Earlier quoted context omitted.
You can send email from an EC2 instance but good luck getting anyone to accept it. A lot of email providers block EC2 wholesale, or if they do accept it you are going to have to have a long standing reputation.
What do you mean by blocking "wholesale"? I started hosting an email server in EC2 and the worst I've had is my emails going to a spam folder if that person hasn't received an email from my address yet (and never after they've marked me as not being spam). That happened surprisingly rarely and didn't feel like much worse than I would get by just sending people email from gmail with an address they don't know. I don't…
GMail is more reasonable with perhaps being spam filtered but never blocked outright. I have also been blocked by government labs and academic institutions. I also have complied with RDNS, DKIM, SPF and got a top score on mx toolbox. Now that I have been up for a while I have had less issues besides with the ones that block cloud provider spaces.