption of a dark roast coffee blend reduces DNA damage in humans

#90

I drink coffee nearly every day; I am reading this in a coffeeshop. But, p = 0.028? Come on. If you tested for a few dozen things, you would expect to find at least one that had a p-value like that. Was this pre-registered to look at only DNA damage, via this metric? Or did they look at 100 different things to find one with p=0.028? Of course, if they pre-registered and their theory was that it would reduce DNA damag…

It's a little annoying if they're cherry-picking but does it really impact the validity of the results? If anything, I'd think they'd have a greater incentive to skew results if they were specifically testing a theory about DNA damage.

> "It's a little annoying if they're cherry-picking but does it really impact the validity of the results?"

Yes, that's a well known method of p-hacking.

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