New Peanut Allergy Drug Shows ‘Lifesaving’ Potential
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Re: New Peanut Allergy Drug Shows ‘Lifesaving’ Potential
#2> Though only 4.3 percent of children receiving the active drug experienced side effects categorized as severe, compared to less than 1 percent of the children on placebo...
So are they saying <1% (ie atleast one) of children on placebo experienced severe side effects?
Re: New Peanut Allergy Drug Shows ‘Lifesaving’ Potential
#3Reading around, this and related OIT work on adults. At least one of the drugs in stage2 trials is also good for asthma. (etokimab)
As a partner of somebody with severe nut anaphylaxis I'm heartened by the news but still watching from the sidelines
Re: New Peanut Allergy Drug Shows ‘Lifesaving’ Potential
#4> Though only 4.3 percent of children receiving the active drug experienced side effects categorized as severe, compared to less than 1 percent of the children on placebo... So are they saying <1% (ie atleast one) of children on placebo experienced severe side effects?
Well, less than one percent can also be zero, but yes, maybe some of the children on placebo experienced severe side effects. It doesn't mean they were related to the placebo.
Re: New Peanut Allergy Drug Shows ‘Lifesaving’ Potential
#5> Though only 4.3 percent of children receiving the active drug experienced side effects categorized as severe, compared to less than 1 percent of the children on placebo... So are they saying <1% (ie atleast one) of children on placebo experienced severe side effects?
Placebo is strong medicine.
(It’s also possible this person had an unrelated condition)
Re: New Peanut Allergy Drug Shows ‘Lifesaving’ Potential
#6> Though only 4.3 percent of children receiving the active drug experienced side effects categorized as severe, compared to less than 1 percent of the children on placebo... So are they saying <1% (ie atleast one) of children on placebo experienced severe side effects?
It’s because they don’t have a good causality link for adverse effect. If something bad happens, you’re not sure it’s because of the treatment.
So in the accounting, you take everything adverse against the treatment, wether it’s the placebo or the medicine under test, and you compare the difference between the two as rate of adverse effect for the medicine under test. And then there is a giant poker game to balance the benefits and the risks.
Re: New Peanut Allergy Drug Shows ‘Lifesaving’ Potential
#7This sounds very similar to a treatment that my daughter is due to start next year at a Cambridge allergy clinic in the UK. She'll have to take the peanut based medication every day. She will have the initial dose in a hospital in case she has a reaction and then take the remainder of the doses home. Every two weeks we'll go back to the hospital to increase the dose.
I'm very excited about the potential for this to keep her safer, but also terrified at the prospect of deliberately feeding her peanut.
Re: New Peanut Allergy Drug Shows ‘Lifesaving’ Potential
#8> Though only 4.3 percent of children receiving the active drug experienced side effects categorized as severe, compared to less than 1 percent of the children on placebo... So are they saying <1% (ie atleast one) of children on placebo experienced severe side effects?
A follow-up study is using the placebo at a higher dosage.
Re: New Peanut Allergy Drug Shows ‘Lifesaving’ Potential
#9I'll make sure my kids eat (some) peanuts/peanut products before they develop an allergy.
Re: New Peanut Allergy Drug Shows ‘Lifesaving’ Potential
#10> Though only 4.3 percent of children receiving the active drug experienced side effects categorized as severe, compared to less than 1 percent of the children on placebo... So are they saying <1% (ie atleast one) of children on placebo experienced severe side effects?
It’s because they don’t have a good causality link for adverse effect. If something bad happens, you’re not sure it’s because of the treatment. So in the accounting, you take everything adverse against the treatment, wether it’s the placebo or the medicine under test, and you compare the difference between the two as rate of adverse effect for the medicine under test. And then there is a giant poker game to balance t…
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