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Depression

robertsapolskyrocks.com

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Re: Depression

#61

Post by DanBC »

claudiawerner wrote: post #59
IAmGraydon wrote: post #26

Earlier quoted context omitted.

Exactly. Most people who suffered trauma at an early age cannot identify it without working through it with a therapist.

I thought this much was obvious; the idea that one can necessarily simply remember trauma was banished very early in the fields of psychology and psychoanalysis. It's a little disappointing to see that people continually underestimate the power of the unconscious.

The idea that people can't remember trauma but that it still affects them, and what we really need to do is to uncover those repressed memories has caused immense harm.

Re: Depression

#62

Post by claudiawerner »

DanBC wrote: post #61
claudiawerner wrote: post #59

Earlier quoted context omitted.

I thought this much was obvious; the idea that one can necessarily simply remember trauma was banished very early in the fields of psychology and psychoanalysis. It's a little disappointing to see that people continually underestimate the power of the unconscious.

The idea that people can't remember trauma but that it still affects them, and what we really need to do is to uncover those repressed memories has caused immense harm.

That was my point, but other commenters seemed to be saying that if you can't remember trauma then you must never have been traumatised, which is a false thing to say.

Re: Depression

#63

Post by datafatmunger »

In this lecture, Sapolsky talks briefly about the genetic component but at a super high level "good/bad" version of a gene.

Depression is a genetic disorder. It has some degree of heritability. 50% identical twins, 25% full sibling. So again we have the whole nature-nurture interaction. Have the bad gene (a serotonin one), add in major stressors and uh-oh. A 30 fold increase in the likelihood of depression at the extreme. Oh, and glucocorticoids regulate the expression of the gene.

Anyone know what gene he is referring to?

Re: Depression

#64

Post by mabbo »

TheSpiceIsLife wrote: post #34
mabbo wrote: post #18

Earlier quoted context omitted.

On the one hand, answers like this always seem to over-simplify. Oh hey just take this vitamin and the soul sucking demon that's been riding on your shoulder for years, decades, will magically go away. On the other, I spent nearly two decades of my life suffering from this horrendous illness, and nothing has helped as much as daily magnesium does. I take a big Magnesium pill, a men's health multivitamin and I add D i…

Yeah, on the one hand I'm strongly against drive-by one liners, on the other hand vitamin D cured me . I was already taking magnesium, B6 ... everything else. 8000 to 12000IU of Vitamin D a day for four weeks weeks cured me of my suicidal ideation / depression / emotional instability / irritability. I went to the doctor and got a prescription for antidepressants a couple of times, drove to the pharmacist and sat in t…

Yeah, I added the vitamin D after spending most of a winter in Edinburgh. Lovely city- but it's 56 degrees north. That city will get less than 7 hours of daylight today.

Re: Depression

#65

Post by datafatmunger »

datafatmunger wrote: post #63

In this lecture, Sapolsky talks briefly about the genetic component but at a super high level "good/bad" version of a gene. Depression is a genetic disorder. It has some degree of heritability. 50% identical twins, 25% full sibling. So again we have the whole nature-nurture interaction. Have the bad gene (a serotonin one), add in major stressors and uh-oh. A 30 fold increase in the likelihood of depression at the ext…

So, I'm guess maybe this one: https://www.ncbi.nlm.nih.gov/snp/rs25531#frequency_tab

...and despite: "According to David Hinds of 23andMe on community forums, "nearly everyone (99.97%) is getting called as CC, and there is no clear heterozygote cluster" ... "the genotype calls for rs25531 on our platform are not meaningful." Looking at OpenSNP frequency data, this seems to be universal for direct to consumer genotyping services at this stage.... "

... but went looking for this in my own data anyway, and couldn't even find the rs#.

disclaimer: I have no idea what i'm doing.

Re: Depression

#66

Post by quantum_state »

I had the good fortune to watch the lectures some years ago and the helped my understanding greatly. Just would like to share this and encourage everyone to take a close look.

Re: Depression

#67

Post by mabbo »

projektir wrote: post #28
mabbo wrote: post #18

Earlier quoted context omitted.

On the one hand, answers like this always seem to over-simplify. Oh hey just take this vitamin and the soul sucking demon that's been riding on your shoulder for years, decades, will magically go away. On the other, I spent nearly two decades of my life suffering from this horrendous illness, and nothing has helped as much as daily magnesium does. I take a big Magnesium pill, a men's health multivitamin and I add D i…

Iron / Vitamin D / and maybe Magnesium (this one is still new for me and I can't find a good way to get it. What's a good brand for this?) is always my first check for whenever I fall into a slump. If you are depressed/whatever always check your stats if you haven't already (i.e., take a blood test, check your vitamins). Maybe it won't help, but better get that out of the way because those things can make a dramatic…

I've been taking this magnesium: https://www.amazon.com/dp/B000BD0RT0

But I think it may have been discontinued or changed recently- my orders on Amazon say the ASIN that I ordered no longer exists? Regardless, "Magnesium Glycinate Lysinate Chelate" is the keywords I'm looking for when I find a new source.

I'm taking a single 100mg pill per day, though I've recently noticed the recommended dose is 200mg. shrug I guess 100 is enough for me, when combined with my other dietary intake.

Re: Depression

#70

Post by TheSpiceIsLife »

_0w8t wrote: post #58
TheSpiceIsLife wrote: post #49

Earlier quoted context omitted.

I didn’t bother with a test, the symptoms, when I finally connected the dots, were indicative enough for me to give it a go. It’s not uncommon for doctors around these parts to prescribe pharmastist depended 20,000IU gel caps, after a test of course. Also, there was an article doing the rounds a few months back indicating we neee way more vitamin D than the current guidelines. I’ll see if I can dig it up. Edit to add…

One is strongly advised to measure D to get the levels of both D25 and D1,25 forms of D when one suspects D deficiency. Normally only D25 is tested, but that may miss the case of low D25 and high D1,25. This happens with some chronic infections when the body shifts D towards D1,25 to rise immune system activities. Taking D supliments then suppresses immune system. As a result one may feel better as there is less dead…

I haven't heard of this axis before.

Can you point me to some further reading, thanks.

I'm not in any high-risk categories for asymptomatic chronic infections, so I'm not sure this is a concern.

There remains a question: should health, asymptomatic, fit / active, non-smoking, non-drinking, individuals, undergo a barrage of tests at Medicare's (public health insurer in Australia) expense?

Also, I studied nutritional medicine in a formal setting for four years, so I consider myself sufficiently qualified to make that call. Otherwise, you're probably right, it makes sense, in general, for people to have tests for nutrient deficiencies, especially if there are comorbidities.

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