Deformities Alarm Scientists Racing to Rewrite Animal DNA

Post by goatlover » Sat, Dec 22, 2018, 11:01 PM UTC

anigbrowl wrote: post #119

akira2501 wrote: post #108

Earlier quoted context omitted.

> From my laymans POV It's just so much more complicated than that. There is an additional huge array of variables like introns[1] and exons[2]. There's also the fact that not all base pairs encode even for genes, there's things like tRNA[3] and ribosomes[4] and the super amazing ribozymes[5]. Even after all that you have specific DNA binding factors[6] that along with the insane machinery[7] of our DNA regulate whic…

C may let you shoot yourself in the foot, C++ may let you blow your whole leg off, but only CRISPR will let you turn it back into a tentacle.

Post by ejstronge » Sat, Dec 22, 2018, 11:24 PM UTC

rubatuga wrote: post #123

Article says they are using an "older method" of gene editing. Well no wonder then, we know that older gene editing methods have a lot of off target effects, crispr cas9 using base modification (instead of deleting whole DNA stretches by splicing) is very safe. This is a FUD article.

Post by aetherson » Sat, Dec 22, 2018, 11:38 PM UTC

hanniabu wrote: post #141

cronix wrote: post #57

From my laymans POV, DNA is just a shit ton of variables in a very complex code that interact with each other. No single point just does a single thing. They all interact with each other. No different than changing a variable in one piece of code and having it create a bug in another that was previously working. For me, the real scary part is altering something, which inadvertently changes something else that isn't q…

> Something like "everybody will get Alzheimers by age 50" where it takes 50 years to even discover it. Yup, and my then the market is established and the companies creating the market will say it's impossible to know that the side effect was actually caused by altering your DNA, and go on knowingly selling services that are destroying lives all in the name of money

Post by mdtancsa » Sat, Dec 22, 2018, 11:46 PM UTC

jayalpha wrote: post #132

smaddox wrote: post #69

Earlier quoted context omitted.

GM foods are arguably no more dangerous than any massively engineered foods we've been eating for decades/centuries. Direct gene modification is more like using a scalpel rather than a 2x4. Still potentially dangerous, but far more precise.

"GM foods are arguably no more dangerous than any massively engineered foods " This may be your opinion. While GM foods are not per see dangerous, the long tail risk is tremendous, exactly because you can not tell what a gene is going to do in another organism. Take my word for it, I have a PhD in that shit. Taleb also advocates the precautionary principle: https://arxiv.org/pdf/1410.5787.pdf

Post by ummonk » Sat, Dec 22, 2018, 11:58 PM UTC

akira2501 wrote: post #108

cronix wrote: post #57

From my laymans POV, DNA is just a shit ton of variables in a very complex code that interact with each other. No single point just does a single thing. They all interact with each other. No different than changing a variable in one piece of code and having it create a bug in another that was previously working. For me, the real scary part is altering something, which inadvertently changes something else that isn't q…

> From my laymans POV It's just so much more complicated than that. There is an additional huge array of variables like introns[1] and exons[2]. There's also the fact that not all base pairs encode even for genes, there's things like tRNA[3] and ribosomes[4] and the super amazing ribozymes[5]. Even after all that you have specific DNA binding factors[6] that along with the insane machinery[7] of our DNA regulate whic…