Long-Awaited Study Results on Vitamin D and Fish Oil Supplements
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Re: Long-Awaited Study Results on Vitamin D and Fish Oil Supplements
#2Except as fish oil supplements relate to heart attacks (headline is misleading IMHO):
> While the overall results were disappointing, there appeared to be a beneficial effect when it came to one aspect of heart disease and fish oil: heart attacks.
> Taking fish oil lowered the risk of heart attack by about 28 percent, which is a "statistically significant" finding, says Dr. JoAnn Manson, who is chief of the division of preventive medicine at the Brigham and Women's Hospital in Boston. She led the research.
> Those who appeared to benefit the most were people who didn't ordinarily eat much fish in their day-to-day diet, as well as African Americans, Manson says.
> African-Americans in the study experienced a 77 percent lower risk of heart attack when compared to placebo, which is a "dramatic reduction," Manson says. Further research is needed to confirm these findings, she adds, but, "in the meantime it would be reasonable for African Americans to talk with their health care providers about whether they may be candidates for taking fish oil supplements."
Re: Long-Awaited Study Results on Vitamin D and Fish Oil Supplements
#3https://www.nejm.org/doi/full/10.1056/NEJMoa1809944
Abstract: 'It is unclear whether supplementation with vitamin D reduces the risk of cancer or cardiovascular disease, and data from randomized trials are limited. Methods
We conducted a nationwide, randomized, placebo-controlled trial, with a two-by-two factorial design, of vitamin D3 (cholecalciferol) at a dose of 2000 IU per day and marine n−3 (also called omega-3) fatty acids at a dose of 1 g per day for the prevention of cancer and cardiovascular disease among men 50 years of age or older and women 55 years of age or older in the United States. Primary end points were invasive cancer of any type and major cardiovascular events (a composite of myocardial infarction, stroke, or death from cardiovascular causes). Secondary end points included site-specific cancers, death from cancer, and additional cardiovascular events. This article reports the results of the comparison of vitamin D with placebo. Results
A total of 25,871 participants, including 5106 black participants, underwent randomization. Supplementation with vitamin D was not associated with a lower risk of either of the primary end points. During a median follow-up of 5.3 years, cancer was diagnosed in 1617 participants (793 in the vitamin D group and 824 in the placebo group; hazard ratio, 0.96; 95% confidence interval [CI], 0.88 to 1.06; P=0.47). A major cardiovascular event occurred in 805 participants (396 in the vitamin D group and 409 in the placebo group; hazard ratio, 0.97; 95% CI, 0.85 to 1.12; P=0.69). In the analyses of secondary end points, the hazard ratios were as follows: for death from cancer (341 deaths), 0.83 (95% CI, 0.67 to 1.02); for breast cancer, 1.02 (95% CI, 0.79 to 1.31); for prostate cancer, 0.88 (95% CI, 0.72 to 1.07); for colorectal cancer, 1.09 (95% CI, 0.73 to 1.62); for the expanded composite end point of major cardiovascular events plus coronary revascularization, 0.96 (95% CI, 0.86 to 1.08); for myocardial infarction, 0.96 (95% CI, 0.78 to 1.19); for stroke, 0.95 (95% CI, 0.76 to 1.20); and for death from cardiovascular causes, 1.11 (95% CI, 0.88 to 1.40). In the analysis of death from any cause (978 deaths), the hazard ratio was 0.99 (95% CI, 0.87 to 1.12). No excess risks of hypercalcemia or other adverse events were identified. Conclusions
Supplementation with vitamin D did not result in a lower incidence of invasive cancer or cardiovascular events than placebo. (Funded by the National Institutes of Health and others; VITAL ClinicalTrials.gov number, NCT01169259.)'
Re: Long-Awaited Study Results on Vitamin D and Fish Oil Supplements
#4Except as fish oil supplements relate to heart attacks (headline is misleading IMHO): > While the overall results were disappointing, there appeared to be a beneficial effect when it came to one aspect of heart disease and fish oil: heart attacks. > Taking fish oil lowered the risk of heart attack by about 28 percent, which is a "statistically significant" finding, says Dr. JoAnn Manson, who is chief of the division…
Likewise a Vitamin-D deficiency can make your tongue swell a bit. Is it a long term health issue? No. But, is it annoying af to bite your tongue and mess words up, yes it is.
Edit: LOL downvotes for a straight up medical fact :D
Re: Long-Awaited Study Results on Vitamin D and Fish Oil Supplements
#5Been taking 10k IU of D3 for a few months now, managed to get my measurement from the teens or 20s into the 90s of whatever unit that's in. I believe 100 is the max of the healthy range. Can't tell the difference, but allegedly you're going to feel "worse" if you're low on this stuff.
It would be amusing to find out that it actually makes no difference at all and it's all placebo.
Re: Long-Awaited Study Results on Vitamin D and Fish Oil Supplements
#6Been taking 10k IU of D3 for a few months now, managed to get my measurement from the teens or 20s into the 90s of whatever unit that's in. I believe 100 is the max of the healthy range. Can't tell the difference, but allegedly you're going to feel "worse" if you're low on this stuff. It would be amusing to find out that it actually makes no difference at all and it's all placebo.
I find it helps a little in the winter when it’s dark and rainy all the time. It’s cheap so I don’t see a downside if it is acting as a placebo.
Re: Long-Awaited Study Results on Vitamin D and Fish Oil Supplements
#7It always seemed unlikely to me that any single substance that can be ingested as a supplement would have any significant effect on general malignancies. There are probably thousands of paths by which these can occur, one magic pill that would address them all is improbable to say the least.
Re: Long-Awaited Study Results on Vitamin D and Fish Oil Supplements
#8In my opinion, the best benefit of fish oil and Omega threes and vitamin D are in combating depression. This article did not touch on that. There is pretty good evidence that fish oil is one of the best supplements for combating depression because it is used directly in construction of neurotransmitter pathways.
I highly recommend reading Dr Mark Hyman's book the Ultramind Solution. It's loaded with great info regarding nutrition and how it affects your brain. It is truly life changing information. He also had a podcast called Broken Brain that is worth checking out.
Julia Ross' the Mood Cure is good too, the not as detailed (tho that can be good if you are feeling overwhelmed).
Re: Long-Awaited Study Results on Vitamin D and Fish Oil Supplements
#9Why do we keep looking for some magic pill and ignore diet and exercise, especially when we talk about cancer and cardiovascular disease? Expecting a pill to counteract a sedentary lifestyle and a diet high in sugar and carbs is lunacy.
Re: Long-Awaited Study Results on Vitamin D and Fish Oil Supplements
#10https://www.nejm.org/doi/full/10.1056/NEJMoa1809944 Abstract: 'It is unclear whether supplementation with vitamin D reduces the risk of cancer or cardiovascular disease, and data from randomized trials are limited. Methods We conducted a nationwide, randomized, placebo-controlled trial, with a two-by-two factorial design, of vitamin D3 (cholecalciferol) at a dose of 2000 IU per day and marine n−3 (also called omega-3…
What they tried: 2000 IU (1 tablet) of Vit D3 and 1g of Omega 3 per day.
Who they tried it on: older adults in USA.
What they found: no difference in risk of cancer, heart attack, stroke, or death.