I really dislike TV/Anime that never ends, seems to be the modus operandi for pretty much every mainstream show despite how bad the quality gets after 2-3 seasons.
Simpsons is a great showcase of the homogenization that every sitcom will go through given enough time. It starts out as a comedy with some wholesome family moments to bring it together but eventually every character is distilled to their most basic formula Homer -> Idiot who causes events to happen Bart -> Same as above Marge -> Straight man / Voice of reason or Satire of moralistic conservative adults depending on the situation Lisa -> same as marge but liberal piñata
Old episodes had genuine moments where you saw them become closer as family, now every episode is a hodgepodge of nonstop comedy.
Family Guy also went through this, especially after they got revived. The early episodes focused on the trials of the family with some goofy humor peppered throughout (Peter getting fired, Louis dealing with being a bored housewife) but now its just nonstop comedy.
Once you get syndicated it's not about making good episodes just churning out 26 more a year and cashing in that paycheck.
Even Steven Universe which has a very straightforward story with an end planned feels bloated with a bunch of filler episodes and lazy character development.