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The Link Between Inflammation and Depression?

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Re: The Link Between Inflammation and Depression?

#41

Earlier quoted context omitted.

https://www.mdedge.com/fedprac/article/81232/mental-health/n...

I'd caution anyone making a link between depression and NSAIDs from that paper. Most of those people probably climbed out of depression because they specifically administered pain medication to subjects with osteoarthritis. Suddenly being rid of chronic pain can be liberating.

Rethinking this relationship is a major point of the original thread/article.

Re: The Link Between Inflammation and Depression?

#42
post #27

I suffered from suicidal depression, anxiety, mania, psychosis, paranoia, panic attacks and more. I flirted with diagnosis of schizoaffective disorder to bipolar. My life was pretty out of control. I didn’t like the outcomes I saw of people who were on meds their entire life and I didn’t buy the story from mainstream psychiatry. I found MDMA therapy via an underground practice and it transformed my life over the cour…

Can you point to anything scholarly about Holotropic Breathwork? I'm curious, but my searches turn up very... "crystal woo-woo" stuff. :(

Re: The Link Between Inflammation and Depression?

#43
post #26

This is very important. It’s not yet fully understood, but something is missing yet in our understanding of inflammation. It’s not everything, just like antibiotics weren’t everything, but progress here will mean curing an incredible amount of human suffering. The book linked below, a late 2015 text on Molecular Neuropharmacology, is fascinating. Every chapter has a mention of inflammation and usually ibuprofen. It’s…

Interesting definitely adding this to my reading list for self serving reasons. I independently came to similar ideas about inflammation, mostly because I have to take a lot of Ibuprofen for chronic pain and what works best is taking some preemptively on non painful days. That is, I always tried to think up more reasons for why this isn't a terrible idea.

tumeric might be more powerful.

Re: The Link Between Inflammation and Depression?

#44

We don't know about severity of the depression when we say depression. My friend has racing thoughts, feeling tired all time, unable to move, unable to think. Negatives thoughts amplifying to point where nothing no longer makes sense. Can such depression be treated? When she was born, she had a serological conflict. 1. She first recognized it at age 8. 2. Now she's 18 3. Tried sucide at 16 It's not like she doesn't w…

I wonder if changing the gut bacteria might provide her a route to health. A serological impact would deprive her of bacteria that could reduce imflamation

Re: The Link Between Inflammation and Depression?

#45

Earlier quoted context omitted.

what worked in your case?

I suffer from PTSD due to childhood trauma which is ultimately the cause of my anxiety, depression, mood swings, etc,. Right now I’m seeing a therapist who specializes in trauma and going through EMDR (eye movement desensitization and reprocessing) treatment. I’ve also taken Wellbutrin (anti-depressant) and Lamictal (mood stabilizer) for the last 18 months or so. I also just have to constantly keep busy. I fill my ti…

Have you ever tried Psilocybin? In combation with your therapy I could see success.

Re: The Link Between Inflammation and Depression?

#47
This psychiatrist spouting off the "serotonin imbalance" marketing speak from big pharma like it's science is frightening. This has actually never been proven to exist, which is why every ad for SSRIs states "the way this drug is believed to work is...".

And then there's all the terrible side effects they never tell you about before you start taking them, and the fact you likely won't be able to stop using them without horrible withdrawal symptoms...

So much about psychiatry is still more akin to shamanism than actual science and medicine it's frightening.

Re: The Link Between Inflammation and Depression?

#48
post #34

Earlier quoted context omitted.

Did you also eat less sugar/carbs? Because I think sugar is the main culprit.

Sugar and refined carbs can also cause inflammation but I cut those out of my diet years ago. I didn't see the real benefits until I switched to a plant based diet.

I don't want to be that guy again (I've been heavily downvoted in every nutrition threads I contributed in HN), please understand that I'm trying to learn and improve myself. But I'm curious how did you come up with a plant-based diet that's not high in sugar. As far as I know pretty much all (except very few) plant based food are very high in sugar. Especially most fruits have exorbitant amounts of fructose. I usually eat high fiber veggies (like broccoli, brussel sprouts, soybeans etc...) but it doesn't give much variety. Remember that most animal based food (eggs, most cheese, chicken, turkey, red meat, fish etc) are 0 sugar. Also, nuts are low carb, high fat but they're very high in Omega 6 (except walnut and some seeds like flaxseed) and there is some research indicating synergy between sugar and Omega 6 for inflammation (I can find the link if you want, but I'm too tired right now). I'm all for veganism but I can never find a suitable vegan cookbook. People say veganism is easy, as far as I'm concerned this is simply not true. If you go full vegan you have absolutely no choice other than soybeans to get adequate amount of protein. Any other protein source such as beans are very high in carbs (e.g. 600 cal of black beans have only 40g of protein (which is only 1/3 of my daily need as a bodybuilder) but have 116g of carbs only 30g of which fiber, in my book a very unhealthy food). And since you cannot supplement your diet with seafood, you have very few choices of Omega 3 sources (various seeds, acai berry, walnut come to mind).

To make myself clear: I think vegan diet is efficient, sustainable and ethical. But there is simply no easy way to go full vegan and get enough macro nutrients (in particular protein, and fats) without getting a lot of sugar. I have a lot of problem with inflammation and even 5g of sugar is too much for me, so it seems like the only plant based food I can eat are soybeans and broccoli. Maybe I'm missing something. Care to help?

Re: The Link Between Inflammation and Depression?

#49
post #27

I suffered from suicidal depression, anxiety, mania, psychosis, paranoia, panic attacks and more. I flirted with diagnosis of schizoaffective disorder to bipolar. My life was pretty out of control. I didn’t like the outcomes I saw of people who were on meds their entire life and I didn’t buy the story from mainstream psychiatry. I found MDMA therapy via an underground practice and it transformed my life over the cour…

Can you point to anything scholarly about Holotropic Breathwork? I'm curious, but my searches turn up very... "crystal woo-woo" stuff. :(

Stan Grof developed it as an alternative to LSD psychotherapy after prohibition.

Basically the framework I formed looked like this:

Depression and other mental illness are very often caused by an adaptive response to trauma.

Trauma heals in the space of non-ordinary states of conciousness in the right set and setting.

There are numerous paths into non-ordinary states, including psychedelics, EDMR and Breathwork.

Breathwork uses loud rythmic music and hyper ventilation in a supported group context to induce a useful non-ordinary state.

I should say, I thought this was woo woo bs. But holy shit, it will take you on a journey- I was blown away. And also it was super useful to integrate the MDMA sessions.

Re: The Link Between Inflammation and Depression?

#50
post #27

I suffered from suicidal depression, anxiety, mania, psychosis, paranoia, panic attacks and more. I flirted with diagnosis of schizoaffective disorder to bipolar. My life was pretty out of control. I didn’t like the outcomes I saw of people who were on meds their entire life and I didn’t buy the story from mainstream psychiatry. I found MDMA therapy via an underground practice and it transformed my life over the cour…

I am very glad this worked for you, but isn't MDMA a psychiatric med?

It’s currently in Phase 3 for PTSD after spending a couple decades in prohibition.

It’s not a sanctioned medicine yet, and historically has been outside the bounds of western psychiatry.

And when I mean no psychiatric meds I mean nothing ongoing.

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