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Ask HN: What did you find in your DNA using 23andme?

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61–70 of 71 posts

Re: Ask HN: What did you find in your DNA using 23andme?

#61
post #8

I generally find it interesting to know as much about myself as possible: - Found out I'm the most neanderthal of anyone in my family who has been tested. - that I have the "short" genes in spite of being quite tall compared to average and the tallest in my family in my generation, my siblings have the "tall" genes in spite of being closer to average or below average respectively. - that I'm related to celebrity chef…

I'm curious, how did you discover the Batali connection? 23andMe shared that?

Re: Ask HN: What did you find in your DNA using 23andme?

#65

Earlier quoted context omitted.

You violate the terms of their service when you use a fake name. If you don't want to use your real information, pay $1000 for a full sequencing. Their rates are lower because they're able to subsidize consumers with selling aggregate information to drug companies for rapid drug prototyping and development. EDIT: I am astounded by the entitlement complex exhibited in the replies to this. You don't have to agree to th…

And I care about violating their ToS why? This is a service I'm going to use once - once I have the data from them, I no longer care about doing business with them. What's the incentive for me to care about respecting their ToS?

Well, since subsidized pricing depends on you giving real information, then you make things worse for everyone else.

If you can only enjoy something (like a lower price while giving fake information) because everyone else doesn't, then it's usually a hint that your position isn't so defendable.

Like how the only reason the guy on the bus can enjoy his music without headphones is because everyone is courteously using headphones. I mean, sure, he doesn't care. "I'll never see these people again, why would I care?" But it's weak justification for taking advantage of a situation and I think we can do better as a society.

Re: Ask HN: What did you find in your DNA using 23andme?

#66

Earlier quoted context omitted.

You violate the terms of their service when you use a fake name. If you don't want to use your real information, pay $1000 for a full sequencing. Their rates are lower because they're able to subsidize consumers with selling aggregate information to drug companies for rapid drug prototyping and development. EDIT: I am astounded by the entitlement complex exhibited in the replies to this. You don't have to agree to th…

nobody cares - they're not entitled to use your data the way they do

[deleted]

Re: Ask HN: What did you find in your DNA using 23andme?

#67
post #60
post #43

Earlier quoted context omitted.

Word of warning. Take promethease with a grain of salt. For example, promethease predicted a deletion in my genome (didn't actually observe a call, just inferred the deletion from linked sites) for a highly pathogenic disease in my data. However upon further inspection of the loci (I've done deep deep sequencing of my genome) it was a false positive. Promethease is very very useful, but it shows you all the data incl…

You mention a "deep sequencing" of your genome,, what does that look like?

Just stupidly high coverage. Something like 200x coverage over six replicates from blood and saliva. We needed DNA for QA purposes and I happen to have DNA, dontchaknow.

Re: Ask HN: What did you find in your DNA using 23andme?

#68
post #61
post #8

I generally find it interesting to know as much about myself as possible: - Found out I'm the most neanderthal of anyone in my family who has been tested. - that I have the "short" genes in spite of being quite tall compared to average and the tallest in my family in my generation, my siblings have the "tall" genes in spite of being closer to average or below average respectively. - that I'm related to celebrity chef…

I'm curious, how did you discover the Batali connection? 23andMe shared that?

They promote celebrity relatives. He's like an 8th cousin or something.

Re: Ask HN: What did you find in your DNA using 23andme?

#69
Reading this reminds me of why I am so happy to tell doctors of that fact that I am adopted when they ask about my family medical history. It is truly a blank slate.

What good can possibly come of waiting to see if you might be developing some brain malfunction like your ancestors did? But hey.. to each their own!!

Re: Ask HN: What did you find in your DNA using 23andme?

#70

My spouse did it and the results provided by 23andMe were next to useless. It told her interesting facts like that she likely has no dimples (she has them), and other meaningless crap. However, she downloaded the raw data and ran it through Promethease[0] and it did supply some useful info about potential drug interactions, which has been useful. She supplied a fake name to them, used a gift card to pay for it online…

You violate the terms of their service when you use a fake name. If you don't want to use your real information, pay $1000 for a full sequencing. Their rates are lower because they're able to subsidize consumers with selling aggregate information to drug companies for rapid drug prototyping and development. EDIT: I am astounded by the entitlement complex exhibited in the replies to this. You don't have to agree to th…

Why do they need your real name to produce aggregate information?

I am astounded by your defense of this horseshit.

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