Here's an interesting stack: https://github.com/ornicar/lila It's the server/client for https://lichess.org/ which is a powerful online chess server. Scalla with Akka actors is used to provide realtime multiplayer chess (bullet chess games, where each player only has a minute or two to play an entire game, are very popular there). The client-side is written in TypeScript, and rather than use React for the vdom, they'…
I'm a regular HN reader, yet I've never heard of half of these. This doesn't sound like the kind of stack you'd want to adopt if you ever want anybody else to work on the code.
This is probably not the go-to stack but not for the reasons you've stated.