e3/e4 APOE. Decided can take more risk backcountry skiing and other outdoor activities (live fast, die young).
Ask HN: What did you find in your DNA using 23andme?
11–20 of 71 posts
Re: Ask HN: What did you find in your DNA using 23andme?
#12My spouse did it and the results provided by 23andMe were next to useless. It told her interesting facts like that she likely has no dimples (she has them), and other meaningless crap. However, she downloaded the raw data and ran it through Promethease[0] and it did supply some useful info about potential drug interactions, which has been useful. She supplied a fake name to them, used a gift card to pay for it online…
You violate the terms of their service when you use a fake name. If you don't want to use your real information, pay $1000 for a full sequencing. Their rates are lower because they're able to subsidize consumers with selling aggregate information to drug companies for rapid drug prototyping and development.
EDIT: I am astounded by the entitlement complex exhibited in the replies to this. You don't have to agree to their terms, but don't use the service if you don't. Especially don't be infuriated that they're not holding up their end of the bargain (supposedly not destroying samples) when you flatly decided not to as well (fake name). I don't understand why that is a difficult concept to accept.
Re: Ask HN: What did you find in your DNA using 23andme?
#13Doctor Rhonda Patrick's website allows you to upload your data to and have additional analysis done:
https://www.foundmyfitness.com/genetics
Re: Ask HN: What did you find in your DNA using 23andme?
#14My spouse did it and the results provided by 23andMe were next to useless. It told her interesting facts like that she likely has no dimples (she has them), and other meaningless crap. However, she downloaded the raw data and ran it through Promethease[0] and it did supply some useful info about potential drug interactions, which has been useful. She supplied a fake name to them, used a gift card to pay for it online…
You violate the terms of their service when you use a fake name. If you don't want to use your real information, pay $1000 for a full sequencing. Their rates are lower because they're able to subsidize consumers with selling aggregate information to drug companies for rapid drug prototyping and development. EDIT: I am astounded by the entitlement complex exhibited in the replies to this. You don't have to agree to th…
If that's so, why is a real name necessary?
Re: Ask HN: What did you find in your DNA using 23andme?
#15Earlier quoted context omitted.
You violate the terms of their service when you use a fake name. If you don't want to use your real information, pay $1000 for a full sequencing. Their rates are lower because they're able to subsidize consumers with selling aggregate information to drug companies for rapid drug prototyping and development. EDIT: I am astounded by the entitlement complex exhibited in the replies to this. You don't have to agree to th…
If that's so, why is a real name necessary?
[deleted]
Re: Ask HN: What did you find in your DNA using 23andme?
#16I am a South Asian. It told me I was of South Asian ancestry. Was hoping for something more specific than that.
I love me some coffee (drink more than 3 cups a day), and it said I am very likely to consume less caffeine. It also told me I have a high chance of having smooth hair, but I have extremely curly hair.
And I am extremely skeptical of their traits in general. Some of the traits include: "cilantro taste aversion", "misophobia" (likely to hate chewing sounds), "ability to match musical pitch", "fear of heights" etc.
I am guessing they find correlations between survey answers and presence of genetic markers. A lot of these traits would also be affected by nurture not nature.
Overall, I am not happy with the experience. I don't know if it is the current state of technology or regulatory concerns holding them back from releasing better results. Another reason for their lack of specificity could be the absence of South Asian data in their datasets. Most of the disease diagnosis is targeted towards people with Ashkenazi Jewish descent. Probably because they are much more present in their datasets.
Either way it seems like a lose-lose for me because on one hand I am getting mediocre results, but on the other I am relinquishing my privacy.
Re: Ask HN: What did you find in your DNA using 23andme?
#17My father had Factor V Leiden[1], a mutation that increases blood clotting. He was hospitalized multiple times in his 30s, and died suddenly at age 50. After his first blood clot he was put on anti-coagulants and took them every day of his life.
There is a 50% chance to pass this mutation to your offspring, and I wanted to know whether I could be affected. I discovered that I did indeed inherit the same allele, and went to see a hematologist to discuss it. She advised that I not smoke and keep fit (unlike my father) and that I shouldn't worry about taking medication unless some evidence of blood clots appears. This was always a worry for me, not knowing whether I would suffer the same fate. When I sent my DNA to 23andme, I was 25 years old and wondering if I'd already lived half of my life. Getting the results and following up with a specialist gave me great relief and eliminated this worry pretty much entirely.
Re: Ask HN: What did you find in your DNA using 23andme?
#18Earlier quoted context omitted.
How did you find your ideal wake time?
https://you.23andme.com/reports/trait.wakeup_time/ (visit when logged in)
Mine is 8:32 AM which is roughly about accurate.
I wonder they did it via back connecting my phone's wake up time as the founder of 23andme and Google were/are connected ;)
Re: Ask HN: What did you find in your DNA using 23andme?
#19Doctor Rhonda Patrick's website allows you to upload your data to and have additional analysis done: https://www.foundmyfitness.com/genetics
Has anyone tried this? How were the results?
Re: Ask HN: What did you find in your DNA using 23andme?
#20My spouse did it and the results provided by 23andMe were next to useless. It told her interesting facts like that she likely has no dimples (she has them), and other meaningless crap. However, she downloaded the raw data and ran it through Promethease[0] and it did supply some useful info about potential drug interactions, which has been useful. She supplied a fake name to them, used a gift card to pay for it online…
You violate the terms of their service when you use a fake name. If you don't want to use your real information, pay $1000 for a full sequencing. Their rates are lower because they're able to subsidize consumers with selling aggregate information to drug companies for rapid drug prototyping and development. EDIT: I am astounded by the entitlement complex exhibited in the replies to this. You don't have to agree to th…
Their rates are far lower than whole genome sequencing because it is a "Genotyping chip" or SNP Array.
They don't sequence your genome, they look for about 600,000 common SNPs.
If you do get your whole genome sequenced (as opposed to the outdated exome sequencing), you will get a lot of data but it will be difficult to utilize. 23andme has survey data + lots of customers, and can do this type of statistical genome-wide association studies (GWAS). With your whole genome, you will have much higher resolution data about yourself, but limited ability to leverage the additional data.