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Ibuprofen alters human testicular physiology to produce compensated hypogonadism

ncbi.nlm.nih.gov

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Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#231

Post by Escolte »

zzzcpan wrote: post #212
Escolte wrote: post #211

Earlier quoted context omitted.

I was prescribed to take Naproxen, another NSAID with potentially the same harmful effects as Ibuprofen, for two weeks three times a day half a dose. I'm from Spain. But IDK. Let me reiterate that everyone all around the world uses Ibuprofen.

I'm curious, did you have naproxen/ibuprofen at home before they prescribed it to you? Probably not, but I bet you have aspirin at home.

Nope, but Aspirin, Ibuprofen and Paracetamol yes, since they are considered "staple" medicine.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#232

Post by Fjolsvith »

Valmar wrote: post #189
an_account_name wrote: post #39

Earlier quoted context omitted.

Fevers kill. Ibuprofen and acetaminophen reduce fevers.

Fevers are used by the body in an attempt to weaken invading bacteria and viruses, and make it easier for the body to heal. You don't want to stop a fever ~ just keep it within the safe zone where it's healing, but not dangerous.

I use my hot tub at 105 degrees to give me fever benefits without the bodily energy expenditure.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#233

Post by coldtea »

sgt101 wrote: post #217
coldtea wrote: post #177

Earlier quoted context omitted.

> how often do you measure the child's temperature As often as you need when they have a fever. Modern thermometers can give you the temperature in a minute or so.

yes, but is this sampling a good idea? Have you tried measuring temperatures periodically when the child appears well? What is the variation then? How do you know that the device is telling you something meaningful? Is the child getting flustered and hotter because of the attention?

>yes, but is this sampling a good idea? Have you tried measuring temperatures periodically when the child appears well? What is the variation then?

There should be no major variation then. On the other hand, if the child reaches 38+ or so, you need to be on the lookout...

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#234

Post by naasking »

cyphar wrote: post #228
naasking wrote: post #203

Earlier quoted context omitted.

> Paracetamol (or acetaminophen) can cause liver failure if you take too high a dose Sure, and drinking too much water causes hypernutremia that can also kill you. Toxicity is always dose dependent, so the initial unqualified claim seemed to imply toxicity at normal dosages.

Botulinum toxin (botox) doesn't kill most people in the standard dosage, but it is obviously toxic (it's in the name). Paracetamol poisoning is fairly common, hypernutremia isn't. Don't get me wrong, I disagree with the original statement that paracetamol is toxic (with the implication that this is a reason not to use it in normal dosages). But it's definitely not harmless.

I agree it's not harmless, but strictly speaking this kind of phrase is meaningless because nothing is intrinsically harmless. Dosage dictates all harm.

Probably the closest to harmless you can get are the inert gasses, and even then they can cause harm by displacing oxygen to deadly levels.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#235

Post by drb91 »

Flashtoo wrote: post #166
drb91 wrote: post #71

Earlier quoted context omitted.

OTOH acetaminophen is known to be toxic; is there an alternative here for non narcotic inflammation, fever, and pain relief that is shown NOT to have tradeoffs for use?

Acetaminophen/paracetamol is really only toxic in higher doses due to its metabolism, as only the intermediate metabolite NAPQI is toxic, but that cannot build up in low doses.

Still, it seems just as easy to have too much of a dose or acetaminophen in a single day as it is to use ibuprofen continually for an extended period of time.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#236

Post by cfmcdonald »

Ibuprofen has been taken regularly in substantial doses by millions of people for decades. The prior probability that it has some heretofore unknown serious side effect is very low, so it would take a lot of evidence to convince me that this is real.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#237

Post by conanthe »

braythwayt wrote: post #155
conanthe wrote: post #145

Earlier quoted context omitted.

Kratom / Cannabis oh wait these are illegal so big pharma can milk their poisons.

Here in Canada, Big Pharma are falling over themselves to get into the Cannabis business. I honestly think the obstacle to Cannabis legalization in the US is social conservatism, not industrial lobbying.

I think finally people elected someone who isn't corrupt. I really admire Canadian PM for his bravery and spine. Big pharma _has to_ get in, because the cracks in the dam are too big now. Obstacle to legalisation was no access to information. Now people have internet and can see clearly how they have been lied to. I know no conservative who would call that conservatism. This is deception and corruption. Only people who want to keep the status quo are uninformed, profiting or ignorant. In some parts of the world a politician mentioning legalisation risks getting killed.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#238

Post by justtopost »

naasking wrote: post #203
cyphar wrote: post #181

Earlier quoted context omitted.

Paracetamol (or acetaminophen) can cause liver failure if you take too high a dose[1] (this is one of the reasons you are told not to drink alcohol when taking paracetamol -- if your liver is struggling to process alcohol you're more susceptible to liver failure). In fact, paracetamol poisoning is the primary cause of death in overdoses (in the US, UK, Australia and New Zealand)[2]. And in 2006, [3] found it was the…

> Paracetamol (or acetaminophen) can cause liver failure if you take too high a dose Sure, and drinking too much water causes hypernutremia that can also kill you. Toxicity is always dose dependent, so the initial unqualified claim seemed to imply toxicity at normal dosages.

It is easily the most lethal otc. Its not some dihydrogen monoxide fear mongering.

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#239

Post by ada1981 »

ada1981 wrote: post #163
logicchains wrote: post #131

Earlier quoted context omitted.

Painkillers are not side effect free; if the pain is something minor, like a bruised knee or normal headache, it's not unreasonable to decide that experiencing the pain is a better choice than risking the side effects of a drug, which in uncommon cases can be much more severe and long term. It's not as clear cut as "helping" vs not helping, as unfortunately we don't yet have any side effect free painkillers.

You could also teach your kids meditation techniques to be deployed when in pain.

Unsure why this got downvoted, meditation has been show to reduce pain up to 90%.

Seems like teaching kids to meditate would have all sorts of benefits, including drug free pain management.

https://www.psychologytoday.com/us/blog/mindfulness-in-frant...

Re: Ibuprofen alters human testicular physiology to produce compensated hypogonadism

#240

Post by conanthe »

cycrutchfield wrote: post #154
conanthe wrote: post #145

Earlier quoted context omitted.

Kratom / Cannabis oh wait these are illegal so big pharma can milk their poisons.

Cannabis causes low T and gynecomastia, so not really

Citations are "studies" from Nixon era. "Scientists" only could be allowed to study cannabis for bad effects and that was the only way to get funding. This is all crap my friend.
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