Yes. I've been involved in home automation for many many years. Our house has pretty much all the primary lights and outlets controlled by Insteon devices. A Mac Mini runs a software called Indigo that handles all the logic and macros, the same Mini has our primary audio library on it, and some other media.
Every plasma TV in the house also has a Mac Mini at a minimum, some also have Tivos and Apple TVs.
Intelligent video cameras around the house can detect people or vehicles approaching up the driveway or around other perimeter areas and send me email alerts, video clips and/activate other things via the Indigo/Insteon system.
We have a dual-zone heating/cooling setup. The thermostats are Venstars with an Insteon RF interface. Setpoints are selected based on time of day, outdoor temps, and occupancy (sensed via motion detectors and/or our presence at our other house (eg: if there is activity at house X, we can keep house Y from initiating common events)).
I have a Redeye wifi to IR iPod base station thing for controlling the TV and AV gear we spend most time around. This is mostly accessed through an I* app, but can also be controlled via an http interface.
From a web interface, my iPhone or my iPad I can turn any light on or off, change temperature setpoints, read status of various sensors, or control iTunes, all through the Indigo app. Through a separate web interface I've written, I can see recent events from the security cameras and access control systems, see live video, lock/unlock certain doors and so forth.
There is a Russound multi-zone amp and zone selector in the basement ( though we mostly just use the amp now). A combination of airport expresses and rogue amoeba apps allows me to route audio from pretty much any device/point in the house to any other device or room. There are in-ceiling speakers in the bedroom and master bath, speakers in the garage, and on the back deck, all on separate zones.
I've run about 2 miles of cable (cat5 and rg6) throughout the house to create a communications backbone.
I'm probably missing a few things, but the summary of it is that the houses mostly adapt around us for things like lights and hvac. We can listen to music anyplace we happen to be ( there is almost always music playing at our house).
The current incarnation of the system is the result of hacking around with HA for about a dozen years now trying different things to see what works. When I first started doing this my wife was basically like 'NFW' and now she wouldn't want to live without it.