I have found for myself that taking Ibuprofen eases both anxiety and depression. It's not a cure but it surprises me how much of a mental effect a mild analgesic has.
Would anyone have an idea why this could potentially be?
The Link Between Inflammation and Depression?
11–20 of 93 posts
Re: The Link Between Inflammation and Depression?
#12Not only we don’t understand the mechanism causing depression, we don’t really understand (as far as I am aware) why medications work or don’t work. I deal with mild depression sometimes, but this scares me off of considering medication for it. I’ve encountered so many horror stories of withdrawal symptoms... you really need to be at a point of desperation to consider drugs for it, imo.
I think a larger problem is that it’s such a crapshoot about which treatments will work for a given individual, pharmaceutical or not. It took me about 10 therapists with varying backgrounds before I finally found one that would help. It also took me trying several different medications to find a combination that’s actually effective. It’s a lot of work and effort, and most people suffering through depression, anxiet…
what worked in your case?
Re: The Link Between Inflammation and Depression?
#13Not only we don’t understand the mechanism causing depression, we don’t really understand (as far as I am aware) why medications work or don’t work. I deal with mild depression sometimes, but this scares me off of considering medication for it. I’ve encountered so many horror stories of withdrawal symptoms... you really need to be at a point of desperation to consider drugs for it, imo.
Most medications DON'T work for most people. For example here[1] is a meta-analysis from 2004 of the top 6 antidepressants which finds that 80% of the effect is achieved by placebo, and the remaining effect is statistically, but not clinically, significant (that is, the effect size is tiny). Here[2] is another follow-up that shows that there may be effects only in the most severely-depressed patients. In addition the…
Do none of your friends have severe depression? CBT doesn't work for severe depression without medication in my experience.
Re: The Link Between Inflammation and Depression?
#14We don't know about severity of the depression when we say depression.
My friend has racing thoughts, feeling tired all time, unable to move, unable to think.
Negatives thoughts amplifying to point where nothing no longer makes sense.
Can such depression be treated?
When she was born, she had a serological conflict.
1. She first recognized it at age 8.
2. Now she's 18
3. Tried sucide at 16
It's not like she doesn't want to get better. She has everything good going for her but her body/brain isn't helping her.
Now, this article makes me wonder if she had this depression since birth and only understood it by 8.
And wether she is still affected by antibodies eating out her cells?
Tho i don't have any real sister but she is like my own sister.
I am willing to spend all my money to see her cured from this depression. But nothing has worked so far.
Re: The Link Between Inflammation and Depression?
#15Not only we don’t understand the mechanism causing depression, we don’t really understand (as far as I am aware) why medications work or don’t work. I deal with mild depression sometimes, but this scares me off of considering medication for it. I’ve encountered so many horror stories of withdrawal symptoms... you really need to be at a point of desperation to consider drugs for it, imo.
My first experience with an antidepressant left me feeling quite ill. Ironically, its one of the ones that gets prescribed often because it has little side-effects. Turned out that this wasn't true, and I was one of the small percentage who experienced Discontinuation Syndrome ( https://www.karger.com/Article/FullText/370338 ). Having such a bad reaction to it lead me down a wild goose chase toward finding out the wa…
Genetic tests seem pointless. It's cheaper and faster to take the drug and find out if one is a responder.
Re: The Link Between Inflammation and Depression?
#16Earlier quoted context omitted.
Most medications DON'T work for most people. For example here[1] is a meta-analysis from 2004 of the top 6 antidepressants which finds that 80% of the effect is achieved by placebo, and the remaining effect is statistically, but not clinically, significant (that is, the effect size is tiny). Here[2] is another follow-up that shows that there may be effects only in the most severely-depressed patients. In addition the…
Do none of your friends have severe depression? CBT doesn't work for severe depression without medication in my experience.
[deleted]
Re: The Link Between Inflammation and Depression?
#17Not only we don’t understand the mechanism causing depression, we don’t really understand (as far as I am aware) why medications work or don’t work. I deal with mild depression sometimes, but this scares me off of considering medication for it. I’ve encountered so many horror stories of withdrawal symptoms... you really need to be at a point of desperation to consider drugs for it, imo.
Did you try Withania, i wonder why it's never prescribed bu anyone:
https://examine.com/supplements/ashwagandha/
Re: The Link Between Inflammation and Depression?
#18Not only we don’t understand the mechanism causing depression, we don’t really understand (as far as I am aware) why medications work or don’t work. I deal with mild depression sometimes, but this scares me off of considering medication for it. I’ve encountered so many horror stories of withdrawal symptoms... you really need to be at a point of desperation to consider drugs for it, imo.
Most medications DON'T work for most people. For example here[1] is a meta-analysis from 2004 of the top 6 antidepressants which finds that 80% of the effect is achieved by placebo, and the remaining effect is statistically, but not clinically, significant (that is, the effect size is tiny). Here[2] is another follow-up that shows that there may be effects only in the most severely-depressed patients. In addition the…
Do you know you're listing a paper widely described as one of the most controversial psychology papers?
Here's a response, using the same data, but getting different results: https://annals-general-psychiatry.biomedcentral.com/articles...
> The results reported here conclude the debate on the efficacy of antidepressants and suggest that antidepressants are clearly superior to placebo. They also suggest that baseline severity cannot be utilized to dictate whether the treatment should include medication or not. Suggestions like this, proposed by guidelines or institutions (e.g. the NICE), should be considered mistaken.
Re: The Link Between Inflammation and Depression?
#19Earlier quoted context omitted.
I think a larger problem is that it’s such a crapshoot about which treatments will work for a given individual, pharmaceutical or not. It took me about 10 therapists with varying backgrounds before I finally found one that would help. It also took me trying several different medications to find a combination that’s actually effective. It’s a lot of work and effort, and most people suffering through depression, anxiet…
what worked in your case?
I have bipolar disorder and take a stimulant, a mood stabilizer, and sometimes an antidepressant. I’ve done my best to make my personal and professional work schedule comfortable, do mindful breathing exercises, take almost all my meeting outside and walking, and try to exercize 3 times a week. It’s a lot to manage while having a family but it’s very worth it IMO
Re: The Link Between Inflammation and Depression?
#20Earlier quoted context omitted.
My first experience with an antidepressant left me feeling quite ill. Ironically, its one of the ones that gets prescribed often because it has little side-effects. Turned out that this wasn't true, and I was one of the small percentage who experienced Discontinuation Syndrome ( https://www.karger.com/Article/FullText/370338 ). Having such a bad reaction to it lead me down a wild goose chase toward finding out the wa…
Genetic tests seem pointless. It's cheaper and faster to take the drug and find out if one is a responder.
I think what s/he's referring to are tests for mutations in certain liver enzymes that are known to interfere with a drugs function. These are cheap and quick tests (these aren't sequencing based tests) and quite good at predicting non-responders
On the other hand it can take 4-6 weeks to see if someone responds to a drug, and the drug can cause adverse events in addition to not treating the disease
So in this case it is cheaper, faster and safer to take the test before prescribing